Coronavirus disease (COVID-19) outbreak

The COVID-19 epidemic is increasingly impacting Europe and several other countries worldwide. Penta is contributing to important collective global efforts in gathering real-time evidence for clinical management of patients affected by novel coronavirus (COVID-19), and for informing public health responses.

Together with our partners in PREPARE network and COMBACTE project, we have mobilized our network of paediatric clinical experts and collaborating sites in Europe and encouraged them to use the PREPARE-endorsed data collection tool for any children with possible novel coronavirus infections under their care. This tool is an electronic case report form (eCRF) that has been developed by ISARIC and WHO, in order to ensure the collection of standardised clinical data on patients hospitalised with suspected or confirmed infection with SARS-CoV-2. The data collected will be used for combined analysis to facilitate disease characterisation and inform clinical management and control.

To read more about the COVID-19 eCRF, visit the ISARIC website.


The PREPARE network, of which Penta is the paediatric gateway, has now mobilised to Outbreak Research Response Mode 3, the highest response mode, which foresees the implementation of clinical research projects to address the most important and urgent clinical research questions posed by specific infectious diseases outbreaks. As a result of this action, PREPARE and its partners have pulled together a project proposal within the Horizon 2020 research framework, which was successfully selected for funding. Launched on March 10th, the new RECOVER project aims to develop data and evidence-based knowledge on the SARS-CoV-2 epidemic, and translate these into recommendations for improved patient management and public health response measures.


Virtual CROI 2020 dedicated a special session on COVID-19 to present state-of-the-art of what is known about COVID-19 and its causative pathogen, SARS-CoV-2. This special session focused on the epidemiology and efforts in China; the global epidemiology and effort to control the outbreak; the virology of coronaviruses overall, molecular aspects of transmission to humans, and pathogenesis in mice models and parallels in humans; and the NIAID/NIH efforts to study novel coronaviruses and develop diagnostics, therapeutics, and vaccines.

The COVID-19 session is available to anyone as a webcast.

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