Brain MRI and neurocognitive characteristics of children with perinatal HIV infection in Russia: a retrospective cross-sectional study
Authors: MB. García, L. Okhonskaya, E. Voronin, V. Rozenberg, M. Titova, T. Kovalenko, A. Turkova, IJ. Collins, S. Crichton, C. Velo Higueras, MI. Gonzalez-Tomé, JT. Ramos-Amador, AMD. Aragón, on behalf of the REACH/EPPICC research groups
Published in: ESPID
Method: Retrospective cross-sectional study, Republican Children’s Infectious Diseases Hospital (Saint Petersburg, Sept. 2013- July 2015)
39 consecutive children in routine follow up underwent Weschler Intelligence Scale for Children (WISC-III) assessment
Linked to clinical data including immune and virological status
MRI assessment were independently reviewed by 2 radiologists
- Presence and number of focal white matter (WM) lesions
- Diffuse WM hyperintensities
- Global or regional atrophy
WISC III profiles
Assess intelligence in school-age children: 12 subtests, 3 indexes: Verbal IQ (VIQ), Performance IQ (PIQ) and Full Scale IQ (FSIQ).
Conclusion: 1. Almost half of children had evidence of neuroradiological abnormalities but most had IQ scores within the average range except for few subtests scores. 2. A trend towards older age at ART initiation among children with MRI abnormalities but not statistically significant and not adjusted for other confounders. 3. These assessments may help identify children in need of developmental support and ART optimisation.