Authors: Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration.
Published in: Lancet HIV. 2019;6(2):e105-e115.
Background Estimates of incidence of switching to second-line antiretroviral therapy (ART) among children with HIV are necessary to inform the need for paediatric second-line formulations. We aimed to quantify the cumulative incidence of switching to second-line ART among children in an international cohort collaboration.
Authors: Fidler KJ, Foster C, Lim EJ, et al.; for Collaborative HIV Paediatric Study (CHIPS) Steering Committee
Published in: Pediatr Infect Dis J. 2019;38(2):146-148
Abstract We assessed HIV antibody prevalence in children with perinatally acquired HIV in England. Eighteen percent (10/55) of those starting combination antiretroviral therapy <6 months of age were seronegative at median age 9.1 years and had lower viral load at diagnosis and combination antiretroviral therapy start and fewer viral rebounds,
Authors: Chiappini E, Bianconi M, Dalzini A, et al.
Published in: Antimicrob Resist Infect Control. 2019;8:13
Background Premature aging and related diseases have been documented in HIV-infected adults. Data are now emerging also regarding accelerated aging process in HIV-infected children.
Methods A narrative review was performed searching studies on PubMed published in English language in 2004-2017,
Authors: Collaborative Initiative for Paediatric HIV Education and Research (CHIPER) Global Cohort Collaboration
Published in: PLoS Med. 2018;15(3):e1002514.
Background Globally, the population of adolescents living with perinatally acquired HIV (APHs) continues to expand. In this study, we pooled data from observational pediatric HIV cohorts and cohort networks, allowing comparisons of adolescents with perinatally acquired HIV in “real-life” settings across multiple regions.
Authors: Marotta C, Giaquinto C, Di Gennaro F, et al.
Published in: BMC Public Health. 2018;18(1):703.
Background In 2013, Mozambique implemented task-shifting (TS) from clinical officers to maternal and child nurses to improve care for HIV positive children < 5 years old. A retrospective, pre-post intervention study was designed to evaluate effectiveness of a new pathway of care in a sample of Beira District Local Health Facilities (LHFs),
Authors: Ford D, Turner R, Turkova A, et al.
Published in: J Acquir Immune Defic Syndr. 2018;78(1):S40-S48.
Abstract For HIV-infected children, formulation development, pharmacokinetic (PK) data, and evaluation of early toxicity are critical for licensing new antiretroviral drugs; direct evidence of efficacy in children may not be needed if acceptable safety and PK parameters are demonstrated in children.
Authors: IeDEA and COHERE Cohort Collaborations.
Published in: Clin Infect Dis. 2018;66(6):893-903.
Background Early initiation of combination antiretroviral therapy (cART), at higher CD4 cell counts, prevents disease progression and reduces sexual transmission of human immunodeficiency virus (HIV). We describe the temporal trends in CD4 cell counts at the start of cART in adults from low-income,
Authors: Chiappini E, Galli L, Lisi C, et al.
Published in: J Acquir Immune Defic Syndr. 2018;79(1):54-61.
Background Strategies for prevention of HIV-1 mother-to-child transmission (PMTCT) have been continuously optimized. However, cases of vertical transmission continue to occur in high-income countries.
Objectives To investigate changes in PMTCT strategies adopted by Italian clinicians over time and to evaluate risk factors for transmission.
Authors: Judd A, Lodwick R, Noguera-Julian A, et al.. Pursuing Later Treatment Options II (PLATO II) Project Team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord.
Published in: HIV Med. 2017;18(3):171-180
Objectives The aim of the study was to determine the time to, and risk factors for,
Authors: Mbisa JL, Hue S, Buckton AJ, et al.
Published in: AIDS Res Hum Retroviruses. 2012;28(9):1161-1166
Abstract In the late 1980s an HIV-1 epidemic emerged in Romania that was dominated by subtype F1. The main route of infection is believed to be parenteral transmission in children. We sequenced partial pol coding regions of 70 subtype F1 samples from children and adolescents from the PENTA-EPPICC network of which 67 were from Romania.