SMILE (PENTA 17)

SMILE (PENTA 17)

Strategy for Maintenance of HIV suppression with integrase inhibitor + darunavir/ritonavir in children (PENTA 17).

SMILE is a multicentre randomised study evaluating safety and antiviral effect of a once daily integrase inhibitor administered with Darunavir/Ritonavir compared to standard of care among HIV-1 infected, virologically suppressed paediatric participants.

Penta is sponsor of this study, with 300 children due to be enrolled from about 30 sites from 10 countries.

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