Antibiotics needed to treat multidrug-resistant infections in neonates

24 Nov, 2022

Authors: CM Williams PCM, Qazi SA, Agarwal R, Velaphi S, Bielicki JA, Nambiar S, Giaquinto C, Bradley J, Noel GJ, Ellis S, O’Brien S, Balasegaram M & Sharland M Published in:…
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Optimised versus standard dosing of vancomycin in infants with Gram-positive sepsis (NeoVanc): a multicentre, randomised, open-label, phase 2b, non-inferiority trial

03 Dec, 2021

Authors: Hill L.F, Clements M.N, Turner M.A, Donà D, Lutsar I, Jacqz-Aigrain E, Heath P.T, Roilides E, Rawcliffe L, Alonso-Diaz C, Baraldi E, Dotta A, Ilmoja M, Mahaveer A, Metsvaht…
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Global estimates of the relative pediatric consumption and cost of oral amoxicillin and amoxicillin plus clavulanic acid

20 Jul, 2021

Authors: G. A. Levine, M. Sharland, S. Ellis, Y. Ferrisse, C. Loze, Y. Hsia, G. Fink, J. Bielicki; for the PediCAP project Published in: ECCMID 2021   Abstract Background: Amoxicillin…
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Harmonising regulatory approval for antibiotics in children

21 Jan, 2021

Authors: Phoebe C M Williams, John Bradley, Emmanuel Roilides, Linus Olson, Sheldon Kaplan, Irja Lutsar, Carlo Giaquinto, Daniel K Benjamin, Mike Sharland Published in: The Lancet Introduction: Antimicrobial resistance represents a substantial…
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Global sales of oral antibiotics formulated for children

02 Jul, 2020

Authors: Li G, Jackson C, Bielicki J, Ellis S, Hsiac Y, Sharland M Published in: Bulletin of the World Health Organization, July 2020 Objective To investigate international consumption patterns of…
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A comparison of five paediatric dosing guidelines for antibiotics

28 Apr, 2020

Authors: Mathur S, Jackson C, Urus H, Ziarko I, Goodbun M, Hsia Y, Ellis S, Sharland M. Published in: Bulletin of the World Health Organization, April 2020 Objective To compare…
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Interim pharmacokinetic analysis of a multi-centre randomised open label phase IIb study in neonates to validate the meta-analysis population pharmacokinetic model used to simulate an optimised dosing regimen in neonates and infants aged < 90 days: the NeoVanc trial

26 Apr, 2020

Authors: L. Hill, E. Jacqz-Aigrain, V. Elie, W. Zhao, M. Clements, M. Turner, I. Lutsar, P. Heath, E. Roilides, S. Walker, M. Sharland Published in: 30th European Congress on Clinical…
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An optimised dosing regimen vs. a standard dosing regimen of vancomycin for the treatment of late onset sepsis due to Gram-positive microorganisms in infants less than 90 days: the NeoVanc trial

26 Apr, 2020

Authors: L. Hill, M. Clements, M. Turner, I. Lutsar, E. Jacqz-Aigrain, P. Heath, E. Roilides, S. Walker, M. Sharland Published in: 30th European Congress on Clinical Microbiology and Infectious Diseases…
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Application of WISCA (Weighted Incidence Syndromic Combination Antibiogram) to guide empiric therapy in oncological paediatric patients with febrile neutropenia

26 Apr, 2020

Authors: E. Barbieri, D. Bottigliengo, P. Costenaro, A. Marzollo, M. Petris, M. Pierobon, G. Biddeci, C. Giaquinto, A. Biffi, D. Donà Published in: 30th European Congress on Clinical Microbiology and…
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Antibiotic treatment for paediatric outpatients with community-acquired pneumonia: findings from 10 years of prescribing habits in Italy

26 Apr, 2020

Authors: P. Costenaro, A. Cantarutti, E. Barbieri, A. Scamarcia, A. Oletto, P. Sacerdoti, R. Lundin, L. Cantarutti, C. Giaquinto, D. Dona’ Published in: 30th European Congress on Clinical Microbiology and…
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Implementation and impact of pediatric antimicrobial stewardship programs: a systematic scoping review

10 Jan, 2020

Authors: Donà D, Barbieri E, Daverio M, Lundin R, Giaquinto C, Zaoutis T, Sharland M Published in: Antimicrob Resist Infect Control.2020;9:3 Background Antibiotics are the most common medicines prescribed to…
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Standardising neonatal and pediatric anitibiotic clinical trial design and conduct: the PENTA-ID network review

30 Dec, 2019

Authors: Folgori L, Lutsar I, Standing JF, et al. Published in: BMJ Open. 2019; 9:e032592 Abstract: Antimicrobial development for children remains challenging due to multiple barriers to conducting randomised clinical…
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Towards understanding global patterns of antimicrobial use and resistance in neonatal sepsis: insights from the NeoAMR network

16 Oct, 2019

Authors: Li G, Bielicki JA, Ahmed ASMNU, et al. Published in: Arch Dis Child.2091;0:1-6 Objective To gain an understanding of the variation in available resources and clinical practices between neonatal units (NNUs) in the low-income and…
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Differential susceptibility of Staphylococcus epidermidis biofilms to vancomycin, daptomycin and linezolid between clinical Isolates from neonates and adults

15 Oct, 2019

Authors:Simitsopoulou M, Kadiltzoglou P, Kyrpitzi D, Roilides E. Published in: Int J Biol Med Res.2019;10(1):6591-6596 Abstract This study aimed to compare the effects of vancomycin, linezolid and daptomycin against planktonic…
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Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants

14 Oct, 2019

Authors: Jacqz-Aigrain E, Leroux S, Thomson AH, et al. Published in: J Antimicrob Ther 2019; 74(8):2128-2138
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Use of the WHO Access, Watch, and Reserve classification to define patterns of hospital antibiotic use (AWaRe): an analysis of paediatric survey data from 56 countries.

18 Jun, 2019

Authors: Hsia Y, Lee BR, Versporten A, et al; GARPEC and Global-PPS networks. Published in: Lancet Glob Health. 2019;7(7):e861-e871 Background Improving the quality of hospital antibiotic use is a major goal of WHO’s global…
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Hard to study, hard to treat: putting children at the centre of antibiotic research and development

05 Jun, 2019

Authors: Balasegaram M, Pécoul B, Gray G, Sharland M, Swaminathan S. Published in: Lancet Infect Dis. 2019;19(6):573-574 Abstract Newborn babies, infants, and children are substantially affected by antimicrobial resistance. Globally,…
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