Background: Vancomycin remains one of the most widely prescribed antibiotics for Gram-positive neonatal late onset sep- sis (LOS). Robust neonatal clinical outcome data comparing different vancomycin dosing regimens is lacking.…
Background: Vancomycin remains one of the most widely prescribed antibiotics for Gram-positive neonatal late onset sepsis (LOS), however, a consensus on optimal vancomycin dosing and duration is lacking. Robust neonatal…
Background: HIV has been shown to be independently associated with increased COVID-19 mortality in adults, but data in children and young people living with HIV (CYPLHIV) are limited. We assessed…
Abstract Background: Neural tube defects (NTDs) are known to be associated with maternal folate and vitamin B12 deficiency, and initial surveillance studies suggested an increased risk of NTDs among infants conceived…
Abstract Subphenotypes have been identified in several heterogeneous diseases. Having a specific subphenotype often has therapeutic implications or impacts disease progression. In this study, we aimed to assess if children…
Background: In 2015, Brazil experienced an unexpected increase in newborns with microcephaly. Subsequently, the association between microcephaly and Congenital Zika Infection (CZI) was confirmed. Aims: This study, part of the…
Great day for the D3 study, today. The first 2 children have been screened for the study at the Prapokklao Hospital in Thailand. Thanks to the MRC CTU and the…
Abstract Dolutegravir (DTG) is recommended and widely used during pregnancy for maternal viral suppression and preventing perinatal transmission of HIV. Our objective is to assess pregnancy and neonatal outcomes including…
Abstract The real-world evolution of very early treated children born with HIV in high-prevalence settings during first years of life is unclear. We assessed the probability of death, progression to…
Abstract ODYSSEY Internationalmulti-centre,randomised96-weeknon- inferiority trialWeaimedtocompareefficacyandsafetyofDTG-basedART with standard-of-care in children and adolescents starting first-line ART (ODYSSEY A) or second-line (ODYSSEY B) Main trial enrolled children≥14kg Aim to enrol ≥700 children: 310…
ODYSSEY has reached a major milestone by completing the recruitment of participants to the main trial. A big thank you to all the sites and everyone else for their hard…
We are thrilled to bring you the news that the Penta-sponsored clinical trial, SMILE, has hit its enrolment target with the recruitment of its 300th patient. The patient was enrolled at the Kryvyi…
A major new milestone has been achieved in the Penta-sponsored clinical trial SMILE, where patient No. 200 has been recruited today. The patient was enrolled at Baylor in Uganda.
The Penta-sponsored clinical trial SMILE has achieved a significant milestone by recruiting its 100th patient yesterday. The patient was enrolled at the Perinatal HIV Research Unit (PHRU) in Soweto, South…
We are pleased to celebrate the milestone achievement of the randomisation of 200 participants in the NeoVanc project. Congratulations to all the NeoVanc team!
September saw the CARMA study complete its enrollment target of 40 patients. Reservoir size assays have been performed, and primary statistical analyses are ongoing. Over the coming weeks, some results…
We are delighted to announce that the study PED-MERMAIDS has surpassed 50% of the enrollment target of 1,000 patients. This is a great achievement and we extend our thanks to…