Stories
How the Penta experience changed the model of HIV care in Central America
Dr. Luis G Castaneda V, from El Salvador, shares his experience as attendee at Tr@inForPed course
It's a worthwhile journey
Dr Pauline Amuge, from Uganda, speaks about her experience as a young investigator
Severe infections and antimicrobial resistance
To know more about Penta’s activities on this field visit our “Severe infections and antimicrobial resistance webpage“
AMR: a major threat to children's health
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Globally, many children and newborns with severe infections have virtually no new treatment options. Additionally, there is a high level of resistance existing antibiotics, leading to an increased mortality rate for severe infections.
Collaboration with GARDP
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In collaboration with GARDP, Penta has recently completed recruitment for an observational study (NeoOBS) designed to identify which bacteria causes sepsis in newborns, their resistance patterns and the most frequently used antibiotics to treat the infections. Part of NeoOBS programme is NeoFosfo, a trial aimed at identifying safety of fosfomycine in neonates.
Severe infections and AMR in Africa
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Antimicrobial resistance is responsible for half of all sepsis-related deaths in newborns in hospital. Babies which survive these type of infections face the possibility of neurodevelopment deficits. There is an urgent need to prioritized neonatal infection research in terms of diagnosis, prevention and treatment options for severe neonatal bacterial infections.
Penta's strategy on tackling AMR
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Through observational and interventional clinical trials, Penta is committed to preventing multi-resistant severe infections in children and working to optimally manage those infections, improving mortality and clinical outcomes.
The history of Penta's research
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Penta has used its years of experience and learning in the field of HIV, and taken this approach into the antimicrobials field. Penta’s approach is unique because Penta works both in infection prevention and treatment. It is through this that Penta can make progress in improving clinical outcomes and reducing children’s mortality worldwide.
The burden of neonatal sepsis in india
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The burden of neonatal sepsis is particularly felt in India: incidence and fatality rate are very high if compared to high resource countries. Moreover, causative agents are often multidrug-resistant bugs. Policy makers, researchers, funders must work together to find the answers needed to improve clinical outcome of newborns in low-resource settings.
Penta's holistic view on antimicrobial resistance
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Penta’s holistic approach to severe infections makes our strategy unique. Penta works both on mother and child, working to prevent mother-to-child transmission, but also on the identification of optimal treatment for infected babies .
Bringing antibiotics back to routine clinical care
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Penta is committed to fight antimicrobial resistance, through a network of clinical sites working on observational trials in severe infections and antimicrobial resistance patterns. Observational studies allow the design and implementation of trials aiming to test routinely-used antibiotics as well as identify new antibiotics to optimally treat severe infections in children.
