HIV

96 week follow-up of the PENTA 5 trial; comparing ZDV+3TC, ZDV+ABC and 3TC+ABC with or without NFV in ART naive children

18 Jul, 2002

Authors: Gibb DM, Walker AS, Giaquinto C, Harper L, Compagnucci A, Saidi Y, Aboulker JP, Babiker A, Debré M, Darbyshire JH on behalf of the PENTA 5 Steering Committee. Published…
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PENTA guidelines for the use of antiretroviral therapy in paediatric HIV infection.

19 Apr, 2002

Authors: Sharland M, Castelli Gattinara G, Tomas Ramos J, Blanche S, Gibb DM for the PENTA Steering Committee. Published in: HIV Med 2002; 3:215-226
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Biphasic decay of cell-associated HIV-1 DNA in HIV-1 infected children on antiretroviral therapy

18 Apr, 2002

Authors: De Rossi A, Walker AS, De Forni D, Gibb DM; Paediatric European Network for Treatment of AIDS (PENTA). Published in: AIDS. 2002;16(14):1961-1963
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Impact of HIV-1 subtypes on virologic response and emergence of drug resistance

18 Apr, 2002

Authors: Pillay D, Walker AS, Gibb DM, De Rossi A, Kaye S, Ait-Khaled M, Muñoz-Fernandez M, Babiker A. for the PENTA Steering Committee. Published in: J Infect Dis 2002; 186:…
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Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral naïve HIV-1 infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial)

18 Apr, 2002

Authors: Gibb DM, Walker AS, Kaye S, et al. Published in: Antivir Ther. 2002;7(4):293-303 Purpose and Methods To describe the evolution of resistance to zidovudine (ZDV), lamivudine (3TC), abacavir (ABC) and nelfinavir (NFV), 113 previously untreated children in…
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Increased thymic output after initiation of antiretroviral therapy in human immunodeficiency virus type 1-infected children in the Paediatric European Network for Treatment of AIDS (PENTA) 5 Trial

18 Apr, 2002

Authors: De Rossi A, Walker AS, Klein N, De Forni D, King D, Gibb DM. Published in: J Infect Dis 2002; 186:312-20 Abstract To investigate the thymic contribution to immune reconstitution during antiretroviral therapy (ART),…
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Comparison of dual nucleoside-analogue reverse-transcriptase inhibitor regimens with and without nelfinavir in children with HIV-1 who have not previously been treated: the PENTA 5 randomised trial

18 Apr, 2002

Authors: Paediatric European Network for Treatment of AIDS (PENTA) Published in: Lancet.2002;359(9308):733-740 Introduction Treatment options for children with HIV-1 are limited. We aimed to compare activity and safety of three…
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Difficulties in achieving suppression of viral replication in vertically HIV-1 infected infants early treated with d4T+ddI+NFV : The PENTA 7 Study.

18 Feb, 2002

Authors: Compagnucci A, Saidi Y, Chaix ML, et al. Published in: 9th Conference on Retroviruses and Opportunistic Infections February 24-28, 2002 – Seattle. Poster 809 – W.
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TREC Response to Antiretroviral Therapy in HIV-infected Children in the PENTA 5 Trial

18 Feb, 2002

Authors: De Rossi A, Klein N, Walker AS, De Forni D, Babiker A, King D, Gibb DM for the PENTA Group. Published in: 9th Conference on Retroviruses and Opportunistic Infections,…
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The Impact of HIV-1 Subtypes on Virological Response and Emergence of Resistance in the PENTA 5 Trial

18 Feb, 2002

Authors: Pillay D, Gibb DM, Walker AS, De Rossi A, Kaye S, Ait-Khaled M, Muñoz-Fernandez M, Babiker A for the PENTA Group. Published in: 9th Conference on Retroviruses and Opportunistic Infections,…
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Pharmacokinetics (PK) of Nelfinavir (NFV) and its Active Metabolite (M8) in Very Young Infants Infected with Human Immunodeficiency Virus (HIV)

18 Apr, 2001

Authors: Litalien C, Faye A, Compagnucci A, Jacqz-Aigrain E. Published in: Pediatric Academic Societies 2001 Annual Meeting, April 28th – May 1st 2001, Baltimore MD. Abstract 2609.
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Evolution of drug resistance in antiretroviral therapy-naïve children in PENTA 5

18 Apr, 2001

Authors: Loveday. C., Walker. A.S., Gibb. D.M., on behalf of the PENTA virology Group Published in:  Fifth International Workshop on HIV Drug Resistance and Treatment Strategies, 2001, Scottsdale, USA. Abstract …
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T cell repopulation in HIV infected children on highly active anti-retroviral therapy (HAART)

18 Apr, 2001

Authors: King D J.S., Gotch F M., Larsson-Sciard E. Published in: Clin Exp Immunol.2001;125(3):447-454 Abstract In this pilot study, we address the nature of the re-population of the T-cell compartment…
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Evaluation of Toxicity, Tolerability and Antiviral Activity of Early d4T+ddI+Nelfinavir (NFV) Therapy in HIV-1 Vertically Infected Infants : 24 Week Preliminary Results from the PENTA 7 Study

18 Feb, 2001

Authors: Faye A , Compagnucci A., Saidi Y; for the PENTA 7 Executive Committee Published in: 8th Conference on Retroviruses and Opportunistic Infections, February 4th-8th, 2001, Chicago. Poster 678
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Nelfinavir doses should be increased in infants less than 3 months

18 Jul, 2000

Authors: Litalien C. Giaquinto C. Faye A. Mechinaud F. Grosch I. Compagnucci A. Jacqz-Aigrain E. Published in: XIII International AIDS Conference July 9th-14th 2000, Durban, South Africa. Abstract Mo PEB 2213…
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Reconstitution of the T-cell Pool in Treated, HIV-infected Children

18 Apr, 2000

Authors: King D, Gibb DM, Gotch F, Larsson-Sciard E. Published in: 7th Conference on Retroviruses and Opportunistic Infections, January 30th- February 2nd, 2000, Abstract 322., San Francisco. Abstract 322
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Immune repopulation after HAART in previously untreated HIV-1 infected children

18 Apr, 2000

Authors: Gibb DM, Newberry A, Klein N, de Rossi A, Grosch-Wörner I, Babiker A Published in: Lancet.2000; 355: 1331-2 Abstract In 25 vertically HIV-infected children receiving highly-active antiretroviral therapy, a…
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A randomised trial evaluating three NRTI regimens with and without Nelfinavir in HIV-infected children: 48 week follow-up from the PENTA 5 trial

18 Apr, 2000

Authors: Gibb. D. M. for the PENTA 5 Executive and the PENTA Steering Committee. Published in: Oral presentation at 5th International Congress on Drug Therapy in HIV Infection, Glasgow 22-26 October 2000 also published…
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