Publications

Efavirenz pharmacokinetics during pregnancy and infant washout

30 Aug, 2019

Authors: Kreitchmann R, Schalkwijk S, Best B, et al. Published in: Antivir Ther. 2019;24(2):95-103 Background Limited data exist on efavirenz pharmacokinetics in HIV-positive pregnant women and neonatal washout. Methods HIV-infected pregnant women receiving…
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Evaluating darunavir/ritonavir dosing regimens for HIV-positive pregnant women using semi-mechanistic pharmacokinetic modelling

30 Aug, 2019

Authors: Schalkwijk S, Ter Heine R, Colbers A, et al. Published in: J Antimicrob Chemother. 2019;30 [Epub ahead of print] Background Darunavir 800 mg once (q24h) or 600 mg twice (q12h) daily…
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Neonatal ART < 7 days VS 7-28 days reduced time to suppression

28 Jul, 2019

Authors: Tagarro A, Dominguez Rodriguez S, Puthanakit T, et al. Published: Oral presentation at 27th Conference on Retroviruses and Opportunistic Infections, March 4th-7th, 2019 – Seattle, WA Abstract: Early antiretroviral…
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Minor groove binder modification of widely used TaqMan hydrolysis probe for detection of dengue virus reduces risk of false-negative real-time PCR results for serotype 4

14 Jul, 2019

Authors: Gray ER, Heaney J, Ferns RB, Sequeira PC, Nastouli E, Garson JA Published in: J Virol Methods. 2019;268:17-23 Abstract Dengue is a vector-transmitted viral infection that is a significant cause of morbidity and mortality in…
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Field diagnosis and genotyping of chikungunya virus using a dried reverse transcription loop-mediated isothermal amplification (LAMP) assay and MinION sequencing

07 Jul, 2019

Authors: Hayashida K, Orba Y, Sequeira PC, et al. Published in: PLoS Negl Trop Dis. 2019;13(6):e0007480 Abstract Detection and sequencing of chikungunya virus (CHIKV) genome was performed using a combination…
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Use of the WHO Access, Watch, and Reserve classification to define patterns of hospital antibiotic use (AWaRe): an analysis of paediatric survey data from 56 countries.

18 Jun, 2019

Authors: Hsia Y, Lee BR, Versporten A, et al; GARPEC and Global-PPS networks. Published in: Lancet Glob Health. 2019;7(7):e861-e871 Background Improving the quality of hospital antibiotic use is a major goal of WHO’s global…
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Hard to study, hard to treat: putting children at the centre of antibiotic research and development

05 Jun, 2019

Authors: Balasegaram M, Pécoul B, Gray G, Sharland M, Swaminathan S. Published in: Lancet Infect Dis. 2019;19(6):573-574 Abstract Newborn babies, infants, and children are substantially affected by antimicrobial resistance. Globally,…
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Islands as Hotspots for Emerging Mosquito-Borne Viruses: A One-Health Perspective

28 May, 2019

Authors: Mavian C, Dulcey M, Munoz O, Salemi M, Vittor AY, Capua I. Published in: Viruses. 2019; 11(1):11 Abstract During the past ten years, an increasing number of arbovirus outbreaks have…
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R&D for children’s antibiotics – a wake-up call

28 May, 2019

Authors: O’Brien S, Sharland M, Zaoutis T Published in: AMR CONTROL 2019-2020; online edition Abstract It is time to prioritize children’s needs in the context of antimicrobial resistance (AMR). Children,…
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Lipidomic analysis reveals serum alteration of plasmalogens in patients infected with ZIKA virus

14 May, 2019

Authors: Queiroz A,Dantas Pinto IF, Lima M, et al. Published in: Front Microbiol. 2019;10:753 Abstract Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the Flavivirus genus of the Flaviviridae family. Since the large outbreaks…
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Immunoglobulin-like Domain of HsFcμR as a Capture Molecule for Detection of Crimean-Congo Hemorrhagic Fever Virus- and Zika Virus-Specific IgM Antibodies

29 Apr, 2019

Authors: Rackow A, Ehmen C, von Possel R, et al. Published in: Clin Chem. 2019;65(3):451-461. Background The cellular surface molecule HsTOSO/FAIM3/HsFcμR has been identified as an IgM-specific Fc receptor expressed on lymphocytes. Here,…
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Incidence of switching to second-line antiretroviral therapy and associated factors in children with HIV: an international cohort collaboration

29 Apr, 2019

Authors: Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration. Published in: Lancet HIV. 2019;6(2):e105-e115. Background Estimates of incidence of switching to second-line antiretroviral therapy (ART) among children with HIV are necessary…
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Severe haematologic toxicity is rare in high risk HIV-exposed infants receiving combination neonatal prophylaxis.

29 Apr, 2019

Authors: European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group in EuroCoord Published in: HIV Med. 2019;20(5):291-307 Objectives Combination neonatal prophylaxis (CNP) is recommended in high‐risk situations for the prevention of mother‐to‐child…
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Prevalence and clinical outcomes of poor immune response despite virologically suppressive antiretroviral therapy among children and adolescents with HIV in Europe and Thailand: cohort study

29 Apr, 2019

Authors: Collins IJ; European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group in EuroCoord Published in: Clin Infect Dis. 2019; 28. pii: ciz253. doi: 10.1093/cid/ciz253. [Epub ahead of print] Background In…
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The use of polymyxins to treat carbapenem resistant infections in neonates and children

26 Apr, 2019

Authors: Thomas R, Velaphi S, Ellis S, et al. Published in: Expert Opin Pharmacother. 2019;20(4):415-422.  Introduction The incidence of healthcare-associated multidrug resistant bacterial infections, particularly due to carbapenem resistant organisms, has been on the rise…
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Effects of an antimicrobial stewardship intervention on perioperative antibiotic prophylaxis in pediatrics

26 Apr, 2019

Authors: Donà D, Luise D, La Pergola E, et al. Published in: Antimicrob Resist Infect Control. 2019;8:13.  Purpose This study aims to determine the effectiveness of anAntimicrobial Stewardship Program based on a…
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Reactivity of routine HIV antibody tests in children with perinatally acquired HIV-1 in England: cross-sectional analysis

26 Apr, 2019

Authors: Fidler KJ, Foster C, Lim EJ, et al.; for Collaborative HIV Paediatric Study (CHIPS) Steering Committee Published in: Pediatr Infect Dis J. 2019;38(2):146-148 Abstract We assessed HIV antibody prevalence in children with perinatally acquired HIV in England. Eighteen percent (10/55) of…
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Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms

26 Apr, 2019

Authors: Chiappini E, Bianconi M, Dalzini A, et al. Published in: Antimicrob Resist Infect Control. 2019;8:13 Background Premature aging and related diseases have been documented in HIV-infected adults. Data are now…
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