Authors: Folgori L, Lutsar I, Standing JF, et al.
Published in: BMJ Open. 2019; 9:e032592
Authors: Blazquez-Gamero D, Soriano-Ramos M, Martinez de Aragon A, et al.
Published in: Pediatr Infect Dis J. 2019;38(11):1131-1137
Authors: Tedder RS, Dicks S, Ijaz S, et al.
Published in: PLoS One. 2019;14(8):e0215708
Abstract: The accurate diagnosis and seroprevalence investigations of Zika virus (ZKV) infections remain complex due to cross reactivity with other flaviviruses. Two assay formats, both using labelled Zika virus NS1 antigen as a revealing agent (a double antigen binding assay,
Authors: Turner B, Ford D, Moore C, Gibb D, Turkova A, White I, and ODYSSEY trial team
Published in: Oral Presentation atInternational Society for Clinical Biostatics; July 16th 2019
Authors: Giovannetti M, de Mendonca MCL, Fonseca V, et al.
Published in: J Virol. 2019;94(1). pii: e01623-19
Abstract The recent reemergence of yellow fever virus (YFV) in Brazil has raised serious concerns due to the rapid dissemination of the virus in the southeastern region. To better understand YFV genetic diversity and dynamics during the recent outbreak in southeastern Brazil,
Authors: Goncalves BS, Nogueira RMR, Bispo de Filippis AM, Horta MAP
Published in: Trans R Soc Trop Med Hyg. 2019;113(11):670-677
Authors: Domínguez-Rodríguez S, Tagarro A. Palma P, et al.
Published in: JAIDS 2019;82(5):483-490
Authors: Schröter J.
Published in: Poster presented at 4th Workshop on Virus Dynamics, October 21st-23rd, 2019 -Paris, FR
Authors: Li G, Bielicki JA, Ahmed ASMNU, et al.
Published in: Arch Dis Child.2091;0:1-6
Authors:Simitsopoulou M, Kadiltzoglou P, Kyrpitzi D, Roilides E.
Published in: Int J Biol Med Res.2019;10(1):6591-6596
Abstract This study aimed to compare the effects of vancomycin, linezolid and daptomycin against planktonic cells and biofilms of 32 bloodstream isolates derived from neonates and adults of three hospitals. Staphylococcus epidermidis biofilm formation was spectrophotometrically assessed following safranin staining.
Authors: Jacqz-Aigrain E, Leroux S, Thomson AH, et al.
Published in: J Antimicrob Ther 2019; 74(8):2128-2138
Authors: Torres MC, de Bruycker Nogueira F, Fernandes CA, et al.
Published in: PLoS One. 2019;14(12):e0225879
Abstract The Asian/American genotype of dengue virus serotype 2 (DENV-2) has been introduced in Brazil through the state of Rio de Janeiro around 1990, and since then it has been spreading and evolving, leading to several waves of dengue epidemics throughout the country that cause a major public health problem.
Authors: Brenes-Chacón H, Ávila-Agüero ML, Camacho-Badilla K, Naranjo-Zuñiga G, Benavides-Lara A, Soriano-Fallas A
Published in: ID Week, Washington DC, October 2nd – 6th 2019
Authors: Gärtner K, Gkouleli T, Heaney J, et al; on behalf of the EPIICAL consortium
Published: Poster presented at HIV Cure and Reservoir Symposium, September, 16th-20th, 2019 -Ghent, BE
Authors: Schwarz ER, Pozor MA, Pu R, et al.
Published in: Viruses. 2019;11(9)
Abstract Zika virus (ZIKV) is a vertically and sexually transmissible virus resulting in severe congenital malformation. The goal of this study was to develop an ovine model of ZIKV infection. Between 28–35 days gestation (DG), four pregnant animals were infected with two doses of 6 × 106 PFU of ZIKV;
Authors: Sulleiro E, Rando A, Alejo I, et al.
Published in: Clin Microbiol Infect. 2019;25(5):633.e5-633.e9
Objectives The aim was to describe pregnancy outcomes after Zika virus (ZIKV) infection in a non-endemic region.
Methods According to the Spanish protocol issued after the ZIKV outbreak in Brazil in 2015, all pregnant women who had travelled to high-burden countries were screened for ZIKV.
Authors: Sulleiro E, Rando A, Alejo I, et al.
Published in: Travel Med Infect Dis. 2019;29:69-71
No abstract available
Authors: Siqueira Mello A, Pascalicchio Bertozzi APA, Rodrigues MMD, et al.
Published in: Am J Case Rep. 2019 May 21;20:723-725
Background The Zika virus is an arbovirus that has as main source of transmission the bite of infected insects of the genus Aedes and has been associated with cases of congenital malformation and microcephaly in neonates.
Authors: Vedovello D, Witkin SS, Silva ACB, et al.
Published in: J Neurovirol 2019 Sep 9. doi: 10.1007/s13365-019-00797-0
Abstract Paired maternal and newborn urine and amniotic fluid from 138 subjects collected during a Zika virus (ZIKV) outbreak was analyzed for ZIKV by gene amplification (RT-qPCR), and the findings were correlated with clinical symptoms and neurological anomalies in the babies.
Authors: Sulleiro E, Frick MA, Rodó C, et al.
Published in: Medicine (Baltimore). 2019;98(20):e15532
Introduction Zika virus (ZIKV) has caused one of the most challenging global infectious epidemics in recent years because of its causal association with severe microcephaly and other congenital malformations. The diagnosis of viral infections usually relies on the detection of virus proteins or genetic material in clinical samples as well as on the infected host immune responses.
Authors: Kaguelidou F, Le Roux E, Mangiarini L, et al.; GAPP consortium
Published in: BMJ Open. 2019;9(2):e023296
Introduction Gabapentin is currently used ‘off-label’ in children and adolescents with chronic neuropathic pain, and reliable evidence of its effects and optimal dosing are lacking.
Objectives The GABA-1 trial aims to compare the efficacy and safety of gabapentin liquid formulation relative to tramadol and to explore the pharmacokinetics of both drugs in the treatment of chronic,
Authors: de Leeuw TG, Mangiarini L, Lundin R, et al; GAPP consortium
Published in: Trials. 2019; 20(1):368
Background Gabapentin has shown efficacy in the treatment of chronic neuropathic or mixed pain in adults. Although pediatric pain specialists have extensive experience with gabapentin for the treatment of neuropathic pain, its use is off-label. Its efficacy and safety in this context have never been shown.
Authors: Waalewijn H, Bollen PDJ, Moore C, Kekitiinwa A, et al. The ODYSSEY Trail Team
Published in: Oral Presentation at 10th IAS Conference, July, 21-24th 2019
Authors: Tedder RS, Dicks S, Ijaz S, et al.
Published in: PLoS One. 2019;14(8):e0215708
Abstract The accurate diagnosis and seroprevalence investigations of Zika virus (ZKV) infections remain complex due to cross reactivity with other flaviviruses. Two assay formats, both using labelled Zika virus NS1 antigen as a revealing agent (a double antigen binding assay,
Authors: Kraemer MUG, Reiner RC Jr, Brady OJ, et al.
Published in: Nat Microbiol. 2019;4:900
Abstract The global population at risk from mosquito-borne diseases—including dengue, yellow fever, chikungunya and Zika—is expanding in concert with changes in the distribution of two key vectors: Aedes aegypti and Aedes albopictus. The distribution of these species is largely driven by both human movement and the presence of suitable climate.
Authors: Foster C, Dominguez S, Tagarro A, Nastouli E, Gkouleli R, Heaney J, PalmaP, Rossi P, Giaquinto C, Rojo P
Published: 10th IAS Conference on HIV Science, July 21rd-24th 2019, Mexico City
Background Future strategies aimed at achieving antiretroviral therapy (ART)-free HIV remission are likely to target individuals with a limited size of viral reservoir.
Authors: Heaney J, Busby E, Gärtner K, Grant P, Spyer MJ, O’Sullivan DM, Gkouleli T, Marcelin AG, Pillay D, Foster C, Rojo P, Palma P, Muñoz Fernández MA, deRossi A, Huggett JF, Nastouli E
Published: International Workshop on HIV Pediatrics, July 19th-20th, 2019. P_102
Background Despite effective antiretroviral therapy(ART), HIV persists as integrated provirus generating latent viral reservoirs even in the absence of detectable plasma viremia.
Authors: Wilder-Smith A, Wei Y, Araújo TVB et al;Zika Virus Individual Participant Data Consortium
Published in: BMJ Open. 2019;9(6):e026092. doi: 10.1136/bmjopen-2018-026092.
Introduction Zika virus (ZIKV) infection during pregnancy is a known cause of microcephaly and other congenital and developmental anomalies. In the absence of a ZIKV vaccine or prophylactics, principal investigators (PIs) and international leaders in ZIKV research have formed the ZIKV Individual Participant Data (IPD) Consortium to identify,
Authors: Colbers A, Bollen P, Freriksen J, Konopnicki D, Weizsäcker K, Hidalgo Tenorio C, Moltó J, Taylor G, Alejandre I, van Crevel R, Burger D; on behalf of the PANNA network
Published: 26th Conference on Retroviruses and Opportunistic Infections, March 4th – 7th, 2019– Seattle. P_758.
Authors: Colbers A, Bollen P, Freriksen J, Konopnicki D, Weizsäcker K, Hidalgo Tenorio C, Moltó J, Taylor G, Alejandre I, van Crevel R, Burger D.
Published: Oral presentation at 9th edition of the International Workshop on HIV & Women, March 2nd-3rd 2019, Seattle
Authors: Kreitchmann R, Schalkwijk S, Best B, et al.
Published in: Antivir Ther. 2019;24(2):95-103
Background Limited data exist on efavirenz pharmacokinetics in HIV-positive pregnant women and neonatal washout.
Methods HIV-infected pregnant women receiving 600 mg efavirenz once daily had intensive steady-state 24-h pharmacokinetics profiles during the second trimester (2T),
Authors: Schalkwijk S, Ter Heine R, Colbers A, et al.
Published in: J Antimicrob Chemother. 2019;30 [Epub ahead of print]
Background Darunavir 800 mg once (q24h) or 600 mg twice (q12h) daily combined with low-dose ritonavir is used to treat HIV-positive pregnant women. Decreased total darunavir exposure (17%-50%) has been reported during pregnancy,
Authors: Tagarro A, Dominguez Rodriguez S, Puthanakit T, et al.
Published: Oral presentation at 27th Conference on Retroviruses and Opportunistic Infections, March 4th-7th, 2019 – Seattle, WA
Abstract: Early antiretroviral therapy (ART) in children is associated with better clinical and virological outcome. Few data are available about long-term outcome of children starting ART in the neonatal period.
Authors: Gray ER, Heaney J, Ferns RB, Sequeira PC, Nastouli E, Garson JA
Published in: J Virol Methods. 2019;268:17-23
Abstract Dengue is a vector-transmitted viral infection that is a significant cause of morbidity and mortality in humans worldwide, with over 50 million apparent cases and a fatality rate of 2.5 % of 0.5 million severe cases per annum in recent years.
Authors: Hayashida K, Orba Y, Sequeira PC, et al.
Published in: PLoS Negl Trop Dis. 2019;13(6):e0007480
Abstract Detection and sequencing of chikungunya virus (CHIKV) genome was performed using a combination of a modified reverse transcription loop-mediated isothermal amplification (RT-LAMP) method and a MinION sequencer. We developed the protocol for drying all the reagents for the RT-LAMP in a single reaction tube.
Authors: Hsia Y, Lee BR, Versporten A, et al; GARPEC and Global-PPS networks.
Published in: Lancet Glob Health. 2019;7(7):e861-e871
Background Improving the quality of hospital antibiotic use is a major goal of WHO’s global action plan to combat antimicrobial resistance. The WHO Essential Medicines List Access, Watch, and Reserve (AWaRe) classification could facilitate simple stewardship interventions that are widely applicable globally.
Authors: Balasegaram M, Pécoul B, Gray G, Sharland M, Swaminathan S.
Published in: Lancet Infect Dis. 2019;19(6):573-574
Abstract Newborn babies, infants, and children are substantially affected by antimicrobial resistance. Globally, infectious diseases remain a major cause of morbidity and mortality in children, and an estimated 214 000 newborn babies died from drug-resistant bacterial infections in 2015
Authors: Mavian C, Dulcey M, Munoz O, Salemi M, Vittor AY, Capua I.
Published in: Viruses. 2019; 11(1):11
Abstract During the past ten years, an increasing number of arbovirus outbreaks have affected tropical islands worldwide. We examined the available literature in peer-reviewed journals, from the second half of the 20th century until 2018, with the aim of gathering an overall picture of the emergence of arboviruses in these islands.
Authors: O’Brien S, Sharland M, Zaoutis T
Published in: AMR CONTROL 2019-2020; online edition
Abstract It is time to prioritize children’s needs in the context of antimicrobial resistance (AMR). Children, especially babies and young infants, are particularly vulnerable to the rise in drug-resistant infection and need treatments that are adapted to their specific needs. Yet, there are almost no clinical trials looking into children’s antibiotics.
Authors: Queiroz A,Dantas Pinto IF, Lima M, et al.
Published in: Front Microbiol. 2019;10:753
Abstract Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the Flavivirus genus of the Flaviviridae family. Since the large outbreaks in French Polynesia in 2013-2014 and in Brazil in 2015, ZIKV has been considered a new public health threat.
Authors: Rackow A, Ehmen C, von Possel R, et al.
Published in: Clin Chem. 2019;65(3):451-461.
Background The cellular surface molecule HsTOSO/FAIM3/HsFcμR has been identified as an IgM-specific Fc receptor expressed on lymphocytes. Here, we show that its extracellular immunoglobulin-like domain (HsFcμR-Igl) specifically binds to IgM/antigen immune complexes (ICs) and exploit this property for the development of novel detection systems for IgM antibodies directed against Crimean-Congo hemorrhagic fever virus (CCHFV) and Zika virus (ZIKV).
Authors: Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration.
Published in: Lancet HIV. 2019;6(2):e105-e115.
Background Estimates of incidence of switching to second-line antiretroviral therapy (ART) among children with HIV are necessary to inform the need for paediatric second-line formulations. We aimed to quantify the cumulative incidence of switching to second-line ART among children in an international cohort collaboration.
Authors: European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group in EuroCoord
Published in: HIV Med. 2019;20(5):291-307
Objectives Combination neonatal prophylaxis (CNP) is recommended in high‐risk situations for the prevention of mother‐to‐child HIV transmission, although data on its safety are limited. The aim of the study was to identify whether neonatal prophylaxis (NP) type is associated with the risk of severe anaemia or neutropaenia.
Authors: Collins IJ; European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group in EuroCoord
Published in: Clin Infect Dis. 2019; 28. pii: ciz253. doi: 10.1093/cid/ciz253. [Epub ahead of print]
Background In HIV-positive adults, low CD4 cell counts despite fully suppressed HIV-1 RNA on antiretroviral therapy (ART) have been associated with increased risk of morbidity and mortality.
Authors: Thomas R, Velaphi S, Ellis S, et al.
Published in: Expert Opin Pharmacother. 2019;20(4):415-422.
Introduction The incidence of healthcare-associated multidrug resistant bacterial infections, particularly due to carbapenem resistant organisms, has been on the rise globally. Among these are the carbapenem resistant Acinetobacter baumannii and Enterobacteriaceae, which have been responsible for numerous outbreaks in neonatal units.
Authors: Donà D, Luise D, La Pergola E, et al.
Published in: Antimicrob Resist Infect Control. 2019;8:13.
Purpose This study aims to determine the effectiveness of anAntimicrobial Stewardship Program based on a Clinical Pathway (CP) to improve appropriateness in perioperative antibiotic prophylaxis (PAP).
Materials and Methods This pre-post quasi-experimental study was conducted in a 12 month period (six months before and six months after CP implementation),
Authors: Fidler KJ, Foster C, Lim EJ, et al.; for Collaborative HIV Paediatric Study (CHIPS) Steering Committee
Published in: Pediatr Infect Dis J. 2019;38(2):146-148
Abstract We assessed HIV antibody prevalence in children with perinatally acquired HIV in England. Eighteen percent (10/55) of those starting combination antiretroviral therapy <6 months of age were seronegative at median age 9.1 years and had lower viral load at diagnosis and combination antiretroviral therapy start and fewer viral rebounds,
Authors: Chiappini E, Bianconi M, Dalzini A, et al.
Published in: Antimicrob Resist Infect Control. 2019;8:13
Background Premature aging and related diseases have been documented in HIV-infected adults. Data are now emerging also regarding accelerated aging process in HIV-infected children.
Methods A narrative review was performed searching studies on PubMed published in English language in 2004-2017,
Authors: Bollen P, Turkova A, Mujuru H, et al. for the ODYSSEY Trial Team
Published in: 26th Conference on Retroviruses and Opportunistic Infections, March 4th – 7th, 2019– Seattle. P_830
Authors: Schröter J.
Published: Oral presentation at 26th International HIV Dynamics & Evolution, March 24th-27th, 2019, Cascais, PT