HIV

Analytical treatment interruption in children living with HIV: position statement from the EPIICAL consortium

2024

Authors: Kuhn L, Barnabas S, Cotugno N, Peay H, Goulder P, Cotton M, Violari A, Pahwa S, Reddy K, Tagarro A, Otwombe K, Fry S, Vaz P,

Effectiveness and Safety of Dolutegravir in Children and Adolescents Living With HIV in Europe and Thailand

2024

Authors: Scott K, O’Rourke J, Crichton S, Chappell E, Ene L, Galli L, Goetghebuer T, Henegar C, Hoffmann UT, Königs C, Marczyńska M, Naver L, Noguera-Julian A,

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Viral failure in children and adolescents living with HIV on dolutegravir (DTG) in Europe and Thailand

2024

Authors: Scott K, Crichton S, Jackson C, Ene L, Galli L, Goetghebuer T, Henegar C, Königs C, Marczyńska M, Naver L, Noguera-Julian A, Paioni P, Puthanakit T, Ramos TJ, Smith B,

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D3/Penta 21 clinical trial design: A randomised non-inferiority trial with nested drug licensing substudy to assess dolutegravir and lamivudine fixed dose formulations for the maintenance of virological suppression in children with HIV-1 infection, aged 2 to 15 years

2024

Authors: Turkova A, Chan MK, Kityo C, Kekitiinwa AR, Musoke P, Violari A, Variava E, Archary M, Cressey TR, Chalermpantmetagul S, Sawasdichai K, Ounchanum P, Kanjanavanit S,

HIV-1 drug resistance dynamics in the EARTH cohort: a mother-infant pair perspective

2024

Authors: Torres-Fernandez D, Domínguez-Rodríguez S, Fernández-Luis S, Nhampossa T, Lopez-Varela E, Naniche D, Lain GM, Ismael N, Spyer JM, Byott M, Nastouli E, Rossi P, Rojo P, Tagarro A on behalf of the EPIICAL Consortium.

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HIV-1 drug resistance dynamics in the EARTH cohort: a mother-infant pair perspective

2024

Authors: Torres-Fernandez D, Domínguez-Rodríguez S, Fernández-Luis S, Nhampossa T, Lopez-Varela E, Naniche D, Lain GM, Ismael N, Spyer JM, Byott M, Nastouli E, Rossi P, Rojo P, Tagarro A on behalf of the EPIICAL Consortium.

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High mortality following early initiation of antiretroviral therapy in infants living with HIV from three African countries

2024

Authors: Tagarro A, Domínguez-Rodríguez S, Cotton M, Otwombe K, Klein N, Lain GM, Nhampossa T, Maiga IA, Barnabas S, Vaz P, Violari A, Fernández-Luis S, Behuhuma O,

Pharmacokinetics of once-daily DTG/3TC FDC in children living with HIV: D3/PENTA21 sub-study

2024

Authors: Bevers HAL, Chan KM, Bbuye D, Kekitiinwa RA, Kityo C, Kaudha E, Ahimbisibwe MG, Arumugam T, Moloantoa T, Boles J, Deprez I, Giaquinto C, Turkova A, Colbers A for the D3/Penta21 trial team

Presented at: CROI 2024

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HIV-1 Reservoir Dynamics in Children With Early Treated, Perinatally-Acquired HIV: Does Sex Matter?

2024

Authors: Reddy K, Molechan C, Dominguez-Rodriguez S, Smith T, Spyer M, Lichterfeld M, Rojo P, Giaquinto C, Rossi P, Palma P, Isaacs M, Cardoso L, Liberty A, Estevao L,

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Outcomes Following Prenatal Exposure to Raltegravir: A Multi-Cohort European Study

2024

Authors: Sconza R, Fernandes G, Aebi-Popp K, Ene L, Frick A, Gamell A, Ramos IM, Kahlert C, Peters H, Tato PML, Samarina A, Giaquinto C, Thorne C for the EPPICC Pregnancy Study Group

Presented at: CROI 2024

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ODYSSEY 192-week follow-up evidences superior efficacy of DTG for children on first/second-line ART

2024

Authors: Mujuru AH, White E, Kekitiinwa A, Lugemwa A, Kityo C, Musoke P, Cressey RT, Variava E, Violari A, Archery M, Cotton M, Puthanakit T, Rojo P, Turkova A

Presented at: CROI 2024

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Causes of death after early ART in infants living with HIV from 3 sub-Saharan African countries

2024

Authors: Tagarro A, Fernández-Luis S, Dominguez-Rodriguez S, Ballesteros A, Kuhn L, Cotton FM, Giaquinto C, Rossi P, Spyer M, Otwombe K, Behuhuma O, Vaz P, Foster C, Rojo P,

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An efficient envelope genotypic assay to identify bNab susceptibility in infants with HIV

2024

Authors: Delaney EK, Kearney FM, Bester AP, Coetzee N, Engelbrecht S, Giaquinto C, Rossi P, Barnabas LS, Spyer JM, Litcherfeld M, Tagarro A, Lombard C, Cotton FM, Zyl vUG and EPIICAL Consortium

Presented at: CROI 2024

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1 in 5 sub-Saharan infants switches from undetectable to detectable HIV viral load during follow-up  

2024

Authors: Fernández-Luis S, Dominguez-Rodriguez S, Kuhn L, Cotton M, Giaquinto C, Rossi P, Rensburg JVA, Violari A, Lain GM, Lopez-Varela E, Sylla M, Amugue P, Rojo P, Tagarro A for EPIICAL Consortium

Presented at: CROI 2024

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Major revision version 12.0 of the European AIDS Clinical Society guidelines 2023

2024

Authors: Ambrosioni J, Levi L, Alagaratnam J, Van Bremen K, Mastrangelo A, Waalewijn H, Molina JM, Guaraldi G, Winston A, Boesecke C, Cinque P, Bamford A, Calmy A,

Simultaneous pharmacokinetic modeling of unbound and total darunavir with ritonavir in adolescents: a substudy of the SMILE trial

2023

Authors: Abdalla S, Compagnucci A, Riault Y, Chan KM, Bamford A, Nolan A, Ramos TJ, Constant V, Nguyen T, Zheng Y, Tréluyer J, Froelicher-Bournaud L, Neveux N, Saidi Y,

Pregnancy and neonatal outcomes following prenatal exposure to dolutegravir: the DOLOMITE EPPICC study

2023

Authors: Thorne C, Aebi-Popp K, Ene L, Floridia M, Gamell A, Illan M, Peters H, Samarina A, Fernandes G, Sconza R, Ragone L, Giaquinto C, Vannappagari V

Presented at: EACS 2023

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What explains the poor contraction of the viral load during paediatric HIV infection?

2023

Authors: Schröter J & De Boer R

Published in: Journal of Theoretical Biology 2023

Effect of dolutegravir on folate, vitamin B12 and mean corpuscular volume levels among children and adolescents with HIV: a sub-study of the ODYSSEY randomized controlled trial 

2023

Authors: Barlow-Mosha L.N., Ahimbisibwe G.M., Chappell E., Amuge P.M., Nanduudu A., Kaudha E., Amukele T., Balamusani D., Kafufu B., Nimwesiga A., Kataike H., Namwanje R., Kasangaki G., Mulindwa A.,

Novel Approaches to Postnatal Prophylaxis to Eliminate Vertical Transmission of HIV

2023

Authors: Ruel T, Penazzato M, Zech JM, Archary M, Cressey TR, Goga A, Harwell J, Landovitz RJ, Lain MG, Lallemant M, Namusoke-Magongo E, Mukui I, Permar SR, Prendergast AJ,

The Smooth Away From Expected (SAFE) non-inferiority frontier: theory and implementation with an application to the D3 trial

2023

Authors: Quartagno, M, Chan, M, Turkova, A et al.

Published in: Trials

Sensitive HIV-1 DNA Pol Next-Generation Sequencing for the Characterisation of Archived Antiretroviral Drug Resistance

2023

Authors: Botha JC, Byott M, Spyer MJ, Grant PR, Gärtner K, Chen WX, Burton J, Bamford A, Waters LJ, Giaquinto C, et al.

Published in: Viruses

Virological suppression and weight gain in children in Europe on dolutegravir compared to protease inhibitors: a propensity score analysis 

2023

Presented by: Siobhan Crichton 

Presented at: International Workshop on HIV and Pediatrics

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Uptake of integrase inhibitors and virological response in children living with HIV in Europe & Thailand from 2010 to 2020  

2023

Presented by: Jeannie Collins

Presented at: IAS and International Workshop on HIV and Pediatrics

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Uptake and outcomes of tenofovir alafenamide fumarate (TAF) –based therapy in children and young people living with HIV (CLWHIV) in the European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC)

2023

Presented by: Siobhan Crichton

Presented at: IAS and International Workshop on HIV and Pediatrics

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Impact of COVID-19 pandemic on HIV viral load testing in paediatric HIV clinics in the European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC)  

2023

Presented by: Siobhan Crichton

Presented at: IAS and International Workshop on HIV and Pediatrics

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Incidence and severity of SARS-CoV-2 infection in children and young people with HIV in Europe

2023

Authors: Chappell E, Bamford A, Sanchez AB, Goetghebuer T, Marques L, Navér L, Noguera-Julian A, Talarek E, Plotnikova Y, Samarina A, Ene L, Spoulou V, Collins IJ,

Nucleoside/nucleotide reverse transcriptase inhibitor sparing regimen with once daily integrase inhibitor plus boosted darunavir is non-inferior to standard of care in virologically-suppressed children and adolescents living with HIV – Week 48 results of the randomised SMILE Penta-17-ANRS 152 clinical trial

2023

Authors: Compagnucci A, Chan KM, Saïdi Y, Cressey RT, Bamford A, Riault Y, Coelho A, Nolan A, Chalermpantmetagul S, Morkunaite G, Amuge P, Musiime V, Violari V, Cotton M,

Optimizing the World Health Organization algorithm for HIV vertical transmission risk assessment by adding maternal self-reported antiretroviral therapy adherence

2023

Authors: Fernández-Luis S, Lain MG, Serna-Pascual M, Domínguez-Rodríguez S, Kuhn L, Liberty A, Barnabas S, Lopez-Varela E, Otwombe K, Danaviah S, Nastouli E, Palma P, Cotugno N, Spyer M,

Determinants of B-Cell Compartment Hyperactivation in European Adolescents Living With Perinatally Acquired HIV-1 After Over 10 Years of Suppressive Therapy

2023

Authors: Ruggiero A, Pascucci GR, Cotugno N, Domínguez-Rodríguez S, Rinaldi S, Tagarro A, Rojo P, Foster C, Bamford A, De Rossi A, Nastouli E, Klein N, Morrocchi E,

Machine learning outperformed logistic regression classification even with limit sample size: A model to predict pediatric HIV mortality and clinical progression to AIDS

2023

Authors: Domínguez-Rodríguez S, Serna-Pascual M, Oletto A, Barnabas S, Zuidewind P, Dobbels E, Danaviah S, Behuhuma O, Lain MG, Vaz P, Fernández-Luis S, Nhampossa T, Lopez-Varela E, Otwombe K,

Clinical, Virological and Immunological Subphenotypes in a Cohort of Early Treated HIV-Infected Children

2023

Authors: Domínguez-Rodríguez S, Tagarro A, Foster C, Palma P, Cotugno N, Zicari S, Ruggiero A, de Rossi A, Dalzini A, Pahwa S, Rinaldi S, Nastouli E, Marcelin AG,

Mortality linked to higher inflammation in kids with perinatal HIV

2023

Speaker: Morrocchi E

Presented at: CROI 2023

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SARS-COV-2 in children & adolescents living with HIV in Europe & South Africa

2023

Authors: Jackson C, Crichton S, Bamford A, Berzosa A, Gilmour K, Goetghebuer T,  Johnson SM, Judd A, Noguera-Julian A, Le Prevost M, Spoulou V, Sturgeon K,  VolokhamA, Zar HJ,

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Outcomes of etravirine-based antiretroviral treatment in treatment-experienced children and adolescents living with HIV in Europe and Thailand

2022

Authors: European Pregnancy And Paediatric Infections Cohort Collaboration Eppicc, Lyons A, Thompson L, Chappell E, Ene L, Galli L, Goetghebuer T, Jourdain G, Noguera-Julian A, Kahlert CR, Königs C,

Once-daily dolutegravir-based antiretroviral therapy in infants and children living with HIV from age 4 weeks: results from the below 14 kg cohort in the randomised ODYSSEY trial

2022

Authors: Amuge P, Lugemwa A, Wynne B, Mujuru AH, Violari A, Kityo MC, Archary M, Variava E, White E, Turner MR, Shakeshaft C, Ali S, Nathoo JK, Atwine L,

Probability of AIDS and non-AIDS-related mortality of early-treated children living with HIV-1

2022

Authors: Bréhin,  Tagarro A,  Domínguez-Rodríguez S,  Kuhn L,  Nhampossa T,  Otwombe K,  Janse van Rensburg A,  Klein N,  Lain MN,  Maiga AI,  Giaquinto C,  Rossi P, Rojo P,

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Joint evolution of CD4 and viral load trajectories over 2 years in an early-treated pediatric African cohort

2022

Authors: Dominguez Rodriguez S, Ballesteros Á, Kuhn L, Nhampossa T, Otwombe K, Shaun Barnabas S,  Klein N, Lain M.G, Giaquinto C,  Rossi P, Rojo P, Tagarro A, EPIICAL Consortium

Presented at: AIDS 2022

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Healthy dynamics of CD4 T cells may drive HIV resurgence in perinatally-infected infants on antiretroviral therapy

2022

Authors: Sinead E. Morris, Renate Strehlau, Stephanie Shiau, Elaine J. Abrams, Caroline T. Tiemessen, Louise Kuhn, Andrew J. Yates on behalf of the EPIICAL consortium and LEOPARD study teams

Published in: Plos Pathogens

Incidence of SARS-CoV-2 infection and clinical characteristics in children and young people living with HIV in Europe

2022

Authors: Chappell E, Bamford A, Berzosa Sanchez A, Goetghebuer T, Marques L, Naver L, NogueraJulian A, Talarek E, Plotnikova Y, Samarina A, Ene L, Spolou V, Collins I

Presented at: International Workshop on HIV & Pediatrics 2022

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Population pharmacokinetics of unbound and total plasma dolutegravir concentrations in children ≥ 12 years old: A pharmacokinetic sub-study of the SMILE trial-PENTA17-ANRS 152

2022

Authors: Abdalla S, Compagnucci A, Riault Y, Cressey T, Saidi Y, Chan M, Coelho A, Nolan A, Chalermpantmetagul S, Amuge P, Musiime V, Violari A, Cotton M, Volokha A,

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Voluntary Consent to Research on HIV-infected Children in the CHAPAS-4 and ODYSSEY HIV Clinical Trials

2022

Authors: Makumbi S, Bajunirwe F, Ford D, Turkova A, Lugemwa A, Musiime V, Gibb D, Tamwesigire K.I

Presented at: International Workshop on HIV & Pediatrics 2022

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What babies need: accelerating access to current and novel antiretroviral drugs in neonates through pharmacokinetic studies

2022

Authors:Jacobs TG, Schouwenburg S, Penazzato M, Archary M, Ruel TD, van den Anker J, Burger DM, Cressey TR, Abrams EJ, Lyall H, Bekker A, Colbers A; Penta Clinical Pharmacology Working Group;

Dolutegravir twice-daily dosing in children with HIV-associated tuberculosis: a pharmacokinetic and safety study within the open-label, multicentre, randomised, non-inferiority ODYSSEY trial

2022

Authors: Turkova A, Waalewijn H, Chan M, Bollen P, Bwakura-Dangarembizi M, Kekitiinwa A, Cotton M, Lugemwa A, Variava E, Ahimbisibwe MG, Srirompotong U, Mumbiro V,Amuge P, Zuidewind P,

HIV HGM biobank as a research platform for paediatric infectious diseases and COVID-19 pandemic

2022

Authors: Irene C, Elba M, Jiménez JL, Mellado MJ, Muñoz-Fernández MÁ

Published in: AIDS Research and Therapy

miRNA Profile Based on ART Delay in Vertically Infected HIV-1 Youths Is Associated With Inflammatory Biomarkers and Activation and Maturation Immune Levels

2022

Authors: Tarancon-Diez L, Consuegra I, Vazquez-Alejo E, Ramos-Ruiz R, Ramos JT, Navarro ML, Muñoz-Fernández MÁ

Published in: Frontiers in immunology

Determinants of B-Cell Compartment Hyperactivation in European Adolescents Living With Perinatally Acquired HIV-1 After Over 10 Years of Suppressive Therapy

2022

Authors: Ruggiero A, Pascucci G.R, Cotugno N, Domínguez-Rodríguez S, Rinaldi S, Tagarro A, Rojo P, Foster C, Bamford A, De Rossi A, Nastouli E, Klein N, Morrocchi E,

The subphenotypes of early-treated children living with HIV-1

2022

Authors: S Domínguez-Rodríguez, A Tagarro, C Foster, P Palma, N Cotugno, AD Rossi, A Dalzini, SG. Pahwa, E Nastouli, K Gärtner, AG Marcelin, P Rossi, C Giaquinto, P Rojo

Presented at: CROI 2022

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2-year outcome of early treated infants in Sub-Saharan Africa

2022

Authors: A Tagarro, S Domínguez-Rodríguez, L Kuhn, T Nhampossa, K Otwombe, AJv Rensburg, N Klein, MG Lain, AI. Maiga, C Brehin, C Giaquinto, P Rossi, P Rojo

Presented at: CROI 2022

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Birth outcomes following prenatal exposure to dolutegravir: the DOLOMITE-EPPICC study

2022

Authors: C Thorne, K Aebi-Popp, L Ene, M Floridia, AM Gamell, M Illan, H Peters, A Samarina, L Ragone, C Giaquinto, V Vannappagari

Presented at: CROI 2022

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