News

23

Jul, 2021

CARMA study publishes article in Journal of International AIDS Society

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The CARMA team in the EPIICAL consortium have just published the article Early ART initiation during infancy preserves natural killer cells in young European adolescents living with HIV (CARMA cohort) in the Journal of International AIDS Society. HIV infection causes pathological changes in the natural killer cell compartment, a type of white blood cell with enzymes that kill cells infected with a virus. Through antiretroviral therapy (ART), this compartment can be partially restored. The CARMA team looked into the characteristics and function of natural killer cells in children born with HIV and […]

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12

Mar, 2021

Sharing our understanding of the immune response of children living with HIV

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EPIICAL is proud to have presented four abstracts at the CROI conference this year, sharing updated information on viral decay and the immune response of children living with HIV who begin treatment early in life.   EFFECT OF HIV ON IMMUNE ACTIVATION AND EXHAUSTION IN CD4 AND CD8 T CELLS IN INFANTS Stefano Rinaldi, Vinh B. Dinh, Suresh Pallikkuth, Lesley D. Armas, Nadia Sitoe, Rajendra Pahwa, Nicola Cotugno, Paula Vaz, Paolo Palma, MariaGrazia Lain, Savita G. Pahwa DYNAMICS OF INTACT PROVIRAL SEQUENCES IN EARLY TREATED HIV-1 CLADE C–INFECTED INFANTS Catherine […]

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21

Jul, 2020

The CARMA study: early infant antiretroviral therapy—Timing impacts on total HIV-1 DNA quantitation 12 years later

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Authors: Foster C, Domínguez-Rodríguez S, Tagarro A, et al. For the Early Treated Perinatally HIV Infected Individuals: Improving Children’s Actual Life (EPIICAL) Consortium Published in: J Pediatr Infect Dis Soc. 2020 2020 Jul 17;piaa071 Background Strategies aimed at antiretroviral therapy (ART)–free remission will target individuals with a limited viral reser- voir. We investigated factors associated with low reservoir measured as total human immunodeficiency virus type 1 (HIV-1) DNA in peripheral blood mononuclear cells (PBMCs) in perinatal infection (PaHIV). Methods Children from 7 European centers in the Early Treated Perinatally HIV […]

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28

Feb, 2020

ushr: Understanding suppression of HIV in R

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Authors: Morris SE, Dziobek-Garrett L, Yates AJ and the EPIICAL consortium Published in: BMC Bioinformatics 2020;21(1):52 Background HIV/AIDS is responsible for the deaths of one million people every year. Although mathematical modeling has provided many insights into the dynamics of HIV infection, there is still a lack of accessible tools for researchers unfamiliar with modeling techniques to apply them to their own clinical data.

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19

Feb, 2020

New publications from EPIICAL Consortium

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Just published – data on T & B cell memory and T cell function in early-treated children in the Journal of Immunology and AIDS. Antiretroviral treatment (if started at an early stage) is able to reduce the amount of HIV virus in a child’s body. EPIICAL is studying the characteristics of the immune response and the amount of HIV virus, in children with HIV who are treated at an early stage. This is to outline treatment strategies to help find a cure for HIV. Congratulations to all the authors!

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4

Oct, 2019

‘EARTH’ study – first patient enrolled in Mali

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We are delighted to report that the Centre Hospitalier Universitaire Gabriel Touré in Mali has enrolled its first patient in the key EPIICAL study, EARTH. This marks a new chapter in the study, with the scope of the cohort widening to include participants not only from South Africa and Mozambique, but also from the west African site in Bamako.

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15

Mar, 2019

CROI 2019: Oral presentation by members of the EPIICAL team

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The annual Conference on Retroviruses and Opportunistic Infections (CROI) was held on 4-7 March 2019, at the Washington State Convention Center in Seattle, Washington. At this year’s event, EPIICAL team member Sara Dominguez Rodriguez delivered an engaging oral presentation on the earliest antiretroviral therapy initiation in infants.

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1

Mar, 2019

CROI: Members of the EPIICAL team to attend in Seattle

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Seattle is gearing up for the 2019 edition of CROI next week. Held at Washington State Convention Center on 4th-7th March, the Conference on Retroviruses and Opportunistic Infections is an important event in the Penta calendar, and in particular for the EPIICAL consortium, as it is an opportunity for members to discuss the latest developments pertaining to the project. Included on the agenda, EPIICAL project researchers will make an oral presentation illustrating recent results that provide further evidence that supports the earliest ART initiation in infants.

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