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16

Mar, 2021

ZIKAHOST study shares findings on genetic predisposition to typical ZIKA effects at SEIP 2021

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The ZIKAHOST study aims to describe the Zika virus (ZIKV) infection taking into account the host, in this case humans, instead of the pathogen, which would be the zika virus, and we search for biomarkers of the increased likelihood of developing the disease, diagnosis and prognosis through a genomic approach. What this means is that we look at DNA to see if we could understand if patients can be genetically predisposed to develop typical ZIKV effects. The study analysed 80 DNA samples from 40 mother and child pairs. The mothers […]

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2

Nov, 2020

Vertical transmission of Zika virus and its outcomes: a Bayesian synthesis of prospective studies

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Authors: A E Ades, Antoni Soriano-Arandes, Ana Alarcon, Francesco Bonfante, Claire Thorne, Catherine S Peckham, Carlo Giaquinto Published in: The Lancet Abstract Background:  Prospective studies of Zika virus in pregnancy have reported rates of congenital Zika syndrome and other adverse outcomes by trimester. However, Zika virus can infect and damage the fetus early in utero, but clear before delivery. The true vertical transmission rate is therefore unknown. We aimed to provide the first estimates of underlying vertical transmission rates and adverse outcomes due to congenital infection with Zika virus by […]

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17

Apr, 2020

Genomic and epidemiological surveillance of Zika virus in the Amazon region

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Authors: Giovanetti M, Faria NR, Lourenco J, et al. Published in:  Cell Rep. 2020;30(7):2275-2283 Abstract Zika virus (ZIKV) has caused an explosive epidemic linked to severe clinical outcomes in the Americas. As of June 2018, 4,929 ZIKV suspected infections and 46 congenital syndrome cases had been reported in Manaus, Amazonas, Brazil. Although Manaus is a key demographic hub in the Amazon region, little is known about the ZIKV epidemic there, in terms of both transmission and viral genetic diversity. Using portable virus genome sequencing, we generated 59 ZIKV genomes in […]

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13

Feb, 2020

ZIKAction at 3rd International Conference on Zika Virus and Aedes related infections

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ZIKAction Consortium will be presenting preliminary results of its vertical transmission study at the 3rd International Conference on Zika Virus and Aedes related infections that will be held in Washington DC, USA, from 13th to 16th February 2020. The conference aims to bring together physicians, public health practitioners and researchers to address challenges that Zika and Aedes related infections pose around the globe and try to fill knowledge gaps that still remain, despite many published papers. Details of the ZIKAction presentations taking place at the conference are shown below.   […]

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14

Jul, 2019

Minor groove binder modification of widely used TaqMan hydrolysis probe for detection of dengue virus reduces risk of false-negative real-time PCR results for serotype 4

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Authors: Gray ER, Heaney J, Ferns RB, Sequeira PC, Nastouli E, Garson JA Published in: J Virol Methods. 2019;268:17-23 Abstract Dengue is a vector-transmitted viral infection that is a significant cause of morbidity and mortality in humans worldwide, with over 50 million apparent cases and a fatality rate of 2.5 % of 0.5 million severe cases per annum in recent years. Four serotypes are currently co-circulating. Diagnosis of infection may be by polymerase chain reaction, serology or rapid antigen test for NS1. Both pan-serotype and serotype-specific genome detection assays have been described, however, achieving adequate sensitivity with […]

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4

Jun, 2018

International Symposium on Zika Virus Research in Marseille – France

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Registrations are now open for the international conference on Zika Virus to be held in Marseille, France, next June. The event – organized by the EU-funded ZIKAlliance project in collaboration with three other EU-funded Zika projects (ZikaPLAN, ZIKAction, and ZIKAVAX) and the European Society for Virology – will take place at the Faculty of Medicine La Timone. The event will provide an overview of the current status of Zika research – covering from basic to clinical research, epidemiology, environmental studies and social sciences – and an opportunity to present the latest results […]

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15

Feb, 2018

What we know and what we don’t know about perinatal Zika virus infection: a systematic review

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Authors: Soriano-Arandes A, Rivero-Calle I, Nastouli E, et al. Published in: Expert Rev Anti Infect Ther. 2018;16(3):243-254 Introduction: Zika virus (ZIKV) infection has caused the most challenging worldwide infectious epidemic outbreak in recent months. ZIKV causes microcephaly and other congenital malformations. There is a need to perform updated systematic reviews on ZIKV infection periodically because this epidemic is bringing up new evidence with extraordinary speed. Areas covered: Evidence related to ZIKV infection in the gestational, perinatal, and early infant periods covering epidemiology, virology, pathogenesis, risk factors, time of infection during pregnancy, newborn symptoms, treatment, […]

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