PentaTr@ining is an innovative training programme designed for healthcare professionals caring for children and young people living with HIV and/or congenital infections. The course integrates cutting-edge online distance learning with face-to-face workshops, using interactive presentations, webinars, quizzes and small group sessions to focus on problems from real clinical practice, giving participants the platform to discuss difficult scenarios in a supportive environment. The fundamental aim of the course is to deliver optimum improvement of competence in the management of HIV infected children by all healthcare workers.