Maintaining the nelfinavir trough concentration above 0.8 mg/L improves virologic response in HIV-1-infected children
Authors: Burger DM, Bergshoeff A, de Groot R, et al; on behalf of the PENTA 5 study group.
Published in: J Paediatr 2004;145(3):403-405
Abstract Differences in virologic response were compared in 32 HIV-infected children with a nelfinavir trough concentration either below (n=7) or above (n=25) 0.8 mg/L. Virologic response at week 48 was observed in 29% of children with subtherapeutic nelfinavir troughs versus 80% in children with therapeutic nelfinavir troughs (P=.02)