News

2

Sep, 2018

Time of ART initiation in perinatally HIV-infected children impacts on HIV-specific T cell functionality

 

Authors: Rinaldi S, Cotugno N, Pallikkuth S, Pahwa R, Palma P, Pahwa S Published in: J Immunol. 2018; 200(1):166 Abstract Early initiation of antiretroviral therapy (ART) in vertically HIV-infected children provides an opportunity to limit the size of HIV reservoir. However, how the time of ART initiation impacts host HIV-specific immune responses is still poorly understood. In this study, we analyzed HIV-specific CD4 and CD8 T cell functionality in vertically HIV-infected children (age range 2.3–17.5yrs) enrolled at Bambino Gesù Children Hospital under suppressive ART and durable viral control (plasma HIV-RNA<50cp/mL). […]

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2

Sep, 2018

Time to viral rebound after stopping art in children treated from infancy in cher

 

Authors: Violari A, Chan M, Otwombe KN, Panchia R, Jean-Philippe P, Gibb D, Cotton M, Babiker A Published: Oral presentation at 25th Conference on Retroviruses and Opportunistic Infections, March 4th – 7th, 2018 – Boston.  Abstract We investigated factors associated with time to viral rebound in children in CHER who started ART at age <12 weeks and received 40 (ART-40W) or 96 weeks (ART-96W) of primary therapy. HIV RNA viral load (VL) from stored samples was assessed 8 weeks after interruption and 12 weekly thereafter. Included were children with VL<400 […]

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2

Sep, 2018

Lasting immune impacts of age at start of ART in vertically HIV-infected adolescents

 

Authors: Cameron M, Rinaldi S, Richardson B, Cotugno N, Williams S, Pallikkuth S, de Armas LR, Cameron C, Pahwa R, Palma P, Pahwa S Published: 25th Conference on Retroviruses and Opportunistic Infections, March 4th – 7th, 2018 – Boston. P_868 Abstract The study explores the impact of early ART on host immune response looking at HIV-specific CD4 T cell functionality and host transcriptome analysis.

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2

Sep, 2018

Factors associated with HIV DNA levels in children starting antiretroviral therapy (ART) early in infancy

 

Authors: Chan M, Tagarro A, Zangari P, Ferns B, Foster C, De Rossi A, Nastouli E, Ángeles Muñoz-Fernández M, Gibb D, Rossi P, Giaquinto C, Babiker A , Palma P, Rojo Conejo P Published: 25th Conference on Retroviruses and Opportunistic Infections, March 4th – 7th, 2018 – Boston. P_ 866 Abstract The study focused on the determinants of low viral reservoir in a large cohort of European early treated HIV-1 infected children. Timing of cArt initiation and timing spent on effective ART are main factors associated with low HIV-DNA

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