Antibiotic use in neonatal care: measuring cumulative exposure in point prevalence surveys identifies high infant-level antibiotic exposure
17 Apr, 2023
Authors: Cook A, Bielicki J, and the NeoIPC Consortium Presented at: ECCMID 2023
Read MoreAntibiotics needed to treat multidrug-resistant infections in neonates
24 Nov, 2022
Authors: CM Williams PCM, Qazi SA, Agarwal R, Velaphi S, Bielicki JA, Nambiar S, Giaquinto C, Bradley J, Noel GJ, Ellis S, O’Brien S, Balasegaram M & Sharland M Published in:…
Read MoreOptimised versus standard dosing of vancomycin in infants with Gram-positive sepsis (NeoVanc): a multicentre, randomised, open-label, phase 2b, non-inferiority trial
03 Dec, 2021
Authors: Hill L.F, Clements M.N, Turner M.A, Donà D, Lutsar I, Jacqz-Aigrain E, Heath P.T, Roilides E, Rawcliffe L, Alonso-Diaz C, Baraldi E, Dotta A, Ilmoja M, Mahaveer A, Metsvaht…
Read MoreGlobal estimates of the relative pediatric consumption and cost of oral amoxicillin and amoxicillin plus clavulanic acid
20 Jul, 2021
Authors: G. A. Levine, M. Sharland, S. Ellis, Y. Ferrisse, C. Loze, Y. Hsia, G. Fink, J. Bielicki; for the PediCAP project Published in: ECCMID 2021 Abstract Background: Amoxicillin…
Read MoreHarmonising regulatory approval for antibiotics in children
21 Jan, 2021
Authors: Phoebe C M Williams, John Bradley, Emmanuel Roilides, Linus Olson, Sheldon Kaplan, Irja Lutsar, Carlo Giaquinto, Daniel K Benjamin, Mike Sharland Published in: The Lancet Introduction: Antimicrobial resistance represents a substantial…
Read MoreGlobal sales of oral antibiotics formulated for children
02 Jul, 2020
Authors: Li G, Jackson C, Bielicki J, Ellis S, Hsiac Y, Sharland M Published in: Bulletin of the World Health Organization, July 2020 Objective To investigate international consumption patterns of…
Read MoreA comparison of five paediatric dosing guidelines for antibiotics
28 Apr, 2020
Authors: Mathur S, Jackson C, Urus H, Ziarko I, Goodbun M, Hsia Y, Ellis S, Sharland M. Published in: Bulletin of the World Health Organization, April 2020 Objective To compare…
Read MoreInterim pharmacokinetic analysis of a multi-centre randomised open label phase IIb study in neonates to validate the meta-analysis population pharmacokinetic model used to simulate an optimised dosing regimen in neonates and infants aged < 90 days: the NeoVanc trial
26 Apr, 2020
Authors: L. Hill, E. Jacqz-Aigrain, V. Elie, W. Zhao, M. Clements, M. Turner, I. Lutsar, P. Heath, E. Roilides, S. Walker, M. Sharland Published in: 30th European Congress on Clinical…
Read MoreAn optimised dosing regimen vs. a standard dosing regimen of vancomycin for the treatment of late onset sepsis due to Gram-positive microorganisms in infants less than 90 days: the NeoVanc trial
26 Apr, 2020
Authors: L. Hill, M. Clements, M. Turner, I. Lutsar, E. Jacqz-Aigrain, P. Heath, E. Roilides, S. Walker, M. Sharland Published in: 30th European Congress on Clinical Microbiology and Infectious Diseases…
Read MoreApplication of WISCA (Weighted Incidence Syndromic Combination Antibiogram) to guide empiric therapy in oncological paediatric patients with febrile neutropenia
26 Apr, 2020
Authors: E. Barbieri, D. Bottigliengo, P. Costenaro, A. Marzollo, M. Petris, M. Pierobon, G. Biddeci, C. Giaquinto, A. Biffi, D. Donà Published in: 30th European Congress on Clinical Microbiology and…
Read MoreAntibiotic treatment for paediatric outpatients with community-acquired pneumonia: findings from 10 years of prescribing habits in Italy
26 Apr, 2020
Authors: P. Costenaro, A. Cantarutti, E. Barbieri, A. Scamarcia, A. Oletto, P. Sacerdoti, R. Lundin, L. Cantarutti, C. Giaquinto, D. Dona’ Published in: 30th European Congress on Clinical Microbiology and…
Read MoreAn optimised dosing regimen versus a standard dosing regimen of vancomycin for the treatment of late onset sepsis due to Gram-positive microorganisms in neonates and infants aged less than 90 days (NeoVanc): study protocol for a randomised controlled trial
21 Apr, 2020
Authors: Hill LF, Turner MA, Lutsar I, et al; NeoVanc Consortium. Published in: Trials. 2020;21(1):329
Read MoreImplementation and impact of pediatric antimicrobial stewardship programs: a systematic scoping review
10 Jan, 2020
Authors: Donà D, Barbieri E, Daverio M, Lundin R, Giaquinto C, Zaoutis T, Sharland M Published in: Antimicrob Resist Infect Control.2020;9:3 Background Antibiotics are the most common medicines prescribed to…
Read MoreStandardising neonatal and pediatric anitibiotic clinical trial design and conduct: the PENTA-ID network review
30 Dec, 2019
Authors: Folgori L, Lutsar I, Standing JF, et al. Published in: BMJ Open. 2019; 9:e032592 Abstract: Antimicrobial development for children remains challenging due to multiple barriers to conducting randomised clinical…
Read MoreTowards understanding global patterns of antimicrobial use and resistance in neonatal sepsis: insights from the NeoAMR network
16 Oct, 2019
Authors: Li G, Bielicki JA, Ahmed ASMNU, et al. Published in: Arch Dis Child.2091;0:1-6 Objective To gain an understanding of the variation in available resources and clinical practices between neonatal units (NNUs) in the low-income and…
Read MoreDifferential susceptibility of Staphylococcus epidermidis biofilms to vancomycin, daptomycin and linezolid between clinical Isolates from neonates and adults
15 Oct, 2019
Authors:Simitsopoulou M, Kadiltzoglou P, Kyrpitzi D, Roilides E. Published in: Int J Biol Med Res.2019;10(1):6591-6596 Abstract This study aimed to compare the effects of vancomycin, linezolid and daptomycin against planktonic…
Read MorePopulation pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants
14 Oct, 2019
Authors: Jacqz-Aigrain E, Leroux S, Thomson AH, et al. Published in: J Antimicrob Ther 2019; 74(8):2128-2138
Read MoreUse of the WHO Access, Watch, and Reserve classification to define patterns of hospital antibiotic use (AWaRe): an analysis of paediatric survey data from 56 countries.
18 Jun, 2019
Authors: Hsia Y, Lee BR, Versporten A, et al; GARPEC and Global-PPS networks. Published in: Lancet Glob Health. 2019;7(7):e861-e871 Background Improving the quality of hospital antibiotic use is a major goal of WHO’s global…
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