News

30

Aug, 2021

Patient and public involvement in the conect4children project

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The active participation of children, young people and their carers is one of the key objectives of the c4c project, which encourages patients and their families to get involved in Patient and Public Involvement (PPI) activities, allowing them to have a say in how research is designed conducted and disseminated.

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24

Aug, 2021

Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study

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Authors: G Berberian, R Bologna, MG Pérez, A Mangano, PhD, M Costa, MSc, S Calligaris, MA Morales, C Rugilo, E Ruiz-Burga, C Thorne Published in: Sage Journals   Abstract There are gaps in understanding the causes and consequences of microcephaly. This paper describes the epidemiological characteristics, clinical presentations, and etiologies of children presenting microcephaly during the Zika outbreak in Argentina. This observational retrospective study conducted in the pediatric hospital of Juan P. Garrahan reviewed the medical records of 40 children presenting microcephaly between March 2017 and November 2019. The majority (60%) were males and born full-term. At first evaluation, […]

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23

Aug, 2021

3rd International Meeting on Childhood Tuberculosis 2021

 

As the only international European meeting focusing entirely on the prevention and treatment of TB in children and adolescents, ptbnet promises to provide the latest in the elimination of TB in children, access to drugs and child friendly formulations, 21st Century diagnostics and more.

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19

Aug, 2021

Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children

 

Authors: J. Loske, J. Röhmel, S. Lukassen, S. Stricker, V. G. Magalhães, J. Liebig, R. L. Chua, L. Thürmann, M. Messingschlager, A. Seegebarth, B. Timmermann, S. Klages, M. Ralser, B. Sawitzki, L. E. Sander, V. M. Corman, C. Conrad, S. Laudi, M. Binder, S. Trump, R. Eils, M. A. Mall and I. Lehmann Published in: Nature Biotechnology   Abstract Children have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection rates and a substantially lower risk for developing severe coronavirus disease 2019 compared with adults. However, the molecular mechanisms underlying […]

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16

Aug, 2021

Evaluation of mRNA-1273 SARS-CoV-2 Vaccine in Adolescents

 

Authors: K Ali, GBerman, H Zhou, W Deng, V Faughnan, M Coronado-Voges, B Ding, J Dooley, B Girard, W Hillebrand, R Pajon, JM. Miller, B Leav, and R McPhee Published in: New England Journal of Medicine   Abstract Background The incidence of coronavirus disease 2019 (Covid-19) among adolescents between 12 and 17 years of age was approximately 900 per 100,000 population from April 1 through June 11, 2021. The safety, immunogenicity, and efficacy of the mRNA-1273 vaccine in adolescents are unknown. Methods In this ongoing phase 2–3, placebo-controlled trial, we randomly […]

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12

Aug, 2021

Illness duration and symptom profile in symptomatic UK school-aged children tested for SARS-CoV-2

 

Authors: E Molteni, CH Sudre, LS Canas, SS Bhopal, RC Hughes, M Antonelli, B Murray, K Kläser, E Kerfoot, L Chen, J Deng, C Hu, Somesh Selvachandran, Kenneth Read, Joan Capdevila Pujol, Prof Alexander Hammers, Prof Tim D Spector, Prof Sebastien Ourselin, Claire J Steves, Marc Modat, Michael Absoud, Prof Emma L Duncan Published in: The Lancet   Abstract  Background In children, SARS-CoV-2 infection is usually asymptomatic or causes a mild illness of short duration. Persistent illness has been reported; however, its prevalence and characteristics are unclear. We aimed to […]

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9

Aug, 2021

Risk of infection and transmission of SARSCoV-2 among children and adolescents in households, communities and educational settings: A systematic review and meta-analysis

 

Authors: O Irfan, J Li, K Tang, Z Wang, ZA Bhuta Published in: Journal of global health   Abstract Background There is uncertainty with respect to SARS-CoV-2 transmission in children (0-19 years) with controversy on effectiveness of school-closures in controlling the pandemic. It is of equal importance to evaluate the risk of transmission in children who are often asymptomatic or mildly symptomatic carriers that may incidentally transmit SARS-CoV-2 in different settings. We conducted this review to assess transmission and risks for SARS-CoV-2 in children (by age groups or grades) in […]

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6

Aug, 2021

Evidence of lung perfusion defects and ongoing inflammation in an adolescent with post-acute sequelae of SARS-CoV-2 infection

 

Authors: D Buonsenso, DD Giuda, L Sigfrid, DA Pizzuto, GD Sante, CD Rose, I Lazzareschi, M Sali, F Baldi, DPR Chieffo, D Munblit, P Valentini Published in: The Lancet   Introduction Although more patients are surviving COVID-19, there are emerging data on a substantial proportion of patients with persisting, and often debilitating, symptoms and sequelae for months following acute COVID-19. This scenario is commonly referred to as post-acute sequelae of SARS-CoV-2 infection (PASC) or long COVID.1 Some of the most commonly reported symptoms are fatigue, weakness, breathlessness, chest pain, and concentration impairment. Several independent studies have shown the existence of PASC, […]

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5

Aug, 2021

COVID-19 vaccines for children in LMICs: another equity issue

 

Authors: B Kampmann U Okomo Published in: The Lancet   Introduction Given the success of COVID-19 vaccines in preventing death and severe disease in adults  and their impact on community transmission, use in children and young people (CYP) inevitably requires consideration. Although severe COVID-19 is rare in CYP, they are affected by SARS-CoV-2 infection and the impacts of the COVID-19 pandemic, including education, mental health, and general wellbeing. As of late July, 2021, no COVID-19 vaccine is recommended for children younger than 12 years and safety and efficacy data from phase […]

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2

Aug, 2021

Aetiology of acute respiratory infection in preschool children requiring hospitalisation in Europe—results from the PED-MERMAIDS multicentre case–control study

 

Authors: MK Vasconcelos, K Loens, L Sigfrid, E Iosifidis, C Epalza, D Donà, V Matheeussen, S Papachristou, E Roilides, M Gijon, P Rojo, C Minotti, L Da Dalt, S Islam, J Jarvis, A Syggelou, M Tsolia, MN Nyang’wa, S Keers, H Renk, AL Gemmel, C D’Amore, MC degli Atti, CRT Sánchez, F Martinón-Torres, S Burokienė, T Goetghebuer, V Spoulou, A Riordan, C Calvo, D Gkentzi, M Hufnagel, PJ Openshaw, MD de Jong, M Koopmans, H Goossens, M Ieven, PLA Fraaij, CGiaquinto, JA Bielicki, P Horby, M Sharland Published in: BMJ Journals   Abstract Background Both […]

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