EPIICAL

The HIV-1 antibody response: a footprint of the viral reservoir in children vertically infected with HIV

31 May, 2020

Authors: Palma P, McManus M, Cotugno N, Rocca S, Rossi P, Luzuriaga K Published in: Lancet HIV. 2020;7(5):e359-e365 Abstract Several assays have been developed to measure and characterise the replication-competent…
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Differences in inducibility of the latent HIV reservoir in perinatal and adult infection

12 May, 2020

Authors: Dhummakupt A, Rubens JH, Andeson T, et al. Published in: JCI Insight. 2020;5(4) Abstract The HIV latent reservoir in resting memory CD4+ T cells precludes cure. Therapeutics to reactivate…
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Characterization of drug resistance and the defective HIV reservoir in virally suppressed vertically infected children in Mali

01 May, 2020

Authors: Brice J, Sylla M, Desire N, Sayon S, Telly F, Bocar-Fofana D, Murphy R, Peytavin G, Diallo S, Nastouli E, Calvez V, Marcelin AG, Maiga AI, Lambert-Niclot S Published…
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Differences in inducibility of the latent HIV reservoir in perinatal and adult infection

12 Apr, 2020

Authors: Dhummakupt A, Reubens JH, Anderson T, et al. Published: Poster presented at 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston. Abstract The HIV latent…
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Time to viral suppression in perinatally HIV-infected infants depends on the viral load and CD4 T-cell percentage at the start of treatment

27 Mar, 2020

Authors: Schröter J, Anelone A,  Yates A, de Boer RJ;  on behalf of the EPIICAL Consortium Published in: J Acquir Immune Defic Syndr. 2020;83(5):522-529   Background Interventions aiming for an…
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Mothers’ adherence helps in identifying more infants in need of extended prophylaxis

16 Mar, 2020

Authors: Dominguez-Rodriguez S, Rojo P, Lain MG,  Barnabas S, Lopez-Varela E, Otwombe K, Danaviah S, Nastouli E, Serna-Pasqual M, Gianuzzi V, Giaquointo C, Kuhn L, Tagarro A on behalf of…
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NK Cells are preserved by early ART in HIV-infected children with lower reservoir

13 Mar, 2020

Authors: Zicari S, Doria M, Domínguez-Rodríguez S, Cotugno N, Tagarro A, Rojo P, Nastouli E, Gartner K, Klein N, Foster C, Pahwa S, De Rossi A, Giaquinto C, Rossi P, …
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Poor outcome in early treated HIV perinatally infected infants in Africa

13 Mar, 2020

Authors: Tagarro A, Domínguez-Rodríguez S, Violari A, Cotton M, Mhampossa T, Klein N, Ramsagar N, Van Rensburg AJ, Behuhuma O, Vaz P,  Oletto A, Palma P, Rossi P, Rojo P,…
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Assessment of HIV-1 DNA by single-genome sequencing in children on suppressive ART

13 Mar, 2020

Authors: Gärtner K, Gkouleli T, Byott M, Heaney J, Spyer MJ, DeRossi A, Persaud D, Palma P, Giaquinto C, Rojo P, Foster C, Marcelin AG, Rossi P, Nastouli E, for…
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Cell-associated HIV-1 DNA/RNA in children: performance of real-time and digital PCR

13 Mar, 2020

Authors: Gärtner K, Gkouleli T, Heaney J, Grant P, Dominguez-Rodriguez S, Busby E, O’Sullivan D, Spyer MJ, Foster C, Rojo P, Persaud D, DeRossi A, Huggett J, Nastouli E, for…
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Markers of HIV reservoir size in infected children on long-term viral control

13 Mar, 2020

Authors: Rinaldi S, Pallikkuth S, de Armas L, Pahwa R, Dominguez S, Cotugno N, Rojo Conejo P, Nastouli E, Gartner K, Klein N, Foster C, De Rossi A, Carlo Giaquinto…
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Viral response in HIV infected infants starting ART at 1 month in Southern Mozambique

13 Mar, 2020

Authors: Lain MG, Vaz P, Ismael N,  Cantarutti A, Porcu G, Palma P, Cotugno N, Bila D, Rinaldi S,  Pallikkuth S, Pahwa R, Taibo E, Esmeralda Karajeanes E, Giaquinto C,…
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ushr: Understanding suppression of HIV in R

28 Feb, 2020

Authors: Morris SE, Dziobek-Garrett L, Yates AJ and the EPIICAL consortium Published in: BMC Bioinformatics 2020;21(1):52 Background HIV/AIDS is responsible for the deaths of one million people every year. Although…
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Early ART-treated perinatally HIV-infected seronegative children demonstrate distinct long-term persistence of HIV-specific T and B cell memory

19 Feb, 2020

Authors: Cotugno N, Morrocchi E, Rinaldi S, et al; EPIICAL Consortium. Published in: AIDS. 2020 Feb 3. Objective To investigate long-term persistence of HIV-specific lymphocyte immunity in perinatally HIV-infected children treated within…
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Impact of early antiretroviral therapy initiation on HIV-specific CD4 and CD8 T cell function in perinatally infected children

19 Feb, 2020

Authors: Rinaldi S, Pallikkuth S, Cameron M, et al. Published in: J Immunol. 2020 Feb 1;204:540-549 Abstract Early initiation of antiretroviral therapy (ART) in vertically HIV-infected children limits the size…
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PD-1+ CD4 T cells are associated with HIV reservoir size and impaired function of T follicular helper cells in children and young adults on long-term viral control

30 Dec, 2019

Authors: S. Rinaldi, V. Dinh, S. Pallikkuth, L. De Armas, R. Pahwa, N. Cotugno, E. Nastouli, C. Foster, P. Palma, S. Pahwa Published in: Poster presented at 9th International Workshop…
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Reduced time to suppression among neonates with HIV initiating antiretroviral therapy within 7 days of age

14 Nov, 2019

Authors: Domínguez-Rodríguez S, Tagarro A. Palma P, et al. Published in: JAIDS 2019;82(5):483-490 Abstract There are limited data on infants with HIV starting antiretroviral therapy (ART) in the neonatal period. We investigated the association…
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Time to HIV suppression in perinatally infected infants depends on the viral load and CD4 T-cell percentage at the start of treatment

12 Nov, 2019

Authors: Schröter J. Published in: Poster presented at 4th Workshop on Virus Dynamics, October 21st-23rd, 2019 -Paris, FR
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