
23
Mar, 2022
Borrowing information across patient subgroups in clinical trials
An article by investigators within the ODYSSEY trial has been published as Open Access into BMC Medical Research Methodology. The investigators aimed to evaluate a treatment effect in a pre-defined subgroup of interest while borrowing information from a separate patient subgroup, using a Bayesian analysis. A Bayesian analysis enables evidence from data to be combined with prior information from an external sample. Phase III clinical trials demonstrate whether or not medical intervention is effective and safe in a specific population. For various reasons, investigators may choose to evaluate effectiveness and safety […]