Early ART initiation during infancy preserves natural killer cells in young European adolescents living with HIV (CARMA cohort)
09 Jul, 2021
Authors: M Doria, S Zicari, N Cotugno, S Domínguez-Rodríguez, A Ruggiero, GR Pascucci, A Tagarro, PR Conejo, E Nastouli, K Gärtner, M Cameron, B Richardson, Ce Foster, SL Williams, S Rinaldi, AD Rossi, C Giaquinto, P Rossi, S Pahwa, P Palma, for the EPIICAL consortium Published in: Journal of the…
Read MoreThe CARMA study: early infant antiretroviral therapy—Timing impacts on total HIV-1 DNA quantitation 12 years later
21 Jul, 2020
Authors: Foster C, Domínguez-Rodríguez S, Tagarro A, et al. For the Early Treated Perinatally HIV Infected Individuals: Improving Children’s Actual Life (EPIICAL) Consortium Published in: J Pediatr Infect Dis Soc.…
Read MoreThe size of HIV reservoir is associated with telomere shortening and immunosenescence in early ART-treated HIV-infected children
13 Jul, 2020
Authors: De Rossi A, Dalzini A, Ballin G, Dominguez-Rodriuguez S, Rojo P, Foster C, Palma P, Sessa L, Nastouli E, Pahwa S, Rossi P, Giaquinto C, EPIICAL Consortium Published in:…
Read MoreAging B-cells (ABC) and anti-Env humoral responses are associated with T-bet expression in B-cells of perinatally HIV infected children (PHIV) treated within 24 months (m) of life (the CARMA cohort)
13 Jul, 2020
Authors: Ruggiero A, Cotugno N, Domínguez-Rodríguez S, Zicari S, Rinaldi S, Zangari P, Tagarro A, Foster C, De Rossi A, Nastouli E, Luzuriaga K, Giaquinto C, Rossi P, Pawha S,…
Read MoreA machine learning approach for predicting probability of death or disease progression in an early-treated pediatric African cohort
12 Jul, 2020
Authors: Domínguez-Rodríguez S, Tagarro A, Serna Pascual M, Otwombe K, Violari A, Fernández S, Nhampossa T, Lain M, Vaz P , Behuhuma NO, Danaviah S, Dobbels E, Barnabas S, Cotugno…
Read MoreThe HIV-1 antibody response: a footprint of the viral reservoir in children vertically infected with HIV
31 May, 2020
Authors: Palma P, McManus M, Cotugno N, Rocca S, Rossi P, Luzuriaga K Published in: Lancet HIV. 2020;7(5):e359-e365 Abstract Several assays have been developed to measure and characterise the replication-competent…
Read MoreDifferences in inducibility of the latent HIV reservoir in perinatal and adult infection
12 May, 2020
Authors: Dhummakupt A, Rubens JH, Andeson T, et al. Published in: JCI Insight. 2020;5(4) Abstract The HIV latent reservoir in resting memory CD4+ T cells precludes cure. Therapeutics to reactivate…
Read MoreDifferences in inducibility of the latent HIV reservoir in perinatal and adult infection
12 Apr, 2020
Authors: Dhummakupt A, Reubens JH, Anderson T, et al. Published: Poster presented at 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston. Abstract The HIV latent…
Read MoreTime to viral suppression in perinatally HIV-infected infants depends on the viral load and CD4 T-cell percentage at the start of treatment
27 Mar, 2020
Authors: Schröter J, Anelone A, Yates A, de Boer RJ; on behalf of the EPIICAL Consortium Published in: J Acquir Immune Defic Syndr. 2020;83(5):522-529 Background Interventions aiming for an…
Read MoreMothers’ adherence helps in identifying more infants in need of extended prophylaxis
16 Mar, 2020
Authors: Dominguez-Rodriguez S, Rojo P, Lain MG, Barnabas S, Lopez-Varela E, Otwombe K, Danaviah S, Nastouli E, Serna-Pasqual M, Gianuzzi V, Giaquointo C, Kuhn L, Tagarro A on behalf of…
Read MoreNK Cells are preserved by early ART in HIV-infected children with lower reservoir
13 Mar, 2020
Authors: Zicari S, Doria M, Domínguez-Rodríguez S, Cotugno N, Tagarro A, Rojo P, Nastouli E, Gartner K, Klein N, Foster C, Pahwa S, De Rossi A, Giaquinto C, Rossi P, …
Read MorePoor outcome in early treated HIV perinatally infected infants in Africa
13 Mar, 2020
Authors: Tagarro A, Domínguez-Rodríguez S, Violari A, Cotton M, Mhampossa T, Klein N, Ramsagar N, Van Rensburg AJ, Behuhuma O, Vaz P, Oletto A, Palma P, Rossi P, Rojo P,…
Read MoreAssessment of HIV-1 DNA by single-genome sequencing in children on suppressive ART
13 Mar, 2020
Authors: Gärtner K, Gkouleli T, Byott M, Heaney J, Spyer MJ, DeRossi A, Persaud D, Palma P, Giaquinto C, Rojo P, Foster C, Marcelin AG, Rossi P, Nastouli E, for…
Read MoreCell-associated HIV-1 DNA/RNA in children: performance of real-time and digital PCR
13 Mar, 2020
Authors: Gärtner K, Gkouleli T, Heaney J, Grant P, Dominguez-Rodriguez S, Busby E, O’Sullivan D, Spyer MJ, Foster C, Rojo P, Persaud D, DeRossi A, Huggett J, Nastouli E, for…
Read MoreMarkers of HIV reservoir size in infected children on long-term viral control
13 Mar, 2020
Authors: Rinaldi S, Pallikkuth S, de Armas L, Pahwa R, Dominguez S, Cotugno N, Rojo Conejo P, Nastouli E, Gartner K, Klein N, Foster C, De Rossi A, Carlo Giaquinto…
Read MoreViral response in HIV infected infants starting ART at 1 month in Southern Mozambique
13 Mar, 2020
Authors: Lain MG, Vaz P, Ismael N, Cantarutti A, Porcu G, Palma P, Cotugno N, Bila D, Rinaldi S, Pallikkuth S, Pahwa R, Taibo E, Esmeralda Karajeanes E, Giaquinto C,…
Read Moreushr: Understanding suppression of HIV in R
28 Feb, 2020
Authors: Morris SE, Dziobek-Garrett L, Yates AJ and the EPIICAL consortium Published in: BMC Bioinformatics 2020;21(1):52 Background HIV/AIDS is responsible for the deaths of one million people every year. Although…
Read MoreEarly ART-treated perinatally HIV-infected seronegative children demonstrate distinct long-term persistence of HIV-specific T and B cell memory
19 Feb, 2020
Authors: Cotugno N, Morrocchi E, Rinaldi S, et al; EPIICAL Consortium. Published in: AIDS. 2020 Feb 3. Objective To investigate long-term persistence of HIV-specific lymphocyte immunity in perinatally HIV-infected children treated within…
Read More