Publications

12

Jan, 2021

Zika virus infection in pregnancy: a protocol for the join analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia

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Authors: A E Ades, Elizabeth B Brickley, Neal Alexander, David Brown, Thomas Jaenisch, Demócrito de Barros Miranda-Filho, Moritz Pohl, Kerstin D Rosenberger, Antoni Soriano-Arandes , Claire Thorne et al.

Published in: BMJ Journals

 

Abstract: 

Introduction    Zika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is to document the risks of adverse pregnancy and birth outcomes and the prevalence of laboratory markers of congenital infection in deliveries to women experiencing ZIKV infection during pregnancy, using data from European Commission-funded prospective cohort studies in 20 centres in 11 countries across Latin America and the Caribbean.

Methods and analysis    We will carry out a centre-by- centre analysis of the risks of adverse pregnancy and birth outcomes, comparing women with confirmed and suspected ZIKV infection in pregnancy to those with no evidence of infection in pregnancy. We will document the proportion of deliveries in which laboratory markers of congenital infection were present. Finally, we will investigate the associations of trimester of maternal infection in pregnancy, presence or absence of maternal symptoms of acute ZIKV infection and previous flavivirus infections with adverse outcomes and with markers of congenital infection. Centre-specific estimates will be pooled using a two-stage approach.

Ethics and dissemination   Ethical approval was obtained at each centre. Findings will be presented at international conferences and published in peer-reviewed open access journals and discussed with local public health officials and representatives of the national Ministries of Health, Pan American Health Organization and WHO involved with ZIKV prevention and control activities.

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2

Nov, 2020

Vertical transmission of Zika virus and its outcomes: a Bayesian synthesis of prospective studies

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Authors: A E Ades, Antoni Soriano-Arandes, Ana Alarcon, Francesco Bonfante, Claire Thorne, Catherine S Peckham, Carlo Giaquinto

Published in: The Lancet

Abstract
Background:  Prospective studies of Zika virus in pregnancy have reported rates of congenital Zika syndrome and other adverse outcomes by trimester. However, Zika virus can infect and damage the fetus early in utero, but clear before delivery. The true vertical transmission rate is therefore unknown. We aimed to provide the first estimates of underlying vertical transmission rates and adverse outcomes due to congenital infection with Zika virus by trimester of exposure.

Methods: This was a Bayesian latent class analysis of data from seven prospective studies of Zika virus in pregnancy. We estimated vertical transmission rates, rates of Zika-virus-related and non-Zika-virus-related adverse outcomes, and the diagnostic sensitivity of markers of congenital infection. We allowed for variation between studies in these parameters and used information from women in comparison groups with no PCR-confirmed infection, where available.

Funding: European Union Horizon 2020 programme.

 

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17

Apr, 2020

Genomic and epidemiological surveillance of Zika virus in the Amazon region

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Authors: Giovanetti M, Faria NR, Lourenco J, et al.

Published in:  Cell Rep. 2020;30(7):2275-2283

Abstract Zika virus (ZIKV) has caused an explosive epidemic linked to severe clinical outcomes in the Americas. As of June 2018, 4,929 ZIKV suspected infections and 46 congenital syndrome cases had been reported in Manaus, Amazonas, Brazil. Although Manaus is a key demographic hub in the Amazon region, little is known about the ZIKV epidemic there, in terms of both transmission and viral genetic diversity. Using portable virus genome sequencing, we generated 59 ZIKV genomes in Manaus. Phylogenetic analyses indi- cated multiple introductions of ZIKV from northeastern Brazil to Manaus. Spatial genomic analysis of virus movement among six areas in Manaus suggested that populous northern neighborhoods acted as sources of virus transmission to other neighborhoods. Our study revealed how the ZIKV epidemic was ignited and maintained within the largest urban metropolis in the Amazon. These results might contribute to improving the public health response to outbreaks in Brazil.

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13

Feb, 2020

ZIKAction at 3rd International Conference on Zika Virus and Aedes related infections

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ZIKAction Consortium will be presenting preliminary results of its vertical transmission study at the 3rd International Conference on Zika Virus and Aedes related infections that will be held in Washington DC, USA, from 13th to 16th February 2020.

The conference aims to bring together physicians, public health practitioners and researchers to address challenges that Zika and Aedes related infections pose around the globe and try to fill knowledge gaps that still remain, despite many published papers.

Details of the ZIKAction presentations taking place at the conference are shown below.

 

Friday, February 14, 2020

  • Aileen Lue, Pediatric Medicine Resident, Bustamante Hospital for Children & University of the West Indies, Kingston, Jamaica. Severity and Outcomes of Dengue in Hospitalized Children from Five Hospitals in Jamaica During the 2018-2019 Epidemic: Is this due to Antibody Dependent Immune Enhancement from ZIKA Virus Exposure?
  • Karen Webster-Kerr, National Epidemiology Unit, Ministry of Health and Wellness, Kingston, Jamaica. Trends in Dengue – The Jamaican Experience.

 

Saturday, February 15, 2020

  • Celia DC Christie, Child and Adolescent Health, University of the West Indies, Kingston, Jamaica. Overview and Preliminary Results of the ZIKAction Vertical Transmission Study in Jamaica.

13

Feb, 2020

3rd International Conference on Zika virus and Aedes related infections

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The Third International Conference will include all Aedes related infections in addition to Zika. Aedes related infections have become a concern and continue to be a global threat: with epidemics significantly increasing in South America and western countries, including Europe being under threat. Recently Aedes related outbreak of Yellow Fever has been dominant in Brazil and several countries in Sub-Saharan Africa. In addition, although the prevalence of Zika virus is in decline, it is still in circulation around the globe and continues to pose a scientific challenge with numerous unanswered aspects. The disease has an enormous impact on mothers, families, childbearing women and travelers. Despite many published papers there remain a lot of gaps, even though new information is constantly coming to light.

This conferences aim to bring together physicians, public health practitioners and researchers in various related fields in order to share knowledge, discuss new findings and new ways to further proceed, with the goal of creating valuable collaborations.

The content of this conference will include: epidemiology and clinical aspects of Aedes related infections, gynecological aspects and follow up with children born to Zika infected mothers. In addition, virology aspects, diagnostic methods, new therapy and vaccine production as well as new methods of mosquito control all will be discussed in the meeting.

For more information, visit the conference website Third International Conference

14

Jul, 2019

Minor groove binder modification of widely used TaqMan hydrolysis probe for detection of dengue virus reduces risk of false-negative real-time PCR results for serotype 4

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Authors: Gray ER, Heaney J, Ferns RB, Sequeira PC, Nastouli E, Garson JA

Published in: J Virol Methods. 2019;268:17-23

Abstract Dengue is a vector-transmitted viral infection that is a significant cause of morbidity and mortality in humans worldwide, with over 50 million apparent cases and a fatality rate of 2.5 % of 0.5 million severe cases per annum in recent years. Four serotypes are currently co-circulating. Diagnosis of infection may be by polymerase chain reaction, serology or rapid antigen test for NS1. Both pan-serotype and serotype-specific genome detection assays have been described, however, achieving adequate sensitivity with pan-serotype assays has been challenging. Indeed, as we show here, inspection of components and cycling parameters of a pan-serotype RT-qPCR assay in use in laboratories worldwide revealed insufficient probe stability to accommodate potential nucleotide mismatches, resulting in false-negatives. A minor–groove binder (MGB)-modified version of the probe was designed and its performance compared with that of the original probe in 32 samples. Eight of the samples were undetected by the original probe but detected by the MGB modified probe and six out of seven of these that could be serotyped belonged to serotype 4. Sequencing of the region targeted by the probe in these samples revealed two mismatches which were also universally present in all other serotype 4 sequences in a public database. We therefore recommend adoption of this MGB modification in order to reduce the risk of false-negative results, especially with dengue serotype 4 infections.

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2

Jul, 2019

16th International course on Dengue, Zika and other emergent arboviruses

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The PAHO/WHO Collaborating Centre for the Study of Dengue and its Control of the Institute of Tropical Medicine “Pedro Kourí”/MINSAP, the Cuban Society of Microbiology and Parasitology, the Cuban Ministry of Public Health and PAHO/WHO have announced the 16th International Course on Dengue, Zika and Other Emergent Arboviruses. It will be held in Havana, Cuba from 12 – 23 August 2019.

Participants will include medical doctors, virologists, immunologists, social scientists, epidemiologists and entomologists and the aim, during the two-week course, will be to provide the latest scientific information on the regional and global epidemiological situation of important arboviruses, in particular dengue, Zika and chikungunya.

A prestigious faculty of professors from across the globe will present sessions and hold discussions on interesting and important topics including: clinical management, vector control, scientific advances in pathogenesis, vaccines and antiviral development, new vector control tools, the influence of host genetics as well as the genetics of the vector and the viruses, emergency control, new international initiatives for arbovirus control and prevention.

The deadline for registration is 20 July. You can find complete information about the course and registration here.

4

Jun, 2018

International Symposium on Zika Virus Research in Marseille – France

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Registrations are now open for the international conference on Zika Virus to be held in Marseille, France, next June. The event – organized by the EU-funded ZIKAlliance project in collaboration with three other EU-funded Zika projects (ZikaPLAN, ZIKAction, and ZIKAVAX) and the European Society for Virology – will take place at the Faculty of Medicine La Timone. The event will provide an overview of the current status of Zika research – covering from basic to clinical research, epidemiology, environmental studies and social sciences – and an opportunity to present the latest results from research conducted by the EU funded Zika consortia. Please visit the conference website for further details and register here.

15

Feb, 2018

What we know and what we don’t know about perinatal Zika virus infection: a systematic review

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Authors: Soriano-Arandes A, Rivero-Calle I, Nastouli E, et al.

Published in: Expert Rev Anti Infect Ther. 2018;16(3):243-254

Introduction: Zika virus (ZIKV) infection has caused the most challenging worldwide infectious epidemic outbreak in recent months. ZIKV causes microcephaly and other congenital malformations. There is a need to perform updated systematic reviews on ZIKV infection periodically because this epidemic is bringing up new evidence with extraordinary speed.

Areas covered: Evidence related to ZIKV infection in the gestational, perinatal, and early infant periods covering epidemiology, virology, pathogenesis, risk factors, time of infection during pregnancy, newborn symptoms, treatment, and vaccines. To this end, a search was performed using terms [‘Zika’] AND [‘Perinatal Infection’] OR [‘Congenital Infection’] in the PubMed® international electronic database. Out of a total of 1,538 articles published until 30 November 2017, we finally assessed 106 articles articles that were relevant to the research areas included in this study.

Expert commentary: ZIKV is a new teratogenic/neurotropic virus affecting fetuses. Many challenges are still far from being solved regarding the epidemiology, case definition, clinical and laboratory diagnosis, and preventive measures. An approach using ‘omics’ and new biomarkers for diagnosis, and a ZIKV-vaccine for treatment, might finally give us the tools to solve these challenges.

27

Nov, 2017

ZIKAction: approval of the Congenital Microcephaly Case-Control Study protocol

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On November 7th, 2017, the Ethics Committee of the Universidad Central del Ecuador formally approved the ZIKAction Congenital Microcephaly Case-Control Study protocol. This prospective study, focused on estimating the risk of congenital microcephaly associated with Zika virus, dengue or chikungunya infection, will be led by Dra. Greta Miño from Hospital del Niño Francisco Icaza Bustamante of Guayaquil and Dr. Toni Soriano from University Hospital Vall d’Hebron in Barcelona as co-lead of the ZIKA-PED work package.

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