Study update


Apr, 2022

The D3 study has screened the first 2 children


Great day for the D3 study, today. The first 2 children have been screened for the study at the Prapokklao Hospital in Thailand. Thanks to the MRC CTU and the PHPT team to coordinate this effort. Through D3, we aim to assess whether the combination of DTG/3TC is just as effective as the standard of care in terms of virological suppression in children and adolescents. The trial will also compare the toxicity, adherence, tolerability, acceptability and quality of life in participants of this combination versus that of the standard of […]



Apr, 2019

SMILE Clinical Trial: 100th Patient Enrolled

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The Penta-sponsored clinical trial SMILE has achieved a significant milestone by recruiting its 100th patient yesterday. The patient was enrolled at the Perinatal HIV Research Unit (PHRU) in Soweto, South Africa.  This is a wonderful result achieved through hard work and cooperation among the sites, the CTUs and the sponsor.



Oct, 2018

EPIICAL: enrollment has completed in the CARMA study!


September saw the CARMA study complete its enrollment target of 40 patients. Reservoir size assays have been performed, and primary statistical analyses are ongoing. Over the coming weeks, some results relating immunological and virological assays will be released and discussed internally within the EPIICAL Consortium at General Assembly meeting in November.



May, 2018

EARTH: first patient has been recruited!

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It is with great pleasure that we announce that the first patient in the EARTH study has been recruited. This encouraging news comes to us from the PHRU site in Soweto, South Africa. Now that all sites are open for recruitment, with some patients having already been screened, we are confident we will see more participants in the near future. This is the first of 150 children to be enrolled from one of 5 sites situated in South Africa and Mozambique. The EARTH project, nested within the EPIICAL platform, is a prospective multicentre, low-interventional study of HIV+ perinatally […]


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