EPIICAL

Viral response in HIV infected infants starting ART at 1 month in Southern Mozambique

13 Mar, 2020

Authors: Lain MG, Vaz P, Ismael N,  Cantarutti A, Porcu G, Palma P, Cotugno N, Bila D, Rinaldi S,  Pallikkuth S, Pahwa R, Taibo E, Esmeralda Karajeanes E, Giaquinto C,…
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ushr: Understanding suppression of HIV in R

28 Feb, 2020

Authors: Morris SE, Dziobek-Garrett L, Yates AJ and the EPIICAL consortium Published in: BMC Bioinformatics 2020;21(1):52 Background HIV/AIDS is responsible for the deaths of one million people every year. Although…
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Early ART-treated perinatally HIV-infected seronegative children demonstrate distinct long-term persistence of HIV-specific T and B cell memory

19 Feb, 2020

Authors: Cotugno N, Morrocchi E, Rinaldi S, et al; EPIICAL Consortium. Published in: AIDS. 2020 Feb 3. Objective To investigate long-term persistence of HIV-specific lymphocyte immunity in perinatally HIV-infected children treated within…
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Impact of early antiretroviral therapy initiation on HIV-specific CD4 and CD8 T cell function in perinatally infected children

19 Feb, 2020

Authors: Rinaldi S, Pallikkuth S, Cameron M, et al. Published in: J Immunol. 2020 Feb 1;204:540-549 Abstract Early initiation of antiretroviral therapy (ART) in vertically HIV-infected children limits the size…
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PD-1+ CD4 T cells are associated with HIV reservoir size and impaired function of T follicular helper cells in children and young adults on long-term viral control

30 Dec, 2019

Authors: S. Rinaldi, V. Dinh, S. Pallikkuth, L. De Armas, R. Pahwa, N. Cotugno, E. Nastouli, C. Foster, P. Palma, S. Pahwa Published in: Poster presented at 9th International Workshop…
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Reduced time to suppression among neonates with HIV initiating antiretroviral therapy within 7 days of age

14 Nov, 2019

Authors: Domínguez-Rodríguez S, Tagarro A. Palma P, et al. Published in: JAIDS 2019;82(5):483-490 Abstract There are limited data on infants with HIV starting antiretroviral therapy (ART) in the neonatal period. We investigated the association…
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Time to HIV suppression in perinatally infected infants depends on the viral load and CD4 T-cell percentage at the start of treatment

12 Nov, 2019

Authors: Schröter J. Published in: Poster presented at 4th Workshop on Virus Dynamics, October 21st-23rd, 2019 -Paris, FR
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Detection of very low levels of cell-associated HIV-1 RNA in well suppressed adolescents (CARMA study)

12 Oct, 2019

Authors: Gärtner K, Gkouleli T, Heaney J, et al; on behalf of the EPIICAL consortium Published: Poster presented at HIV Cure and Reservoir Symposium, September, 16th-20th, 2019 -Ghent, BE
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The CARMA Study: Children on early suppressive ART Total HIV-1 DNA quantitation 12 years post ART initiation

02 Sep, 2019

Authors: Foster C, Dominguez S, Tagarro A, Nastouli E, Gkouleli R, Heaney J, PalmaP, Rossi P, Giaquinto C, Rojo P Published: 10th IAS Conference on HIV Science, July 21rd-24th 2019,…
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Comparison of qPCR and dPCR methods to investigate the latent HIV reservoir in a paediatric population with long viral suppression on therapy

02 Sep, 2019

Authors: Heaney J, Busby E, Gärtner K, Grant P, Spyer MJ, O’Sullivan DM, Gkouleli T, Marcelin AG, Pillay D, Foster C, Rojo P, Palma P, Muñoz Fernández MA, deRossi A,…
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Neonatal ART < 7 days VS 7-28 days reduced time to suppression

28 Jul, 2019

Authors: Tagarro A, Dominguez Rodriguez S, Puthanakit T, et al. Published: Oral presentation at 27th Conference on Retroviruses and Opportunistic Infections, March 4th-7th, 2019 – Seattle, WA Abstract: Early antiretroviral…
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Time to viral suppression in perinatally HIV-infected infants depends on the state of HIV disease progression at start of ART

30 Mar, 2019

Authors: Schröter J. Published: Oral presentation at 26th International HIV Dynamics & Evolution, March 24th-27th, 2019, Cascais, PT
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Predictors of faster virological suppression in early treated infants with perinatal HIV from Europe and Thailand

25 Mar, 2019

Authors: Chan MK, Goodall R, Judd A, et al. Published in: Aids. 2019; 33(7):1155-1165 Objective To identify predictors of faster time to virological suppression among infants starting combination antiretroviral therapy (cART) early in infancy. Design Cohort study of…
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HIV specific B-cell memory persists in seronegative early treated children and is dominated by IgM-memory responses

31 Dec, 2018

Authors: Cotugno N, Morrocchi E, Pepponi I, et al. Published in: J Immunol. 2018; 200 (1 ) 182.34; Abstract Early initiation of ART in HIV vertically infected infants influences specific immunity…
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Time of ART initiation in perinatally HIV-infected children impacts on HIV-specific T cell functionality

02 Sep, 2018

Authors: Rinaldi S, Cotugno N, Pallikkuth S, Pahwa R, Palma P, Pahwa S Published in: J Immunol. 2018; 200(1):166 Abstract Early initiation of antiretroviral therapy (ART) in vertically HIV-infected children…
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Time to viral rebound after stopping art in children treated from infancy in cher

02 Sep, 2018

Authors: Violari A, Chan M, Otwombe KN, Panchia R, Jean-Philippe P, Gibb D, Cotton M, Babiker A Published: Oral presentation at 25th Conference on Retroviruses and Opportunistic Infections, March 4th…
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Lasting immune impacts of age at start of ART in vertically HIV-infected adolescents

02 Sep, 2018

Authors: Cameron M, Rinaldi S, Richardson B, Cotugno N, Williams S, Pallikkuth S, de Armas LR, Cameron C, Pahwa R, Palma P, Pahwa S Published: 25th Conference on Retroviruses and…
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Factors associated with HIV DNA levels in children starting antiretroviral therapy (ART) early in infancy

02 Sep, 2018

Authors: Chan M, Tagarro A, Zangari P, Ferns B, Foster C, De Rossi A, Nastouli E, Ángeles Muñoz-Fernández M, Gibb D, Rossi P, Giaquinto C, Babiker A , Palma P,…
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