Age and CD4 Count at Initiation of Antiretroviral Therapy in HIV-InfectedChildren: Effects on Long-term T-Cell Reconstitution
28 Dec, 2011
Authors: Lewis J, Walker AS, Castro H, et al. Published in: J Infect Dis. 2011;205(4):548-556 Background Effective therapies and reduced AIDS-related morbidity and mortality have shifted the focus in pediatric…
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3TC+ABC maintains virological superiority over ZDV+3TC and ZDV+ABC beyond 5 years in children: the PENTA 5 trial
18 Apr, 2007
Authors: Gibb DM, Green H, Saidi Y, et al; on behalf of PENTA 5. Published in: AIDS.2007;21(8):947-955 Objective To describe the long-term efficacy over 5 years of regimens including combinations…
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Relationship between changes in thymic emigrants and cell-associated HIV-1 DNA in HIV-1 infected children initiating antiretroviral therapy
18 Apr, 2005
Authors: De Rossi A, Walker AS, De Forni D, Klein N, Dibb DM. Paediatric European Network for Treatment of AIDS (PENTA) Published in: Antivir Ther. 2005;10(1):63-71 Objectives and Methods To investigate the relationship between cell-associated HIV-1 dynamics…
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Maintaining the nelfinavir trough concentration above 0.8 mg/L improves virologic response in HIV-1-infected children
18 Apr, 2004
Authors: Burger DM, Bergshoeff A, de Groot R, et al; on behalf of the PENTA 5 study group. Published in: J Paediatr 2004;145(3):403-405 Abstract Differences in virologic response were compared…
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Effect of concurrent zidovudine use on the resistance pathway selected by abacavir-containing regimens
18 Apr, 2004
Authors: Lanier ER, Givens N, Stone C, et al. Published in: HIV Med. 2004;5(6):394-399 Objectives Abacavir (ABC) selects for four mutations (K65R, L74V, Y115F and M184V) in HIV‐1 reverse transcriptase…
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Three year follow-up of the PENTA 5 trial
18 Apr, 2003
Authors: Gibb DM, Giaquinto C, Walker AS, Harper L, Compagnucci A, Saidi Y, Moulinier C, Aboulker JP, Babiker AG, Debré M, Darbyshire JH on behalf of the PENTA 5 Executive Committee…
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Relationship between Cell-Associated HIV-1 DNA and Thymic Output in HIV-1 infected Children Initiating Antiretroviral Therapy in the PENTA 5 Trial
18 Apr, 2003
Authors: De Rossi A, Walker AS, De Forni D, Gibb DM on behalf of PENTA. Published in: 10th Conference on Retroviruses and Opportunistic Infections February 10th – 14th, 2003 –…
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Adherence to Prescribed Antiretroviral Therapy in Human Immunodeficiency Virus-Infected Children in the PENTA 5 Trial
18 Apr, 2003
Author: Gibb DM, Goodall RL, Giacomet V, McGee L, Compagnucci A, Lyall H. Paediatric European Network for Treatment of AIDS Steering Committee. Published in: Pediatr Infect Dis J. 2003;22(1):56-62 Background…
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Zidovudine (ZDV) appears to prevent selection of K65R and L74V, mutations normally selected by Abacavir (ABC) mono- or combination therapies not containing ZDV
18 Sep, 2002
Authors: Ait-Khaled M, Lanier R, Richards N, Stone C, Griffin P, Gibb DM, Walker AS, Craig C, Loeliger E, Tisdale M Published in: 2002 International Meeting of the Institute of…
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Adherence to HAART in children: results from a questionnaire study of children in PENTA 5 trial
18 Jul, 2002
Authors: Giacomet V, Gibb DM, Goodall R, McGee L, Walker AS, Giaquinto C. Published in: XIV World AIDS Conference, 7th-12th July 2002, Barcelona, Spain. Poster TuPpB2050
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96 week follow-up of the PENTA 5 trial; comparing ZDV+3TC, ZDV+ABC and 3TC+ABC with or without NFV in ART naive children
18 Jul, 2002
Authors: Gibb DM, Walker AS, Giaquinto C, Harper L, Compagnucci A, Saidi Y, Aboulker JP, Babiker A, Debré M, Darbyshire JH on behalf of the PENTA 5 Steering Committee. Published…
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Biphasic decay of cell-associated HIV-1 DNA in HIV-1 infected children on antiretroviral therapy
18 Apr, 2002
Authors: De Rossi A, Walker AS, De Forni D, Gibb DM; Paediatric European Network for Treatment of AIDS (PENTA). Published in: AIDS. 2002;16(14):1961-1963
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Impact of HIV-1 subtypes on virologic response and emergence of drug resistance
18 Apr, 2002
Authors: Pillay D, Walker AS, Gibb DM, De Rossi A, Kaye S, Ait-Khaled M, Muñoz-Fernandez M, Babiker A. for the PENTA Steering Committee. Published in: J Infect Dis 2002; 186:…
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Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral naïve HIV-1 infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial)
18 Apr, 2002
Authors: Gibb DM, Walker AS, Kaye S, et al. Published in: Antivir Ther. 2002;7(4):293-303 Purpose and Methods To describe the evolution of resistance to zidovudine (ZDV), lamivudine (3TC), abacavir (ABC) and nelfinavir (NFV), 113 previously untreated children in…
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Increased thymic output after initiation of antiretroviral therapy in human immunodeficiency virus type 1-infected children in the Paediatric European Network for Treatment of AIDS (PENTA) 5 Trial
18 Apr, 2002
Authors: De Rossi A, Walker AS, Klein N, De Forni D, King D, Gibb DM. Published in: J Infect Dis 2002; 186:312-20 Abstract To investigate the thymic contribution to immune reconstitution during antiretroviral therapy (ART),…
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Comparison of dual nucleoside-analogue reverse-transcriptase inhibitor regimens with and without nelfinavir in children with HIV-1 who have not previously been treated: the PENTA 5 randomised trial
18 Apr, 2002
Authors: Paediatric European Network for Treatment of AIDS (PENTA) Published in: Lancet.2002;359(9308):733-740 Introduction Treatment options for children with HIV-1 are limited. We aimed to compare activity and safety of three…
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TREC Response to Antiretroviral Therapy in HIV-infected Children in the PENTA 5 Trial
18 Feb, 2002
Authors: De Rossi A, Klein N, Walker AS, De Forni D, Babiker A, King D, Gibb DM for the PENTA Group. Published in: 9th Conference on Retroviruses and Opportunistic Infections,…
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The Impact of HIV-1 Subtypes on Virological Response and Emergence of Resistance in the PENTA 5 Trial
18 Feb, 2002
Authors: Pillay D, Gibb DM, Walker AS, De Rossi A, Kaye S, Ait-Khaled M, Muñoz-Fernandez M, Babiker A for the PENTA Group. Published in: 9th Conference on Retroviruses and Opportunistic Infections,…
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