PENTA 16 (BREATHER)

Economic evaluation of weekends-off antiretroviral therapy for young people in 11 countries

26 Dec, 2018

Authors: Tierrablanca LE, Ochalek J, Ford D, et al; for BREATHER (PENTA 16) Trial Group Published in: Medicine (Baltimore). 2018;97(5):e9698 Objectives To analyze the cost effectiveness of short-cycle therapy (SCT), where patients take…
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Weekends-off efavirenz -based antiretroviral therapy in HIV infected children, adolescents and young adults (BREATHER): extended follow-up results of a randomised, open-label, non-inferiority trial

26 Dec, 2018

Authors: Turkova A, Moore CL, Butler K, et al. for BREATHER (PENTA 16) Trial Group. Published in: PLos One. 2018;13(4):e0196239. Background Weekends off antiretroviral therapy (ART) may help engage HIV-1-infected young people facing…
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Qualitative study of the BREATHER trial (Short Cycle antiretroviral therapy): is it acceptable to young people living with HIV?

21 Dec, 2017

Authors: Bernays S, Paparini S, Seeley J, Namukwaya Kihika S, Gibb D, Rhodes T. Published in: BMJ Open. 2017;7(2):e012934 Objectives A qualitative study of the BREATHER (PENTA 16) randomised clinical trial, which…
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“How Do We Start? And How Will They React?” Disclosing to Young People with Perinatally Acquired HIV in Uganda

13 Dec, 2017

Despite great advances in pediatric HIV care, rates and the extent of full disclosure of HIV status to infected children remain low especially in resource-constrained setting. The World Health Organisation…
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“Not Taking it Will Just be Like a Sin”: Young People Living with HIV and the Stigmatization of Less-Than-Perfect Adherence to Antiretroviral Therapy

01 Jul, 2017

Global health priorities are being set to address questions on adherence to HIV antiretroviral therapy in adolescence. Few studies have explored young people's perspectives on the complex host of social…
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BREATHER (PENTA 16) short-cycle therapy (SCT) (5 days on/2 days off) in young people with chronic human immunodeficiency virus infection: an open, randomised, parallel-group Phase II/III trial

01 Jun, 2016

Author: Butler K, Inshaw J, Ford D, et al. Published in:  Health Technol Assess. 2016;20(49):1-108. Background For human immunodeficiency virus (HIV)-infected adolescents facing lifelong antiretroviral therapy (ART), short-cycle therapy (SCT) with long-acting agents…
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Weekends-off efavirenz-based antiretroviral therapy in HIV-infected children, adolescents, and young adults (BREATHER): a randomised, open-label, non-inferiority, phase 2/3 trial

01 Jun, 2016

Author: The BREATHER (PENTA 16) Trial Group Published in: Lancet HIV. 2016;3(9):e421-430 Background For HIV-1-infected young people facing lifelong antiretroviral therapy (ART), short cycle therapy with long-acting drugs offers potential for drug-free weekends,…
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When information does not suffice: young people living with HIV and communication about ART adherence in the clinic

01 Jan, 2016

Authors: S. Bernays, S. Paparini, D. Gibb & J. Seeley Published in: Vulnerable Child Youth Stud. 2016;11(1):60-68 Abstract Despite mounting evidence recommending disclosure of human immunodeficiency virus (HIV) status to young…
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I was like, oh my God, what happens if it doesn’t work’? Young people living with HIV, clinical trial participation and the truth economy

11 Sep, 2015

Authors: Bernays S, Seeley J, Paparini S, Rhodes T Published: BSA Medical Sociology Conference, York, 9-11 September 2015 (Paper ID No: W0012148)
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I am scared of getting caught up in my lie’: challenges to self-reported adherence for young people living with HIV

18 Jul, 2015

Authors:  Bernays S, Seeley J, Paparini S, Rhodes T and the ARROW and BREATHER trial teams. Published in: accepted for presentation at AIDS Impact, Amsterdam 28-31 July, 2015 (abstract 3435)
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Young people, clinical trials and ‘the HIV experience’: What can similarities across time and place tell us about growing up with HIV?

18 Jul, 2015

Authors:  Paparini S on behalf of Bernays S, Seeley S,  Rhodes T,  Namukwaya Kihika S,Kawuma-Kigawa R, Nakyambadde H, Kabajaasi O and the BREATHER Trial Team. Published in: 3rd International ASSHH Conference, Stellenbosch,…
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“But it’s my story”: exploring the experience and effect of telling children how they have acquired HIV

18 Jul, 2015

Authors:  Seeley J on behalf of the Bernays S, Paparini S, Namukwaya Kihika S,  Rhodes T and the BREATHER Trial Team. Published in: 3rd International ASSHH Conference, Stellenbosch, South Africa, 6-9…
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ART With Weekends Off Is Noninferior to Continuous ART in Young People on EFV+2NRTI

23 Feb, 2015

Authors: Karina M. Butler on behalf of the BREATHER trial team Published in: CROI 2015, Seattle, USA, Feb 23 -26 2015. Abstract For HIV-1 infected young people (YP) facing lifelong ART,…
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HIV-1 Drug Resistance and Second-line Treatment in Children Randomized to Switch at Low versus Higher RNA Thresholds

01 Jan, 2015

Authors: Harrison L, Melvin A, Fiscus S, et al; PENPACT-1 (PENTA 9PACTG 390) Study Team. Published in: J Acquir Immune Defic Syndr. 2015;70(1):42-53 Background The PENPACT-1 trial compared virologic thresholds to determine when…
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