THRIVE

Over the last decade, collaborative efforts significantly expanded HIV treatment, leading to major breakthroughs in the global HIV market and accelerated access to key drug and diagnostic innovations. Despite this progress, many adult and paediatric patients living with Advanced HIV Disease (AHD) still die from preventable AIDS-related diseases – with children bearing a disproportionate burden.

To reduce AIDS-related deaths, THRIVE proposes a new approach focusing on local leadership and community-driven solutions. THRIVE will work in Kenya, Mozambique, Nigeria, South Africa, Uganda and Zimbabwe, and engage with national governments and global partners in order to create lasting impact through local empowerment.

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What is THRIVE?

THRIVE (Transforming Advanced HIV Disease CaRe in LMICs through ComprehensiVe and Equitable Access) is a project that aims to reduce mortality among adults and children living with HIV by enabling access to critical prevention, screening and treatment commodities. It does this by focusing on local leadership and community-owned solutions to find and serve people living with Advanced HIV Disease (AHD) where they are.

Why is THRIVE needed?

In 2022, 630,000 people died from AIDS – over one every minute. This alarming number of preventable deaths reveals the significant gap between global targets and real-world results.

To reduce morbidity and mortality, several ongoing challenges must be addressed, such as:

  • New AHD patients presenting late or re-engaging in care.
  • Insufficient access to diagnostic, prevention, and treatment tools.
  • Misdiagnosed and undiagnosed opportunistic infections (eg. Tuberculosis, Severe Bacterial Infections, Cryptococcal Meningitis).
  • Limited healthcare worker knowledge and confidence in identification and management of paediatric opportunistic infections.
  • Populations being left behind.

What is THRIVE’s goal?

THRIVE will tackle access barriers for adult and paediatric AHD care at global, regional, national and community levels. Specifically, the project will:

  • Generate evidence to guide policy and implementation approaches, ensuring that AHD care is accessible, practical and routine, particularly for children.
  • Accelerate access to and improve the usability of new and essential AHD products and resources.
  • Build country-level readiness and sustainability by working closely with governments, communities and local implementers.
  • Strengthen community engagement to effectively deliver AHD services.
  • Advocate to prioritise paediatric AHD on the global agenda.

As a project partner, Penta will lead the Paediatric Expert Advisory Network and develop training materials around paediatric AHD management.

This work was made possible with the support of Unitaid through the Clinton Health Access Initiative-led THRIVE project in partnership with AFROCAB and Penta. All views expressed within these materials are Penta’s own.