EPIICAL

Impact of early antiretroviral therapy initiation on HIV-specific CD4 and CD8 T cell function in perinatally infected children

19 Feb, 2020

Authors: Rinaldi S, Pallikkuth S, Cameron M, et al. Published in: J Immunol. 2020 Feb 1;204:540-549 Abstract Early initiation of antiretroviral therapy (ART) in vertically HIV-infected children limits the size…
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PD-1+ CD4 T cells are associated with HIV reservoir size and impaired function of T follicular helper cells in children and young adults on long-term viral control

30 Dec, 2019

Authors: S. Rinaldi, V. Dinh, S. Pallikkuth, L. De Armas, R. Pahwa, N. Cotugno, E. Nastouli, C. Foster, P. Palma, S. Pahwa Published in: Poster presented at 9th International Workshop…
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Reduced time to suppression among neonates with HIV initiating antiretroviral therapy within 7 days of age

14 Nov, 2019

Authors: Domínguez-Rodríguez S, Tagarro A. Palma P, et al. Published in: JAIDS 2019;82(5):483-490 Abstract There are limited data on infants with HIV starting antiretroviral therapy (ART) in the neonatal period. We investigated the association…
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Time to HIV suppression in perinatally infected infants depends on the viral load and CD4 T-cell percentage at the start of treatment

12 Nov, 2019

Authors: Schröter J. Published in: Poster presented at 4th Workshop on Virus Dynamics, October 21st-23rd, 2019 -Paris, FR
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Detection of very low levels of cell-associated HIV-1 RNA in well suppressed adolescents (CARMA study)

12 Oct, 2019

Authors: Gärtner K, Gkouleli T, Heaney J, et al; on behalf of the EPIICAL consortium Published: Poster presented at HIV Cure and Reservoir Symposium, September, 16th-20th, 2019 -Ghent, BE
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The CARMA Study: Children on early suppressive ART Total HIV-1 DNA quantitation 12 years post ART initiation

02 Sep, 2019

Authors: Foster C, Dominguez S, Tagarro A, Nastouli E, Gkouleli R, Heaney J, PalmaP, Rossi P, Giaquinto C, Rojo P Published: 10th IAS Conference on HIV Science, July 21rd-24th 2019,…
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Comparison of qPCR and dPCR methods to investigate the latent HIV reservoir in a paediatric population with long viral suppression on therapy

02 Sep, 2019

Authors: Heaney J, Busby E, Gärtner K, Grant P, Spyer MJ, O’Sullivan DM, Gkouleli T, Marcelin AG, Pillay D, Foster C, Rojo P, Palma P, Muñoz Fernández MA, deRossi A,…
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Neonatal ART < 7 days VS 7-28 days reduced time to suppression

28 Jul, 2019

Authors: Tagarro A, Dominguez Rodriguez S, Puthanakit T, et al. Published: Oral presentation at 27th Conference on Retroviruses and Opportunistic Infections, March 4th-7th, 2019 – Seattle, WA Abstract: Early antiretroviral…
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Time to viral suppression in perinatally HIV-infected infants depends on the state of HIV disease progression at start of ART

30 Mar, 2019

Authors: Schröter J. Published: Oral presentation at 26th International HIV Dynamics & Evolution, March 24th-27th, 2019, Cascais, PT
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Predictors of faster virological suppression in early treated infants with perinatal HIV from Europe and Thailand

25 Mar, 2019

Authors: Chan MK, Goodall R, Judd A, et al. Published in: Aids. 2019; 33(7):1155-1165 Objective To identify predictors of faster time to virological suppression among infants starting combination antiretroviral therapy (cART) early in infancy. Design Cohort study of…
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HIV specific B-cell memory persists in seronegative early treated children and is dominated by IgM-memory responses

31 Dec, 2018

Authors: Cotugno N, Morrocchi E, Pepponi I, et al. Published in: J Immunol. 2018; 200 (1 ) 182.34; Abstract Early initiation of ART in HIV vertically infected infants influences specific immunity…
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Time of ART initiation in perinatally HIV-infected children impacts on HIV-specific T cell functionality

02 Sep, 2018

Authors: Rinaldi S, Cotugno N, Pallikkuth S, Pahwa R, Palma P, Pahwa S Published in: J Immunol. 2018; 200(1):166 Abstract Early initiation of antiretroviral therapy (ART) in vertically HIV-infected children…
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Time to viral rebound after stopping art in children treated from infancy in cher

02 Sep, 2018

Authors: Violari A, Chan M, Otwombe KN, Panchia R, Jean-Philippe P, Gibb D, Cotton M, Babiker A Published: Oral presentation at 25th Conference on Retroviruses and Opportunistic Infections, March 4th…
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Lasting immune impacts of age at start of ART in vertically HIV-infected adolescents

02 Sep, 2018

Authors: Cameron M, Rinaldi S, Richardson B, Cotugno N, Williams S, Pallikkuth S, de Armas LR, Cameron C, Pahwa R, Palma P, Pahwa S Published: 25th Conference on Retroviruses and…
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Factors associated with HIV DNA levels in children starting antiretroviral therapy (ART) early in infancy

02 Sep, 2018

Authors: Chan M, Tagarro A, Zangari P, Ferns B, Foster C, De Rossi A, Nastouli E, Ángeles Muñoz-Fernández M, Gibb D, Rossi P, Giaquinto C, Babiker A , Palma P,…
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Human Immunodeficiency Virus (HIV) – Antibody Repertoire Estimates Reservoir Size and Time of Antiretroviral Therapy Initiation in Virally Suppressed Perinatally HIV-Infected Children

28 Aug, 2018

Authors: Rocca S, Zangari P, Cotugno N, et al. Published in: J Pediatric Infect Dis Soc.2018; 28. doi:10 Background Assays to estimate human immunodeficiency virus (HIV) reservoir size require large amounts of blood,…
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HIV specific IgM memory B-cells dominate in seronegative early-treated children

02 Aug, 2018

Authors: Cotugno N, Morrocchi E, Pepponi I, Rocca S, Cameron M, Rinaldi S, Di Cesare S, Pallikkuth S, Bernardi S, Klein N, Ananworanich J, Rossi P, Pahwa S, Palma P…
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Early and highly suppressive ART are main factors associated with low viral reservoir in European perinatally HIV infected children

26 Jun, 2018

Authors: Tagarro A, Chan M, Zangari P, et al; on behalf of the EPIICAL Consortium Published in: J Acquir Immune Defic Syndr. 2018;79(2):269-276 Background Future strategies aiming to achieve HIV-1 remission are likely to target…
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