HIV | EPIICAL

Presented by: Tagarro A, Reddy K, Molechan C, Dominguez-Rodriguez S, Smith T, Spyer M, Barnabas S, Lain M, Otwombe K, Nhampossa T, Maiga A, Rojo P, Giaquinto C, Rossi P, Ndung’u T, on behalf of the EPIICAL Consortium

Presented at: IAS (Oral presentation), IAS (Poster presentation), International Workshop on HIV and Pediatrics, Towards HIV Cure pre-meeting

Authors: Tagarro A, Reddy K, Barnabas S, Dominguez-Rodriguez S, Lain MG, Rojo P, Palma P, Ndung’u T, Spyer M, Nhampossa T, Otwombe K, Maiga A, Giaquinto C, Rossi P, on behalf of the EPIICAL Consortium

Presented at: ESPID 2025

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Authors: Tagarro A, Reddy K, Dominguez S, Barnabas S, Rojo P, Lain MG, Palma P, Cotugno N, Nastuoli E, Giaquinto C, N’Dungu T, Rossi P, on behalf of the EPIICAL Consortium

Presented at: ESPID 2025

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Authors: Rojo P, Moraleda C, Giaquinto C

Published in: Clinics in Perinatology

Authors: Tagarro A, Reddy K, Dominguez-Rodriguez S, Rojo P, Barnabas S, Otwombe K, Lain MG, Maiga A, Kuhn L, Palma P, Cotugno N, Nastuoli E, Giaquinto C, Ndung’u T, Rossi P; on behalf of the EPIICAL Consortium

Presented at: CROI

Authors: Landi A, D’Ambrosio F, Faggion S, Rocchi F, Paganin C, Lain MG, Ceci A, Giannuzzi V on behalf of the EPIICAL Consortium

Published in: Healthcare

Authors: Morrocchi E, Pascucci GR, Cotugno N, Pighi C, Dominguez-Rodriguez S, Petrara MR, Tagarro A, Kuhn L, Cotton MF, Otwombe K, Lain MG, Vaz P, Barnabas SL, Spyer MJ, Lopez E, Fernández-Luis S, Nhampossa T, Maiga AI, Dolo O, De Rossi A, Rojo P, Giaquinto C, Lichterfeld M, Violari A, Smit T, Behuhuma O, Klein N, De Armas L, Pahwa S, Rossi P, Palma P; EPIICAL consortium.

Published in: Scientific Reports

Authors: Petrara MR, Ruffoni E, Carmona F, Cavallari I, Zampieri S, Morello M, Del Bianco P, Rampon O, Cotugno N, Palma P, Rossi P, Giaquinto C, Giunco S, De Rossi A

Published in: PLOS Pathogens

Authors: Kuhn L, Barnabas S, Cotugno N, Peay H, Goulder P, Cotton M, Violari A, Pahwa S, Reddy K, Tagarro A, Otwombe K, Fry S, Vaz P, Lain GM, Nhampossa T, Archary M, Maiga IA, Puthanakit T, Kityo MC, Foster C, Rojo P, Klein N, Nastouli E, Tiemessen TC, Rossi dE, Ndung’u T, Persaud D, Lichterfeld M, Giaquinto C, Palma P, Rossi P, on behalf of the EPIICAL consortium

Published In: The Lancet HIV

Authors: Torres-Fernandez D, Domínguez-Rodríguez S, Fernández-Luis S, Nhampossa T, Lopez-Varela E, Naniche D, Lain GM, Ismael N, Spyer JM, Byott M, Nastouli E, Rossi P, Rojo P, Tagarro A on behalf of the EPIICAL Consortium.

Presented at: ESPID 2024

Authors: Torres-Fernandez D, Domínguez-Rodríguez S, Fernández-Luis S, Nhampossa T, Lopez-Varela E, Naniche D, Lain GM, Ismael N, Spyer JM, Byott M, Nastouli E, Rossi P, Rojo P, Tagarro A on behalf of the EPIICAL Consortium.

Presented at: ESPID 2024

Authors: Tagarro A, Domínguez-Rodríguez S, Cotton M, Otwombe K, Klein N, Lain GM, Nhampossa T, Maiga IA, Barnabas S, Vaz P, Violari A, Fernández-Luis S, Behuhuma O, Sylla M, López-Varela E, Naniche D, Janse-Van-Rensburg A, Liberty A, Ramsagar N, Smit T, Rojo P et al on behalf of EPIICAL consortium

Published in: eClinical Medicine

Authors: Reddy K, Molechan C, Dominguez-Rodriguez S, Smith T, Spyer M, Lichterfeld M, Rojo P, Giaquinto C, Rossi P, Palma P, Isaacs M, Cardoso L, Liberty A, Estevao L, Tagarro A, Ndung’u T for EPIICAL

Presented at: CROI 2024

Authors: Tagarro A, Fernández-Luis S, Dominguez-Rodriguez S, Ballesteros A, Kuhn L, Cotton FM, Giaquinto C, Rossi P, Spyer M, Otwombe K, Behuhuma O, Vaz P, Foster C, Rojo P, for EPIICAL

Presented at: CROI 2024

Authors: Delaney EK, Kearney FM, Bester AP, Coetzee N, Engelbrecht S, Giaquinto C, Rossi P, Barnabas LS, Spyer JM, Litcherfeld M, Tagarro A, Lombard C, Cotton FM, Zyl vUG and EPIICAL Consortium

Presented at: CROI 2024

Authors: Fernández-Luis S, Dominguez-Rodriguez S, Kuhn L, Cotton M, Giaquinto C, Rossi P, Rensburg JVA, Violari A, Lain GM, Lopez-Varela E, Sylla M, Amugue P, Rojo P, Tagarro A for EPIICAL Consortium

Presented at: CROI 2024

Authors: Schröter J & De Boer R

Published in: Journal of Theoretical Biology 2023

Authors: Fernández-Luis S, Lain MG, Serna-Pascual M, Domínguez-Rodríguez S, Kuhn L, Liberty A, Barnabas S, Lopez-Varela E, Otwombe K, Danaviah S, Nastouli E, Palma P, Cotugno N, Spyer M, Giannuzzi V, Giaquinto C, Violari A, Cotton MF, Nhampossa T, Klein N, Ramsagar N, van Rensburg AJ, Behuhuma O, Vaz P, Maiga AI, Oletto A, Naniche D, Rossi P, Rojo P, Tagarro A; EPIICAL Consortium

Published in: BioMed Central

Authors: Ruggiero A, Pascucci GR, Cotugno N, Domínguez-Rodríguez S, Rinaldi S, Tagarro A, Rojo P, Foster C, Bamford A, De Rossi A, Nastouli E, Klein N, Morrocchi E, Fatou B, Smolen KK, Ozonoff A, Di Pastena M, Luzuriaga K, Steen H, Giaquinto C, Goulder P, Rossi P, Levy O, Pahwa S, Palma P; EPIICAL Consortium

Published in: Frontiers

Authors: Domínguez-Rodríguez S, Serna-Pascual M, Oletto A, Barnabas S, Zuidewind P, Dobbels E, Danaviah S, Behuhuma O, Lain MG, Vaz P, Fernández-Luis S, Nhampossa T, Lopez-Varela E, Otwombe K, Liberty A, Violari A, Maiga AI, Rossi P, Giaquinto C, Kuhn L, Rojo P, Tagarro A; EPIICAL Consortium

Published in: Plos One

Authors: Domínguez-Rodríguez S, Tagarro A, Foster C, Palma P, Cotugno N, Zicari S, Ruggiero A, de Rossi A, Dalzini A, Pahwa S, Rinaldi S, Nastouli E, Marcelin AG, Dorgham K, Sauce D, Gartner K, Rossi P, Giaquinto C, Rojo P

Published in: Frontiers

Speaker: Morrocchi E

Presented at: CROI 2023

Authors: Bréhin,  Tagarro A,  Domínguez-Rodríguez S,  Kuhn L,  Nhampossa T,  Otwombe K,  Janse van Rensburg A,  Klein N,  Lain MN,  Maiga AI,  Giaquinto C,  Rossi P, Rojo P, EPIICAL Consortium

Presented at: AIDS 2022

Authors: Dominguez Rodriguez S, Ballesteros Á, Kuhn L, Nhampossa T, Otwombe K, Shaun Barnabas S,  Klein N, Lain M.G, Giaquinto C,  Rossi P, Rojo P, Tagarro A, EPIICAL Consortium

Presented at: AIDS 2022

Authors: Sinead E. Morris, Renate Strehlau, Stephanie Shiau, Elaine J. Abrams, Caroline T. Tiemessen, Louise Kuhn, Andrew J. Yates on behalf of the EPIICAL consortium and LEOPARD study teams

Published in: Plos Pathogens

Authors: Irene C, Elba M, Jiménez JL, Mellado MJ, Muñoz-Fernández MÁ

Published in: AIDS Research and Therapy

Authors: Tarancon-Diez L, Consuegra I, Vazquez-Alejo E, Ramos-Ruiz R, Ramos JT, Navarro ML, Muñoz-Fernández MÁ

Published in: Frontiers in immunology

Authors: Ruggiero A, Pascucci G.R, Cotugno N, Domínguez-Rodríguez S, Rinaldi S, Tagarro A, Rojo P, Foster C, Bamford A, De Rossi A, Nastouli E, Klein N, Morrocchi E, Fatou B, Smolen K.K, Ozonoff A, Di Pastena M, Luzuriaga K, Steen H, Giaquinto C, Goulder P, Rossi P, Levy O, Pahwa S, Palma P, the EPIICAL Consortium

Published in: Frontiers in Immunology 

Authors: S Domínguez-Rodríguez, A Tagarro, C Foster, P Palma, N Cotugno, AD Rossi, A Dalzini, SG. Pahwa, E Nastouli, K Gärtner, AG Marcelin, P Rossi, C Giaquinto, P Rojo

Presented at: CROI 2022

Authors: A Tagarro, S Domínguez-Rodríguez, L Kuhn, T Nhampossa, K Otwombe, AJv Rensburg, N Klein, MG Lain, AI. Maiga, C Brehin, C Giaquinto, P Rossi, P Rojo

Presented at: CROI 2022

Authors: A Dalzini, G Ballin, S Dominguez-Rodriguez, P Rojo , M.R Petrara, C Foster, N Cotugno, A Ruggiero, E Nastouli, N Klein, S Rinaldi, S Pahwa, P Rossi, C Giaquinto, P Palma , A De Rossi1, and on behalf of EPIICAL Consortium

Published in: Journal of the International AIDS Society

Authors: Gärtner K, Byott M, Heaney J, Pagliuzza A, Spyer M.J Frampton D, Rossi A.D, Palmas P, Giaquinto C, Conejo P.R, Foster C,  Rossi P, Klein N, Chomont N, Nastouli E, for the EPIICAL consortium

Presented at: Keystone symposia on molecular and cellular biology

Authors: M Doria, S Zicari, N Cotugno, S Domínguez-Rodríguez, A Ruggiero, GR Pascucci, A Tagarro, PR Conejo, E Nastouli, K Gärtner, M Cameron, B Richardson, Ce Foster, SL Williams, S Rinaldi, AD Rossi, C Giaquinto, P Rossi, S Pahwa, P Palma, for the EPIICAL consortium

Published in: Journal of the International Aids Society

Authors: De Rossi A, Dalzini A, Ballin G, Dominguez-Rodriuguez S, Rojo P, Foster C, Palma P, Sessa L, Nastouli E, Pahwa S, Rossi P, Giaquinto C, EPIICAL Consortium

Published in: 23rd International AIDS Conference, July 6th-10th, 2020

Authors: Ruggiero A, Cotugno N, Domínguez-Rodríguez S,  Zicari S, Rinaldi S, Zangari P, Tagarro A, Foster C, De Rossi A, Nastouli E, Luzuriaga K, Giaquinto C, Rossi P, Pawha S, Palma P, on behalf of the EPIICAL consortium.

Published in: 23rd Virtual International AIDS Conference, July 6th-10th, 2020

Authors: Domínguez-Rodríguez S, Tagarro A, Serna Pascual M, Otwombe K, Violari A, Fernández S, Nhampossa T, Lain M,  Vaz P , Behuhuma NO, Danaviah S, Dobbels E, Barnabas S, Cotugno N, Zangari P, Palma P, Oletto A,  Nardone A, Nastouli E, Spyer M, Kuhn L, Rossi P, Giaquinto C, Rojo P on behalf of EPIICAL consortium.

Published in: 23rd international AIDS Conference, July 6th-10th 2020

Authors: Palma P, McManus M, Cotugno N, Rocca S, Rossi P, Luzuriaga K

Published in: Lancet HIV. 2020;7(5):e359-e365

Authors: Dhummakupt A, Rubens JH, Andeson T, et al.

Published in: JCI Insight. 2020;5(4)

Authors: Brice J, Sylla M, Desire N, Sayon S, Telly F, Bocar-Fofana D, Murphy R, Peytavin G, Diallo S, Nastouli E, Calvez V, Marcelin AG, Maiga AI, Lambert-Niclot S

Published in: The Journal of antimicrobial chemotherapy

Authors: Dhummakupt A, Reubens JH, Anderson T, et al.

Published: Poster presented at 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.

Authors: Schröter J, Anelone A,  Yates A, de Boer RJ;  on behalf of the EPIICAL Consortium

Published in: J Acquir Immune Defic Syndr. 2020;83(5):522-529

Background Interventions aiming for an HIV cure would benefit from rapid elimination of virus after the onset of antiretroviral therapy (ART), by keeping the latent HIV reservoir small.

Setting We investigated HIV suppression in 312 perinatally infected infants starting ART within 6 months after birth from the EPPICC (European Pregnancy and Paediatric HIV Cohort Collaboration).

Methods To better understand kinetic differences in HIV suppression among infants, we investigated their individual viral load (VL) decay dynamics. We identified VL decay patterns and determined times to viral suppression (TTS). For infants with strictly declining VLs (n = 188), we used parameter fitting methods to estimate baseline VLs, decay rates, and TTS. We subsequently identified the parameters determining TTS by linear modeling.

Results The majority of infants suppress HIV VL after the onset of ART. Some children experienced a long TTS due to an “erratic” VL decay pattern. We cannot exclude that this is partly due to treatment complications and subsequent treatment changes, but these children were characterized by significantly lower CD4 percentages (CD4%) at start of treatment compared with those with a “clean” VL decline. Focusing on this “clean” subset, the TTS could be predicted by mathematical modeling, and we identified baseline VL and CD4% as the major factors determining the TTS.

Conclusions As VL steeply increases and CD4% constantly decreases in untreated HIV-infected infants, the progression of an HIV infection is largely determined by these 2 factors. To prevent a further disease progression, treatment should be initiated early after contracting HIV, which consequently shortens TTS.

Authors: Dominguez-Rodriguez S, Rojo P, Lain MG,  Barnabas S, Lopez-Varela E, Otwombe K, Danaviah S, Nastouli E, Serna-Pasqual M, Gianuzzi V, Giaquointo C, Kuhn L, Tagarro A on behalf of the EPIICAL Consortium

Published in: 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.

Authors: Zicari S, Doria M, Domínguez-Rodríguez S, Cotugno N, Tagarro A, Rojo P, Nastouli E, Gartner K, Klein N, Foster C, Pahwa S, De Rossi A, Giaquinto C, Rossi P,  Palma P, for the EPIICAL consortium

Published in: 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.

Authors: Tagarro A, Domínguez-Rodríguez S, Violari A, Cotton M, Mhampossa T, Klein N, Ramsagar N, Van Rensburg AJ, Behuhuma O, Vaz P,  Oletto A, Palma P, Rossi P, Rojo P, on behalf of the EPIICAL Consortium

Published in:  27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.

Authors: Gärtner K, Gkouleli T, Byott M, Heaney J, Spyer MJ, DeRossi A, Persaud D, Palma P, Giaquinto C, Rojo P, Foster C, Marcelin AG, Rossi P, Nastouli E, for the EPIICAL consortium

Published in:  27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.

Authors: Gärtner K, Gkouleli T, Heaney J, Grant P, Dominguez-Rodriguez S, Busby E, O’Sullivan D, Spyer MJ, Foster C, Rojo P, Persaud D, DeRossi A, Huggett J, Nastouli E, for the EPIICAL consortium

Published in:  27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.

Authors: Rinaldi S, Pallikkuth S, de Armas L, Pahwa R, Dominguez S, Cotugno N, Rojo Conejo P, Nastouli E, Gartner K, Klein N, Foster C, De Rossi A, Carlo Giaquinto C, Rossi P, Palma P, Pahwa S and EPIICAL Consortium

Published in:  27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.

Authors: Lain MG, Vaz P, Ismael N,  Cantarutti A, Porcu G, Palma P, Cotugno N, Bila D, Rinaldi S,  Pallikkuth S, Pahwa R, Taibo E, Esmeralda Karajeanes E, Giaquinto C, Pahwa S.

Published in:  27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.

Authors: Morris SE, Dziobek-Garrett L, Yates AJ and the EPIICAL consortium

Published in: BMC Bioinformatics 2020;21(1):52

Background HIV/AIDS is responsible for the deaths of one million people every year. Although mathematical modeling has provided many insights into the dynamics of HIV infection, there is still a lack of accessible tools for researchers unfamiliar with modeling techniques to apply them to their own clinical data.