PENTA 17 (Smile)

19

Jul, 2021

Once daily integrase inhibitor (INSTI) with boosted darunavir is non-inferior to standard of care in virologically suppressed children – Week 48 results of the SMILE Penta-17 Trial

 

Authors: Compagnucci A, Chan M, Saïdi Y, Cressey T, Bamford A, Riault Y, Coelho A, Nolan A, Chalermpantmetagul S, Amuge P, Musiime V, Violari A, Cotton M, Kekitiinwa A, Kaudha E,Groenewald M, Liberty A, Kanjanavanit S, Volokha A, Bologna R, Pavia Ruz N, Prieto Tato L, Paioni P, Marques L, Reliquet V, Welch S, Ford D, Giaquinto C, Gibb D, Babiker A, Ramos Amador JT, The SMILE-PENTA17-ANRS 152 Trial Group

Presented at: IAS 2021

 

Abstract

Background and overall aim: Current antiretroviral therapy (ART) guidelines recommend triple-drug ART as treatment of choice in HIV-infected adolescents and children with NRTI as backbone. However, NRTIs can be a potent source of adverse effects which are usually dose-related and cumulative. To reduce cumulative NRTI exposure in children, alternative NRTI-sparing ART regimens with a high generic barrier to resistance are available and may be an attractive switching option for children. The overall aim of SMILE is to evaluate antiviral efficacy and safety of once daily INSTI+DRV/r compared to current SOC therapy in HIV-1 infected, virologically suppressed paediatric participants.

Hypothesis: Children with chronic HIV infection on ART with suppressed viral load will maintain similar levels of viral suppression with once daily INSTI + DRV/r compared to continued standard of care triple ART.

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19

Jul, 2021

Once-Daily Integrase Inhibitor (Insti) With Boosted Darunavir is Non- Inferior to Standard of Care in Virogically Suppressed Children, Week 48 Results of the SMILE PENTA-17 Trial

 

Authors: Compagnucci A , Chan M , Saïdi Y , Cressey T , Bamford A , Riault Y , Coelho A , Nolan A ,Chalermpantmetagul S , Amuge P , Musiime V , Violari A , Cotton M , Kekitiinwa A , Kaudha E , Groenewald M, Liberty A , Kanjanavanit S , Volokha A , Bologna R , Muñoz Hernández R , Fortuny-Guasch C , Paioni P , Marques L , Reliquet V , Welch S , Ford D , Giaquinto C , Gibb D , Babiker A , Ramos Amador J and The SMILE-PENTA17-ANRS 152 Trial Group

Published in: International Workshop of HIV Pediatrics 2021

 

Abstract

Background:
– Children start ART very early and for life – Can we reduce number of drugs (sparing NRTIs)?
– Drugs with high genetic barrier to resistance are available for children

Overall Aim: To evaluate antiviral efficacy and safety of once daily INSTI+DRV/r compared to current SOC therapy in HIV-1 infected, virologically suppressed paediatric participants

Hypothesis: Children with chronic HIV infection on ART with suppressed viral load will maintain similar levels of suppression with once daily INSTI + darunavir/r compared to continued standard of care triple ART

View presentation slides

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