News

29

Jan, 2021

Farewell to a great man

 

Penta joins our colleagues across the world in mourning the passing of our friend and research collaborator, Professor James Hakim, who died on 26 January 2021 from COVID-19 complications. He will be greatly missed by all those who had the privilege of knowing him. Professor Hakim was a prominent figure and pathfinder in the field of TB, HIV/AIDS and clinical research in Africa and his passing comes at a time where the importance of bringing HIV to the forefront has never been more significant for the world’s ability to achieve [...]
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26

Jan, 2021

Prof. Timo Vesikari talks to us about COVID-19 vaccines and children

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In December 2020 Penta held its annual Scientific Meeting. Despite the unusual get together due to COVID-19, we shared great science together. Among the experts invited was Timo Vesikari, a vaccine specialist who provided an insightful overview of the current scenario around COVID-19 vaccine development. He agreed to an interview with us and shed some light on our understanding of COVID-19 vaccines and how they impact children. Read the interview here

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Antimicrobial Resistance

21

Jan, 2021

Speeding up the development and approvals of new antibiotics for children

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In these difficult times, it is important to remain focused on improving outcomes for children with serious multidrug-resistant infections globally. Antimicrobial Resistance (AMR) represents a substantial threat to the Sustainable Development Goals (SDGs), with a large impact on the health of children worldwide. However, there is quieter limelight on the growing threat of AMR to child health. Carlo Giaquinto, Emmanuel Roilides,  Irja Lutsar, and Mike Sharland – members of Penta ID Network, along with other international researchers have published an article to highlight this issue and call for clear steps […]

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21

Jan, 2021

Harmonising regulatory approval for antibiotics in children

 

Authors: Phoebe C M Williams, John Bradley, Emmanuel Roilides, Linus Olson, Sheldon Kaplan, Irja Lutsar, Carlo Giaquinto, Daniel K Benjamin, Mike Sharland Published in: The Lancet Introduction: Antimicrobial resistance represents a substantial threat to the Sustainable Development Goals (SDGs), with a large impact on the health of children worldwide. However, very few paediatric trials for new antibiotics have been done to inform the optimal treatment of multidrug-resistant infections in children. The current drug regulatory framework has evolved from a system that rightly aimed to protect children, yet remains governed by interpretation of laws […]

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21

Jan, 2021

EU grants Marketing Authorisation to first-ever dispersible-tablet dolutegravir

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On 12 January 2021, the European Medicine Agency approved the use of dolutegravir 5mg dispersible tablets for treating HIV in young children living in Europe. This decision was based, in part, on data from our ODYSSEY trial, which we are conducting in close collaboration with the MRC CTU at the University College London. The EMA also authorised updating dosing recommendations for dolutegravir film-coated tablets (10mg, 25mg and 50mg) for children six years and older and weighing at least 14kg, bringing these in line with the World Health Organization weight bands. […]

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12

Jan, 2021

Zika virus infection in pregnancy: a protocol for the join analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia

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Authors: A E Ades, Elizabeth B Brickley, Neal Alexander, David Brown, Thomas Jaenisch, Demócrito de Barros Miranda-Filho, Moritz Pohl, Kerstin D Rosenberger, Antoni Soriano-Arandes , Claire Thorne et al. Published in: BMJ Journals   Abstract:  Introduction    Zika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is to document the risks of adverse pregnancy and birth outcomes and the prevalence of laboratory markers of congenital infection in deliveries to women experiencing ZIKV infection during pregnancy, using data from European […]

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