General Penta Pubblications


Nov, 2017

Treatment of Community-Acquired Pneumonia: Are All Countries Treating Children in the Same Way? A Literature Review


Authors: Donà D, Luise D, Da Dalt L, Giaquinto C.

Published in: Int J Pediatr; 2017: 4239268. Epub 2017

AbstractBackground. Pneumonia represents an important threat to children’s health in both developed and developing countries. In the last 10 years, many national and international guidelines on the treatment of pediatric CAP have been published, in order to optimize the prescription of antibiotics and limit their cost and side effects. However, the practical implementation of these guidelines is still limited. Main Text. We analyzed the current recommendations for the therapy of pediatric community-acquired pneumonia (CAP) that all converge on the identification of aminopenicillins and beta-lactams as the optimal treatment for CAP. We also conducted a review of the current literature on antibiotic regimens used for pediatric CAP to identify the current state of guidelines implementation in different settings. We selected 37 studies published from 2010 to 2016, including both retrospective and prospective studies, mainly cross-sectional and hospital based. The results show a global heterogeneity in the antibiotics prescription for pediatric CAP, with application of guidelines varying from 0% to more than 91% and with important differences even within the same country. Conclusions. Our review has demonstrated that the implementation of the guidelines is still limited but also that achieving the optimal prescription is possible and can be done in both developed and developing countries.



Apr, 2012

Phylodynamic and Phylogeographic Patterns of the HIV-1 Subtype F1 Parenteral Epidemic in Romania.


Authors: Mbisa JL, Hue S, Buckton AJ, Myers RE, Duiculescu D, Ene L, Oprea C, Tardei G, Rugina S, Mardarescu M, Floch C, Notheis G, Zoehrer B, Cane PA, Pillay D.

Published in: AIDS Res Hum Retroviruses 2012 Jan 18.



Apr, 2010

Discordance between CD4 cell count and CD4 cell percentage: implications for when to start antiretroviral therapy in HIV-1 infected children. concise Communication.


Authors: HIV Paediatric Prognostic Markers Collaborative Study

Published in: AIDS 2010, 24, 1213–1217



Apr, 2009

PENTA 2009 Guidelines for the use of Antiretroviral therapy in paediatric HIV-1 infection


Authors: Welch S, Sharland M, Lyall EG, et al.

Published in: HIV Med. 2009 Nov;10(10):591-613.



Feb, 2009

Effect of early antiretroviral therapy on the risk of AIDS/death in HIV-infected infants.


Authors: Goetghebuer T, Haelterman E, Le Chenadec J, Dollfus C, Gibb D, Judd A, Green H, Galli L, Ramos JT, Giaquinto C, Warszawski J, Levy J; for the European Infant Collaboration group.

Published in:  AIDS 2009 Feb



Apr, 2008

A comparison of the rate of clinical disease progression in HIV-infected children and adults allowing for current CD4 cell count.


Authors: Dunn DT, Woodburn P, Duong T, Phillips AN, Gibb D, Porter K on behalf of HIV Paediatric Prognostic Markers Collaborative Study (HPPMCS) and the CASCADE Collaboration.

Published in: J Infect Dis 2008, 197:398-404



Feb, 2008

Marginal zone memory B-cell populations are irreversibly depleted in paediatric HIV infection.


Authors: Jacobsen MC, Thiebaut R, Fisher C, Sefe D, Clapson M, Klein NJ, Baxendale HE.

Published in: 5th Conference on Retroviruses and Opportunistic Infections, Boston, 2- 8 February 2008, Poster A-152 /453



Jan, 2008

Markers for predicting mortality in untreated HIV-infected children in resource-limited settings: a meta-analysis


Authors: Cross Continents Collaboration for Kids (3Cs4kids) Analysis and Writing Committee

Published in: AIDS. 2008 Jan 2;22(1):97-105.



Dec, 2007

Early versus deferred highly active antiretroviral therapy in HIV infected infants: a European Collaborative Cohort Study.


Authors: Goetghebuer T for the European Infant Collaborative Study.

Published in: 4th Dominique Dormont International Conference, 13-15 December, 2007


Apr, 2007

Increasing Antiretroviral Drug Access for Children With HIV Infection.


Published in: American Academy of Pediatrics, 2007; 119: 838-845