Analytical treatment interruption (ATI) is a crucial component of HIV cure research, but discussions have largely focused on adult populations. A recent expert opinion from the EPIICAL consortium, published in The Lancet HIV, addresses this gap by reviewing the safety and utility of ATI in children living with HIV.
Research has shown that children living with HIV who start treatment early can have a better chance of achieving long-lasting viral control, even without continuous medication. Studies have also revealed that early treatment can help limit the size of the HIV reservoir, a hiding place for the virus in the body. In some cases, early-treated children have even been able to maintain viral control without any medication for years. These findings suggest that early intervention could be a promising strategy for improving the long-term health of children with HIV.
By carefully considering the safety and ethical implications and by conducting well-designed studies, research into ATI in children could contribute to the development of new strategies to improve the lives of children living with HIV.
Watch this video by Louise Khun for more