Age and CD4 Count at Initiation of Antiretroviral Therapy in HIV-InfectedChildren: Effects on Long-term T-Cell Reconstitution
28 Dec, 2011
Authors: Lewis J, Walker AS, Castro H, et al. Published in: J Infect Dis. 2011;205(4):548-556 Background Effective therapies and reduced AIDS-related morbidity and mortality have shifted the focus in pediatric…
Read More3TC+ABC maintains virological superiority over ZDV+3TC and ZDV+ABC beyond 5 years in children: the PENTA 5 trial
18 Apr, 2007
Authors: Gibb DM, Green H, Saidi Y, et al; on behalf of PENTA 5. Published in: AIDS.2007;21(8):947-955 Objective To describe the long-term efficacy over 5 years of regimens including combinations…
Read MoreRelationship between changes in thymic emigrants and cell-associated HIV-1 DNA in HIV-1 infected children initiating antiretroviral therapy
18 Apr, 2005
Authors: De Rossi A, Walker AS, De Forni D, Klein N, Dibb DM. Paediatric European Network for Treatment of AIDS (PENTA) Published in: Antivir Ther. 2005;10(1):63-71 Objectives and Methods To investigate the relationship between cell-associated HIV-1 dynamics…
Read MoreMaintaining the nelfinavir trough concentration above 0.8 mg/L improves virologic response in HIV-1-infected children
18 Apr, 2004
Authors: Burger DM, Bergshoeff A, de Groot R, et al; on behalf of the PENTA 5 study group. Published in: J Paediatr 2004;145(3):403-405 Abstract Differences in virologic response were compared…
Read MoreEffect of concurrent zidovudine use on the resistance pathway selected by abacavir-containing regimens
18 Apr, 2004
Authors: Lanier ER, Givens N, Stone C, et al. Published in: HIV Med. 2004;5(6):394-399 Objectives Abacavir (ABC) selects for four mutations (K65R, L74V, Y115F and M184V) in HIV‐1 reverse transcriptase…
Read MoreThree year follow-up of the PENTA 5 trial
18 Apr, 2003
Authors: Gibb DM, Giaquinto C, Walker AS, Harper L, Compagnucci A, Saidi Y, Moulinier C, Aboulker JP, Babiker AG, Debré M, Darbyshire JH on behalf of the PENTA 5 Executive Committee…
Read MoreRelationship between Cell-Associated HIV-1 DNA and Thymic Output in HIV-1 infected Children Initiating Antiretroviral Therapy in the PENTA 5 Trial
18 Apr, 2003
Authors: De Rossi A, Walker AS, De Forni D, Gibb DM on behalf of PENTA. Published in: 10th Conference on Retroviruses and Opportunistic Infections February 10th – 14th, 2003 –…
Read MoreAdherence to Prescribed Antiretroviral Therapy in Human Immunodeficiency Virus-Infected Children in the PENTA 5 Trial
18 Apr, 2003
Author: Gibb DM, Goodall RL, Giacomet V, McGee L, Compagnucci A, Lyall H. Paediatric European Network for Treatment of AIDS Steering Committee. Published in: Pediatr Infect Dis J. 2003;22(1):56-62 Background…
Read MoreZidovudine (ZDV) appears to prevent selection of K65R and L74V, mutations normally selected by Abacavir (ABC) mono- or combination therapies not containing ZDV
18 Sep, 2002
Authors: Ait-Khaled M, Lanier R, Richards N, Stone C, Griffin P, Gibb DM, Walker AS, Craig C, Loeliger E, Tisdale M Published in: 2002 International Meeting of the Institute of…
Read MoreAdherence to HAART in children: results from a questionnaire study of children in PENTA 5 trial
18 Jul, 2002
Authors: Giacomet V, Gibb DM, Goodall R, McGee L, Walker AS, Giaquinto C. Published in: XIV World AIDS Conference, 7th-12th July 2002, Barcelona, Spain. Poster TuPpB2050
Read More96 week follow-up of the PENTA 5 trial; comparing ZDV+3TC, ZDV+ABC and 3TC+ABC with or without NFV in ART naive children
18 Jul, 2002
Authors: Gibb DM, Walker AS, Giaquinto C, Harper L, Compagnucci A, Saidi Y, Aboulker JP, Babiker A, Debré M, Darbyshire JH on behalf of the PENTA 5 Steering Committee. Published…
Read MoreBiphasic decay of cell-associated HIV-1 DNA in HIV-1 infected children on antiretroviral therapy
18 Apr, 2002
Authors: De Rossi A, Walker AS, De Forni D, Gibb DM; Paediatric European Network for Treatment of AIDS (PENTA). Published in: AIDS. 2002;16(14):1961-1963
Read MoreImpact of HIV-1 subtypes on virologic response and emergence of drug resistance
18 Apr, 2002
Authors: Pillay D, Walker AS, Gibb DM, De Rossi A, Kaye S, Ait-Khaled M, Muñoz-Fernandez M, Babiker A. for the PENTA Steering Committee. Published in: J Infect Dis 2002; 186:…
Read MoreEvolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral naïve HIV-1 infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial)
18 Apr, 2002
Authors: Gibb DM, Walker AS, Kaye S, et al. Published in: Antivir Ther. 2002;7(4):293-303 Purpose and Methods To describe the evolution of resistance to zidovudine (ZDV), lamivudine (3TC), abacavir (ABC) and nelfinavir (NFV), 113 previously untreated children in…
Read MoreIncreased thymic output after initiation of antiretroviral therapy in human immunodeficiency virus type 1-infected children in the Paediatric European Network for Treatment of AIDS (PENTA) 5 Trial
18 Apr, 2002
Authors: De Rossi A, Walker AS, Klein N, De Forni D, King D, Gibb DM. Published in: J Infect Dis 2002; 186:312-20 Abstract To investigate the thymic contribution to immune reconstitution during antiretroviral therapy (ART),…
Read MoreComparison of dual nucleoside-analogue reverse-transcriptase inhibitor regimens with and without nelfinavir in children with HIV-1 who have not previously been treated: the PENTA 5 randomised trial
18 Apr, 2002
Authors: Paediatric European Network for Treatment of AIDS (PENTA) Published in: Lancet.2002;359(9308):733-740 Introduction Treatment options for children with HIV-1 are limited. We aimed to compare activity and safety of three…
Read MoreTREC Response to Antiretroviral Therapy in HIV-infected Children in the PENTA 5 Trial
18 Feb, 2002
Authors: De Rossi A, Klein N, Walker AS, De Forni D, Babiker A, King D, Gibb DM for the PENTA Group. Published in: 9th Conference on Retroviruses and Opportunistic Infections,…
Read MoreThe Impact of HIV-1 Subtypes on Virological Response and Emergence of Resistance in the PENTA 5 Trial
18 Feb, 2002
Authors: Pillay D, Gibb DM, Walker AS, De Rossi A, Kaye S, Ait-Khaled M, Muñoz-Fernandez M, Babiker A for the PENTA Group. Published in: 9th Conference on Retroviruses and Opportunistic Infections,…
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