This calculator estimates the 12-month risks of progression to AIDS and death, based on the patient's age and one of the following markers: CD4 percent, CD4 count, total lymphocyte count, or viral load. The estimates should only be used for guidance on when to initiate ART, and not as a hard and fast rule. Such decisions should take account of other information, including the child's clinical status, the family's preparedness to start therapy, adherence, etc. See Penta Guidelines and AIDs Info Guidelines for further information.
Other important points to bear in mind when interpreting these estimates are:
Dunn D; HIV Paediatric Prognostic Markers Collaborative Study Group. Short-term risk of disease progression in HIV-1-infected children receiving no antiretroviral therapy or zidovudine monotherapy: a meta-analysis. Lancet. 2003 Nov 15;362(9396):1605-11.