1999
Authors: Paediatric European Network for Treatment of AIDS (PENTA)
Published in: HIV Med. 1999;1(1):25-31
Objective The study aimed to explore the experience of parents/care-givers to their child’s participation in a European randomized trial of immediate (zidovudine) with deferred (placebo) antiretroviral treatment in asymptomatic children with vertically acquired HIV infection (PENTA 1 trial).
Design One hundred and thirty-three questionnaires were distributed to parents/care-givers (68% of children in the trial) through their paediatrician prior to unblinding the individual child’s therapy (zidovudine/placebo) and 84 (63% response rate) were returned.
1998
Authors: Paediatric European Network for Treatment of AIDS (PENTA)
Published in: AIDS. 1998;12(4):F1-8
Background Plasma HIV-1 RNA levels are high in vertically infected infants. Information in older children is limited, particularly in those who have not received antiretroviral therapy.
Objectives To describe the relationships between HIV-1 RNA, age and CD4 cell count in untreated vertically infected children.