PENTA 20 (Odyssey)

28

Sep, 2021

Dolutegravir-based ART is superior to NNRTI- and PI-based ART in infants, children and adolescents living with HIV (combined results of the main trial and the ‘under 14kg’ cohort)

 

Authors: Anna Turkova on behalf of the ODYSSEY trial team

Presented at: CHIVA 2021

 

Abstract

ODYSSEY

  • Internationalmulti-centre,randomised96-weeknon- inferiority trial
  • WeaimedtocompareefficacyandsafetyofDTG-basedART with standard-of-care in children and adolescents starting first-line ART (ODYSSEY A) or second-line (ODYSSEY B)

Main trial enrolled children≥14kg

  • Aim to enrol ≥700 children: 310 ODYSSEY A, 390 ODYSSEY B
  • Powered for efficacy (total population and A&B separately)
  • Once enrolment in the main trial was completed, the trial was opened for ‘under 14kg cohort’

‘Under 14kg’ cohort

  • Aim to enrol ≥20 children in each of the three lower WHO weight bands: 3-<6kg, 6-<10kg and 10-<14kg
  • To confirm efficacy, safety and the most practical dosing
  • Proportions of first- and second-line not pre-specified
  • Children in DTG arm did intensive PK

 

View presentation

20

Sep, 2021

PentaTr@ining kicks off HIV and other Congenital Infections course, in Spanish

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The Spanish language version of our online course “PentaTr@ining: HIV and other Congenital Infections” kicks off today! We look forward to welcoming over 100 participants for this year’s edition of our newly upgraded online training course.

Unique in its design and delivery, ‘PentaTr@ining’ is an innovative training platform which continues to develop and evolve in response to the changing needs of children, young people and pregnant women living with HIV and other congenital infections. Our flagship online course is highly interactive and clinical case based, designed to kindle engagement and foster intercommunication among the students and faculty team. It consists of 6 fortnightly modules with associated pictures, infographs, tables and figures, references and links to major paediatric infectious disease websites of interest. The modules are designed in a way that consolidates knowledge acquired as the course progresses, always encouraging the delegates to be proactive participants.

Visit the Pentatr@ining website for more information about our training initiatives.

15

Sep, 2021

Early Impact of SARS-CoV-2 on Pediatric Clinical Research: A Pan-European and Canadian Snapshot in Time

 

Authors: O L. Mantha, F. Flamein, M. Turner, R. M. Fernandes, R. Hankard, the Network of National Networks Study Group

Published in: The Journal od Pediatrics

 

Abstract

The article is meant to capture the early effects of the SARS-CoV-2 pandemic on pediatric clinical research.

Read full article

7

Sep, 2021

Project New Generation (PNG+)

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Project New Generation (PNG+) are a group of young people living with HIV who serve as the voice of the youth involved in the REACH study. Made up of two groups, one based in St. Petersburg and the other in Irkutsk, and supported by local psychologists, this group of 20 bring to the forefront, issues that the youth living with HIV are directly affected by. The activities of PNG+ are led by the Penta PPI team.

Pre-COVID-19, the PPI team held a number of in-person meetings with the young people, running training on Cohort Studies and understanding REACH, exploring the issues faced by young people living with HIV, Hepatitis C and TB and then looking at ways to share the findings from the study. Given the circumstances the world finds itself in today, the meetings moved to Zoom to continue the engagement, using similar techniques and approaches but tailoring the meetings to suit a digital format. Doing this has allowed the work to continue.

During the meetings, time was spent discussing how the key findings reflect what it’s like to be a young person living with HIV in Russia, and the group decided on the best ways to share the findings with young people living with HIV and their families across Russia. In between virtual meetings, the young people have been engaged via WhatsApp, sharing images and information to discuss and images and ideas for them to comment on. The PPI team have created an Instagram profile, @penta.youth which is being used to share the young people’s work and findings. The learning from this work it is now being rolled out across Penta’s other PPI work.

Young people having a voice and understanding of cohort studies and research is extremely important. The group reported that they enjoyed being a part of REACH and learning about studies. This group are keen to share their experiences and educate their peers and the general public. There is still much work to do to continue to build the relationship between them and medical professionals and develop robust youth engagement at all levels. Over the lifespan of REACH have seen the group grow and develop their soft skills such as confidence, teamwork, and communication. Our hope is to be able to continue engaging them with activities and opportunities in the future.

Here is to many more adventures with PNG+!

Find out more about PNG+ here

3

Sep, 2021

c4c podcast: The best kept secret of science communication

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The conect4children (c4c) project has recently released their third podcast, The best kept secret of science communication. This podcast, with speakers Claudio Fracasso and Lindesyt Hunter, the leads of the c4c communication, dissemination, exploitation and impact assessment working group, focuses on the importance of science communication, how it should be done to be effective and how to overcome the challenge of fake news, and its importance and central role in c4c.

You can listen directly to the podcast here.

3

Sep, 2021

Pediatric Vaccines and Vaccinations: A European Textbook available now

 

The second edition of Pediatric Vaccines and Vaccinations: A European Textbook, is now available for purchase! Included in this second edition is a new chapter covering COVID-19 vaccines.

Written by leading European experts, the textbook serves as a guide on vaccines and vaccinations in infants, children and adolescents. It aims to provide essential information on the current vaccines used in childhood immunization programs across Europe. Childhood and adolescent vaccine schedules, maternal and neonatal immunization and the safety of vaccines are covered in the first part of the book while the second part focuses on viral and bacterial vaccines. Other topics covered include pediatric travel vaccines, vaccines in the pipeline and the European registration process.

While this book is intended to be a reference textbook and will help with the standardization of information on vaccines and immunization programs in the WHO European Region, editors Timo Vesikari and Pierre van Damme state “

The textbook is available for purchase from the Springer website

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