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19

Mar, 2021

Characteristics of SARS-CoV-2 patients dying in Italy Report based on available data on March 1st, 2021

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Authors: Luigi Palmieri, Elvira Agazio, Xanthi Andrianou, Pierfrancesco Barbariol, Antonino Bella, Eva Benelli, Luigi Bertinato, Matilde Bocci, Stefano Boros, Giovanni Calcagnini, Marco Canevelli, Federica Censi, Alessandra Ciervo, Elisa Colaizzo, Martina Del Manso, Corrado Di Benedetto, Chiara Donfrancesco, Massimo Fabiani, et al. Published in: Epicentro   Sample: The present report describes the characteristics of 96,149 SARS-CoV-2 patients dying in Italy*, as reported by the Integrated Covid-19 Surveillance System coordinated by the National Institute of Health-ISS. Geographic distribution across the 19 regions and 2 autonomous provinces of Trento and Bozen is presented […]

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19

Mar, 2021

Virological and immunological features of SARS COV 2 infected children who who developed neutralizing antibodies

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Authors: Nicola Cotugno, Alessandra Ruggiero, Francesco Bonfante, Paolo Rossi, Anita De Rossi, Paolo Palma et al. Published in: Cell Reports   Summary: As the global COVID-19 pandemic progresses, it is paramount to gain knowledge on adaptive immunity to SARS-CoV-2 in children to define immune correlates of protection upon immunization or infection. We analyzed anti-SARS-CoV-2 antibodies and their neutralizing activity (PRNT) in 66 COVID-19-infected children at 7 (±2) days after symptom onset. Individuals with specific humoral responses presented faster virus clearance and lower viral load associated with a reduced in vitro infectivity. […]

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23

Feb, 2021

What does 95% COVID-19 vaccine efficacy really mean?

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Author: Piero Olliaro Published in: The Lancet Introduction: It is imperative to dispel any ambiguity about how vaccine efficacy shown in trials translates into protecting individuals and populations. The mRNA-based Pfizer1,2 and Moderna3 vaccines were shown to have 94–95% efficacy in preventing symptomatic COVID-19, calculated as 100 × (1 minus the attack rate with vaccine divided by the attack rate with placebo). It means that in a population such as the one enrolled in the trials, with a cumulated COVID-19 attack rate over a period of 3 months of about […]

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