CHIVA

Dolutegravir-based ART is superior to NNRTI- and PI-based ART in infants, children and adolescents living with HIV (combined results of the main trial and the ‘under 14kg’ cohort)

2021

Abstract

ODYSSEY

  • Internationalmulti-centre,randomised96-weeknon- inferiority trial
  • WeaimedtocompareefficacyandsafetyofDTG-basedART with standard-of-care in children and adolescents starting first-line ART (ODYSSEY A) or second-line (ODYSSEY B)

Main trial enrolled children≥14kg

  • Aim to enrol ≥700 children: 310 ODYSSEY A, 390 ODYSSEY B
  • Powered for efficacy (total population and A&B separately)
  • Once enrolment in the main trial was completed,
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