EPIICAL

Probability of AIDS and non-AIDS-related mortality of early-treated children living with HIV-1

31 Aug, 2022

Authors: Bréhin,  Tagarro A,  Domínguez-Rodríguez S,  Kuhn L,  Nhampossa T,  Otwombe K,  Janse van Rensburg A,  Klein N,  Lain MN,  Maiga AI,  Giaquinto C,  Rossi P, Rojo P, EPIICAL Consortium…
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Joint evolution of CD4 and viral load trajectories over 2 years in an early-treated pediatric African cohort

29 Aug, 2022

Authors: Dominguez Rodriguez S, Ballesteros Á, Kuhn L, Nhampossa T, Otwombe K, Shaun Barnabas S,  Klein N, Lain M.G, Giaquinto C,  Rossi P, Rojo P, Tagarro A, EPIICAL Consortium Presented…
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Healthy dynamics of CD4 T cells may drive HIV resurgence in perinatally-infected infants on antiretroviral therapy

25 Aug, 2022

Authors: Sinead E. Morris, Renate Strehlau, Stephanie Shiau, Elaine J. Abrams, Caroline T. Tiemessen, Louise Kuhn, Andrew J. Yates on behalf of the EPIICAL consortium and LEOPARD study teams Published…
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Determinants of B-Cell Compartment Hyperactivation in European Adolescents Living With Perinatally Acquired HIV-1 After Over 10 Years of Suppressive Therapy

31 Mar, 2022

Authors: Ruggiero A, Pascucci G.R, Cotugno N, Domínguez-Rodríguez S, Rinaldi S, Tagarro A, Rojo P, Foster C, Bamford A, De Rossi A, Nastouli E, Klein N, Morrocchi E, Fatou B,…
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The subphenotypes of early-treated children living with HIV-1

18 Mar, 2022

Authors: S Domínguez-Rodríguez, A Tagarro, C Foster, P Palma, N Cotugno, AD Rossi, A Dalzini, SG. Pahwa, E Nastouli, K Gärtner, AG Marcelin, P Rossi, C Giaquinto, P Rojo Presented…
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2-year outcome of early treated infants in Sub-Saharan Africa

18 Mar, 2022

Authors: A Tagarro, S Domínguez-Rodríguez, L Kuhn, T Nhampossa, K Otwombe, AJv Rensburg, N Klein, MG Lain, AI. Maiga, C Brehin, C Giaquinto, P Rossi, P Rojo Presented at: CROI…
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Size of HIV-1 reservoir is associated with telomere shortening and immunosenescence in early-treated European children with perinatally acquired HIV-1

17 Dec, 2021

Authors: A Dalzini, G Ballin, S Dominguez-Rodriguez, P Rojo , M.R Petrara, C Foster, N Cotugno, A Ruggiero, E Nastouli, N Klein, S Rinaldi, S Pahwa, P Rossi, C Giaquinto,…
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Characterisation of the HIV proviral and inducible reservoir in well- suppressed children on long-term ART

06 Dec, 2021

Authors: Gärtner K, Byott M, Heaney J, Pagliuzza A, Spyer M.J Frampton D, Rossi A.D, Palmas P, Giaquinto C, Conejo P.R, Foster C,  Rossi P, Klein N, Chomont N, Nastouli…
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Early ART initiation during infancy preserves natural killer cells in young European adolescents living with HIV (CARMA cohort)

09 Jul, 2021

Authors: M Doria, S Zicari, N Cotugno, S Domínguez-Rodríguez, A Ruggiero, GR Pascucci, A Tagarro, PR Conejo, E Nastouli, K Gärtner, M Cameron, B Richardson, Ce Foster, SL Williams, S Rinaldi, AD Rossi, C Giaquinto, P Rossi, S Pahwa, P Palma, for the EPIICAL consortium Published in: Journal of the…
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The CARMA study: early infant antiretroviral therapy—Timing impacts on total HIV-1 DNA quantitation 12 years later

21 Jul, 2020

Authors: Foster C, Domínguez-Rodríguez S, Tagarro A, et al. For the Early Treated Perinatally HIV Infected Individuals: Improving Children’s Actual Life (EPIICAL) Consortium Published in: J Pediatr Infect Dis Soc.…
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The size of HIV reservoir is associated with telomere shortening and immunosenescence in early ART-treated HIV-infected children

13 Jul, 2020

Authors: De Rossi A, Dalzini A, Ballin G, Dominguez-Rodriuguez S, Rojo P, Foster C, Palma P, Sessa L, Nastouli E, Pahwa S, Rossi P, Giaquinto C, EPIICAL Consortium Published in:…
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Aging B-cells (ABC) and anti-Env humoral responses are associated with T-bet expression in B-cells of perinatally HIV infected children (PHIV) treated within 24 months (m) of life (the CARMA cohort)

13 Jul, 2020

Authors: Ruggiero A, Cotugno N, Domínguez-Rodríguez S,  Zicari S, Rinaldi S, Zangari P, Tagarro A, Foster C, De Rossi A, Nastouli E, Luzuriaga K, Giaquinto C, Rossi P, Pawha S,…
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A machine learning approach for predicting probability of death or disease progression in an early-treated pediatric African cohort

12 Jul, 2020

Authors: Domínguez-Rodríguez S, Tagarro A, Serna Pascual M, Otwombe K, Violari A, Fernández S, Nhampossa T, Lain M,  Vaz P , Behuhuma NO, Danaviah S, Dobbels E, Barnabas S, Cotugno…
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The HIV-1 antibody response: a footprint of the viral reservoir in children vertically infected with HIV

31 May, 2020

Authors: Palma P, McManus M, Cotugno N, Rocca S, Rossi P, Luzuriaga K Published in: Lancet HIV. 2020;7(5):e359-e365 Abstract Several assays have been developed to measure and characterise the replication-competent…
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Differences in inducibility of the latent HIV reservoir in perinatal and adult infection

12 May, 2020

Authors: Dhummakupt A, Rubens JH, Andeson T, et al. Published in: JCI Insight. 2020;5(4) Abstract The HIV latent reservoir in resting memory CD4+ T cells precludes cure. Therapeutics to reactivate…
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Differences in inducibility of the latent HIV reservoir in perinatal and adult infection

12 Apr, 2020

Authors: Dhummakupt A, Reubens JH, Anderson T, et al. Published: Poster presented at 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston. Abstract The HIV latent…
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Time to viral suppression in perinatally HIV-infected infants depends on the viral load and CD4 T-cell percentage at the start of treatment

27 Mar, 2020

Authors: Schröter J, Anelone A,  Yates A, de Boer RJ;  on behalf of the EPIICAL Consortium Published in: J Acquir Immune Defic Syndr. 2020;83(5):522-529   Background Interventions aiming for an…
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Mothers’ adherence helps in identifying more infants in need of extended prophylaxis

16 Mar, 2020

Authors: Dominguez-Rodriguez S, Rojo P, Lain MG,  Barnabas S, Lopez-Varela E, Otwombe K, Danaviah S, Nastouli E, Serna-Pasqual M, Gianuzzi V, Giaquointo C, Kuhn L, Tagarro A on behalf of…
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