Antimicrobials

R&D for children’s antibiotics – a wake-up call

28 May, 2019

Authors: O’Brien S, Sharland M, Zaoutis T Published in: AMR CONTROL 2019-2020; online edition Abstract It is time to prioritize children’s needs in the context of antimicrobial resistance (AMR). Children,…
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The use of polymyxins to treat carbapenem resistant infections in neonates and children

26 Apr, 2019

Authors: Thomas R, Velaphi S, Ellis S, et al. Published in: Expert Opin Pharmacother. 2019;20(4):415-422.  Introduction The incidence of healthcare-associated multidrug resistant bacterial infections, particularly due to carbapenem resistant organisms, has been on the rise…
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Effects of an antimicrobial stewardship intervention on perioperative antibiotic prophylaxis in pediatrics

26 Apr, 2019

Authors: Donà D, Luise D, La Pergola E, et al. Published in: Antimicrob Resist Infect Control. 2019;8:13.  Purpose This study aims to determine the effectiveness of anAntimicrobial Stewardship Program based on a…
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High rates of prescribing antimicrobials for prophylaxis in children and neonates: results from the antibiotic resistance and prescribing in European children point prevalence survey

26 Dec, 2018

Authors: Hufnagel M, Versporten A, Bielicki J, et al.; for ARPEC Project Group. Published in: J Pediatric Infect Dis Soc. 2018. doi: 10.1093/jpids/piy019. Background This study was conducted to assess the variation…
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The impact of clinical pathways on antibiotic prescribing for acute otitis media and pharyngitis in the emergency department

26 Dec, 2018

Authors: Dona D, Baraldi M, Brigadoi G, et al. Published in: Pediatr Infect Dis J. 2018;37(9):901-907. Background Although Italian pediatric antimicrobial prescription rates are among the highest in Europe, little action has…
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Plasma and CSF pharmacokinetics of meropenem in neonates and young infants : results from the NeoMero studies

26 Apr, 2018

Authors: Germovesk E, Lutsar I, Kipepr K, et al.; for NeoMero Consortium Published in: J Antimicrob Chemother. 2018;73(7):1908-1916 Background Sepsis and bacterial meningitis are major causes of mortality and morbidity in…
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Surveillance for control of antimicrobial resistance

26 Apr, 2018

Authors: Tacconelli E, Sifakis F, Harbarth S, et al; for EPI-Net COMBACTE-MAGNET Group Published in: Lancet Infect Dis. 2018;18(3):e99-e106. Abstract Antimicrobial resistance poses a growing threat to public health and the provision of…
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Effects of clinical pathway implementation on antibiotic prescription for pediatric community-acquired pneumonia

26 Apr, 2018

Authors: Donà D, Zingarella S, Gastaldi A, et al. Published in: PLoS One. 2018;13(2):e0193581.  Background Italian pediatric antimicrobial prescription rates are among the highest in Europe. As a first step in…
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Pharmacodynamics of vancomycin for CoNS infection: experimental basis for optimal use of vancomycin in neonates

15 Dec, 2016

Authors: Ramos-Martin R , Johnson A, Livermore J, et al. Published in: J Antimicrob Ther 2016;71(4):992-1002 Objectives CoNS are the most common cause of neonatal late-onset sepsis. Information on the…
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