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Authors: J. Loske, J. Röhmel, S. Lukassen, S. Stricker, V. G. Magalhães, J. Liebig, R. L. Chua, L. Thürmann, M. Messingschlager, A. Seegebarth, B. Timmermann, S. Klages, M. Ralser, B. Sawitzki, L. E. Sander, V. M. Corman, C. Conrad, S. Laudi, M. Binder, S. Trump, R. Eils, M. A. Mall and I. Lehmann Published in: Nature Biotechnology   Abstract Children have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection rates and a substantially lower risk for developing severe coronavirus disease 2019 compared with adults. However, the molecular mechanisms underlying […]

Authors: K Ali, GBerman, H Zhou, W Deng, V Faughnan, M Coronado-Voges, B Ding, J Dooley, B Girard, W Hillebrand, R Pajon, JM. Miller, B Leav, and R McPhee Published in: New England Journal of Medicine   Abstract Background The incidence of coronavirus disease 2019 (Covid-19) among adolescents between 12 and 17 years of age was approximately 900 per 100,000 population from April 1 through June 11, 2021. The safety, immunogenicity, and efficacy of the mRNA-1273 vaccine in adolescents are unknown. Methods In this ongoing phase 2–3, placebo-controlled trial, we randomly […]

Authors: E Molteni, CH Sudre, LS Canas, SS Bhopal, RC Hughes, M Antonelli, B Murray, K Kläser, E Kerfoot, L Chen, J Deng, C Hu, Somesh Selvachandran, Kenneth Read, Joan Capdevila Pujol, Prof Alexander Hammers, Prof Tim D Spector, Prof Sebastien Ourselin, Claire J Steves, Marc Modat, Michael Absoud, Prof Emma L Duncan Published in: The Lancet   Abstract  Background In children, SARS-CoV-2 infection is usually asymptomatic or causes a mild illness of short duration. Persistent illness has been reported; however, its prevalence and characteristics are unclear. We aimed to […]

Authors: O Irfan, J Li, K Tang, Z Wang, ZA Bhuta Published in: Journal of global health   Abstract Background There is uncertainty with respect to SARS-CoV-2 transmission in children (0-19 years) with controversy on effectiveness of school-closures in controlling the pandemic. It is of equal importance to evaluate the risk of transmission in children who are often asymptomatic or mildly symptomatic carriers that may incidentally transmit SARS-CoV-2 in different settings. We conducted this review to assess transmission and risks for SARS-CoV-2 in children (by age groups or grades) in […]

Authors: D Buonsenso, DD Giuda, L Sigfrid, DA Pizzuto, GD Sante, CD Rose, I Lazzareschi, M Sali, F Baldi, DPR Chieffo, D Munblit, P Valentini Published in: The Lancet   Introduction Although more patients are surviving COVID-19, there are emerging data on a substantial proportion of patients with persisting, and often debilitating, symptoms and sequelae for months following acute COVID-19. This scenario is commonly referred to as post-acute sequelae of SARS-CoV-2 infection (PASC) or long COVID.1 Some of the most commonly reported symptoms are fatigue, weakness, breathlessness, chest pain, and concentration impairment. Several independent studies have shown the existence of PASC, […]

Authors: B Kampmann U Okomo Published in: The Lancet   Introduction Given the success of COVID-19 vaccines in preventing death and severe disease in adults  and their impact on community transmission, use in children and young people (CYP) inevitably requires consideration. Although severe COVID-19 is rare in CYP, they are affected by SARS-CoV-2 infection and the impacts of the COVID-19 pandemic, including education, mental health, and general wellbeing. As of late July, 2021, no COVID-19 vaccine is recommended for children younger than 12 years and safety and efficacy data from phase […]