Penta HIV Trials

Age and CD4 Count at Initiation of Antiretroviral Therapy in HIV-InfectedChildren: Effects on Long-term T-Cell Reconstitution

28 Dec, 2011

Authors: Lewis J, Walker AS, Castro H, et al. Published in: J Infect Dis. 2011;205(4):548-556 Background Effective therapies and reduced AIDS-related morbidity and mortality have shifted the focus in pediatric…
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Long Term consequences of planned treatment interruptions in HIV infected children: Results from the TICCH (Treatment Interruption in Children with Chronic HIV-Infection )/PENTA 11 trial.

18 Jul, 2011

Authors: Compagnucci A. on behalf of the PENTA Steering Committee Published in: 3rd HIV Paediatric Workshop Rome 15-16 July 2011.
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First-line antiretroviral therapy initiation with a protease inhibitor versus non-nucleoside reverse transcriptase inhibitor combination and switch at higher versus low viral load in HIV-infected children: an open randomised controlled phase 2/3 trial.

18 Apr, 2011

Authors: The PENPACT-1 (PENTA 9 / PACTG 390) Study Team. Published in: Lancet Infectious Diseases. April: 2011, 273-283 Background Children with HIV will be on antiretroviral therapy (ART) longer than adults, and therefore the…
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Pharmacokinetic study of once-daily versus twice-daily abacavir and lamivudine in HIV type-1-infected children aged 3-<36 months.

19 Apr, 2010

Authors: Paediatric European Network for Treatment of AIDS (PENTA) Published in: Antivir Ther. 2010;15(3):297-305. Background Once-daily dosing of abacavir and lamivudine has been approved for adults, but paediatric data are…
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A Model-based approach to dose selection in early pediatric development

19 Apr, 2010

Authors: Cella M, Gorter de Vries F, Burger D, Danhof M, Della Pasqua O. Published in: Clinical Pharmacology and Therapeutics, 2010, 87(3):294-302. Abstract The establishment of a rationale for determining…
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Immunologic and viral dynamics among HIV-infected children after planned treatment interruption: a substudy of the Paediatric European Network for Treatment of AIDS (PENTA) 11 trial.

18 Apr, 2010

Authors: Sefe D, Klein N, Mosconi I, Ricci E, Castro, H (nee Green), Jacobsen M, Bernardi S, Pillay D, Gibb DM, and De Rossi A, on behalf of the PENTA…
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PENTA and IMPAACT: A phase II/III randomised, open-label trial of combination antiretroviral regimens and treatment-switching strategies in HIV-1-infected antiretroviral naïve children

18 Apr, 2010

PENTA and IMPAACT: A phase II/III randomised, open-label trial of combination antiretroviral regimens and treatment-switching strategies in HIV-1-infected antiretroviral naïve children Published in: XVIII International AIDS Conference, 22nd July 2010,…
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Response to Planned Treatment Interruptions in HIV-infection varies across Childhood in the PENTA 11 Trial

19 Jan, 2010

Authors: Paediatric European Network for Treatment of AIDS. Published in: AIDS. 2010;24(2):231-241. Objective To evaluate clinical, immunological and virological consequences of CD4-guided antiretroviral therapy (ART) planned treatment interruptions (PTIs) compared with continuous therapy in…
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PENTA 15: plasma pharmacokinetic study of once versus twice daily abacavir and lamivudine as part of combination antiretroviral therapy in HIV-1 infected children aged 3 to <36 months.

19 Nov, 2009

Authors: Jacqz-Aigrain, Farrelly L, Compagnucci A, Harrison L, Zhao W, Hamadache D, Welch S, Wintergerst U, Firtion G, Burger D Published in: CROI 2009. February 8-11, 2009. Palais des Congres…
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PENTA 15: Once-daily abacavir and lamivudine as part of combination antiretroviral therapy to 48 weeks in HIV-1 infected children aged 3 to 36 months.

19 Jul, 2009

Authors: Zhao W, Farrelly L, Compagnucci A, Harrison L, Jacqz-Aigrain E, Hamadache D, Welch S, Wintergerst U, Burger D on behalf of the PENTA Trial Steering Committee . Published in:…
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Adherence to ART and acceptability of planned treatment interruptions (PTI) in the PENTA 11 trial

19 Jul, 2009

Authors: Harrison L, Hamadache D, Bunupuradah T, Mazza A, Ramos Amador JT, Flynn J, Rampon O, Mellado Pena MJ, Floret D, Marczynska M, Puga A, Farrelly L, Riault Y, Lallemant…
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Treatment interruption in children with chronic HIV-infection: the results of the paediatric European network for treatment of AIDS (PENTA) 11 trial.

19 Nov, 2008

Authors: Gibb DM, Compagnucci A, Green H, Lallemant M, et al. Published in: Journal of the International AIDS Society 2008, 11(Suppl 1):O21 (10 November 2008)
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Plasma drug concentrations and virologic evaluations after stopping non-nucleoside reverse transcriptase inhibitors (NNRTIs) in HIV-1 infected children

19 May, 2008

Authors: Cressey TR, Green H, Khoo S, Treluyer J-M, Compagnucci A, Saidi Y, Lallement M, Gibb DM, Burger D. Published in: Clin Infect Dis 2008. 15;46(10):1601-8  Background The optimum strategy…
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Does Early Treatment Provide Long Term Benefit in HIV-1 Infected Infants? Five Year Outcomes in Children Treated Before 3 Months of Age in the PENTA 7 Trial.

18 Apr, 2007

Authors: Compagnucci A, Saïdi Y, Harper L, Blanche S, Gabiano C, de José Gomez I, Notheis G, Gibb DM, Giaquinto C and Faye A for the PENTA 7 committees Published…
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3TC+ABC maintains virological superiority over ZDV+3TC and ZDV+ABC beyond 5 years in children: the PENTA 5 trial

18 Apr, 2007

Authors: Gibb DM, Green H, Saidi Y, et al; on behalf of PENTA 5. Published in: AIDS.2007;21(8):947-955 Objective To describe the long-term efficacy over 5 years of regimens including combinations…
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Pharmacokinetic and virological evaluations after stopping NNRTIs in children: a substudy of the PENTA 11 (TICCH) trial

19 Aug, 2006

Authors:  Lallemant M, Burger D, Lyall H, Buck L, Compagnucci A, Ramos Amador J.T, Mellado Pena M, Fregonese F, Campbell S, Rampon O, Castelli-Gattinara G, Cressey, Khoo S, Tréluyer J.-M,…
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Adherence and acceptability of once daily lamivudine and abacavir in HIV-1 infected children

19 Apr, 2006

Authors: LeProvost M, Green H, Flynn J, et al; on behalf of the PENTA 13 study group. Published in: Pediatr Infect Dis J. 2006;25(6):533-7 Background Data on adherence to and…
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A randomised controlled trial of genotypic HIV drug resistance testing in HIV-1 infected children: the PERA (PENTA 8)

18 Apr, 2006

Authors: Aboulker J-P, Babiker A, Bacheler L, et al. On behalf of the PENTA 8 study group Published in: Antivir Ther. 2006;11(7):857-867 Objective To evaluate the longer-term utility of genotypic resistance testing in HIV-1-infected children with virological…
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