Penta HIV Trials

I was like, oh my God, what happens if it doesn’t work’? Young people living with HIV, clinical trial participation and the truth economy

11 Sep, 2015

Authors: Bernays S, Seeley J, Paparini S, Rhodes T Published: BSA Medical Sociology Conference, York, 9-11 September 2015 (Paper ID No: W0012148)
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I am scared of getting caught up in my lie’: challenges to self-reported adherence for young people living with HIV

18 Jul, 2015

Authors:  Bernays S, Seeley J, Paparini S, Rhodes T and the ARROW and BREATHER trial teams. Published in: accepted for presentation at AIDS Impact, Amsterdam 28-31 July, 2015 (abstract 3435)
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Young people, clinical trials and ‘the HIV experience’: What can similarities across time and place tell us about growing up with HIV?

18 Jul, 2015

Authors:  Paparini S on behalf of Bernays S, Seeley S,  Rhodes T,  Namukwaya Kihika S,Kawuma-Kigawa R, Nakyambadde H, Kabajaasi O and the BREATHER Trial Team. Published in: 3rd International ASSHH Conference, Stellenbosch,…
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“But it’s my story”: exploring the experience and effect of telling children how they have acquired HIV

18 Jul, 2015

Authors:  Seeley J on behalf of the Bernays S, Paparini S, Namukwaya Kihika S,  Rhodes T and the BREATHER Trial Team. Published in: 3rd International ASSHH Conference, Stellenbosch, South Africa, 6-9…
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Once vs. twice-daily lopinavir/ritonavir in HIV-1-infected children.

19 Apr, 2015

Authors: Paediatric European Network for Treatment of AIDS (PENTA). Published in: AIDS 2015. 29(18):2447-2457 Objective To evaluate whether once daily (q.d.) lopinavir/ritonavir is noninferior to twice daily (b.i.d.) dosing in…
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ART With Weekends Off Is Noninferior to Continuous ART in Young People on EFV+2NRTI

23 Feb, 2015

Authors: Karina M. Butler on behalf of the BREATHER trial team Published in: CROI 2015, Seattle, USA, Feb 23 -26 2015. Abstract For HIV-1 infected young people (YP) facing lifelong ART,…
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Long-term consequences of planned treatment interruption in HIV-1-infected children.

18 Feb, 2015

Authors: Freguja R, De Rossi A, Paulson H, Klein N, Del Bianco P, Compagnucci A, Saidi Y, Giaquinto C, Harper L, Gibb D, on behalf of the PENTA Steering Committee…
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HIV-1 Drug Resistance and Second-line Treatment in Children Randomized to Switch at Low versus Higher RNA Thresholds

01 Jan, 2015

Authors: Harrison L, Melvin A, Fiscus S, et al; PENPACT-1 (PENTA 9PACTG 390) Study Team. Published in: J Acquir Immune Defic Syndr. 2015;70(1):42-53 Background The PENPACT-1 trial compared virologic thresholds to determine when…
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Using CD4 Percentage and Age to Optimize Pediatric Antiretroviral Therapy Initiation

18 Apr, 2014

Authors: Yin D., Warshaw M., Miller W., Castro H., Fiscus S., Harper L., Harrison L., Klein N., Lewis J., Melvin A., Tudor-Williams G., McKinney R. Published in: Pediatrics, 2014;134(4):e1104-16 Background Quantifying…
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Pharmacokinetics of Pediatric Lopinavir/Ritonavir Tablets in Children When Administered Twice Daily According to FDA weight bands.

10 Apr, 2014

Authors: Bastiaans DE, Forcat S, Lyall H, et al. Published in: Pediatr Infect Dis J. 2014;33(3):301-305 Background Lopinavir/ritonavir (LPV/r) pediatric tablets (100/25 mg) are approved by the United States Food and Drug Administration (FDA)…
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HIV-1 resistance after randomized virologic switch at 1,000 or 30,000 c/ml in children.

18 Mar, 2014

Authors: Harrison L, Gibb DM, Fiscus S, Saïdi Y, Nastouli E, Harper L, Compagnucci A, Babiker A, Melvin A, Tudor-Williams G and the PENPACT 1 (PENTA 9/PACTG 390) Study Team.…
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The Immunological and Virological Consequences of Planned Treatment Interruptions in Children with HIV Infection.

23 Oct, 2013

Authors: Klein N, Sefe D, Mosconi I, et al; on Behalf of the Paediatric European Network for Treatment of AIDS (PENTA) 11 Trial Team Published in: PLoS One. 2013;8(10):e76582. Objective…
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Pharmacokinetics of paediatric lopinavir/ritonavir tablets in children when administered twice daily according to FDA weight bands.

19 May, 2013

Authors: D Bastiaans, S Forcat, H Lyall, T Cressey, S Chalermpantmetagul, Y Saïdi, C Koenigs,  D Nayagam, A Compagnucci, S Montero, L Harper, C Giaquinto, E Colbers, D Burger. Published…
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Outcomes after reinitiating antiretroviral therapy in children randomized to planned treatment interruptions in the PENTA 11 Study

18 Feb, 2013

Authors: Bunupuradah T, Duong T, Compagnucci A, et al; on behalf of the PENTA 11 Extension Study Group Published in: AIDS. 2013;27(4):579-89 Background Excess risks for death/opportunistic disease in adults randomized…
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Adherence to antiretroviral therapy and acceptability of planned treatment interruptions in HIV-infected children

17 Jan, 2013

Here have been no paediatric randomised trials describing the effect of planned treatment interruptions (PTIs) of antiretroviral therapy (ART) on adherence, or evaluating acceptability of such a strategy. In PENTA…
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Pharmacokinetics of 100/25 mg lopinavir/ritonavir tablets in children when dosed twice daily according to FDA weight bands.

19 Jul, 2012

Authors: Bastiaans DET, Forcat S, Lyall HEG, Cressey TR, Chalermpantmetagul S, Saïdi Y, Noguera T, Fortuny C, Compagnucci A, Bleier J, Giaquinto C, Colbers EP, Burger DM. Published in: 4th…
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Neurocognitive and Quality of Life Outcomes in Children after Planned Treatment Interruptions: the randomized PENTA 11 trial.

08 May, 2012

Authors: Ramos J., Melvin D, Medin G, Compagnucci A, Bleier J, Boscolo V, Barclay L, Ory S, Giaquinto C, Gibb D. on behalf of the PENTA Steering Committee. Published in:…
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Pharmacokinetics of 100/25 mg lopinavir/ritonavir tablets in children when dosed twice daily according to FDA weightbands.

19 Apr, 2012

Authors: D Bastiaans, S. Forcat, H.E.G. Lyall, T.R. Cressey, S. Chalermpantmetagul, Y. Saïdi, H.J. Scherpbier, A. Warris, A. Compagnucci, C. Giaquinto, E.P. Colbers, D.M. Burger on behalf of PENTA KONCERT…
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