2020
Authors: Li G, Jackson C, Bielicki J, Ellis S, Hsiac Y, Sharland M
Published in: Bulletin of the World Health Organization, July 2020
Objective To investigate international consumption patterns of child-appropriate oral formulations of antibiotics by formulation type, with a focus on dispersible tablets, using data from a global sales database.
Methods Antibiotic sales data for 2015 covering 74 countries and regional country groups were obtained from the MIDAS® pharmaceutical sales database,
2020
Authors: Palma P, McManus M, Cotugno N, Rocca S, Rossi P, Luzuriaga K
Published in: Lancet HIV. 2020;7(5):e359-e365
Abstract Several assays have been developed to measure and characterise the replication-competent HIV-1 reservoir, which constitutes the barrier to cure. To date, the application of these assays to studies in children and in limited-resource settings has been minimal,
2020
Authors: Soriano-Arandes A, Frick MA, García López-Hortelano M, et al.
Published in: Pathogens 2020;9(5):E352
Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain,
2020
Authors: Dhummakupt A, Rubens JH, Andeson T, et al.
Published in: JCI Insight. 2020;5(4)
Abstract The HIV latent reservoir in resting memory CD4+ T cells precludes cure. Therapeutics to reactivate and eliminate this reservoir are in clinical trials in adults, but not yet in pediatric populations. We determined, ex vivo,
2020
Authors: Mathur S, Jackson C, Urus H, Ziarko I, Goodbun M, Hsia Y, Ellis S, Sharland M.
Published in: Bulletin of the World Health Organization, April 2020
Objective To compare dosing guidance in the paediatric formularies of high-income countries and emerging economies for 32 commonly prescribed antibiotics on the World Health Organization’s (WHO’s) 2017 Model List of Essential Medicines for Children.
2020
Authors: L. Hill, E. Jacqz-Aigrain, V. Elie, W. Zhao, M. Clements, M. Turner, I. Lutsar, P. Heath, E. Roilides, S. Walker, M. Sharland
Published in: 30th European Congress on Clinical Microbiology and Infectious Diseases (ECCMID), April 2020
2020
Authors: L. Hill, M. Clements, M. Turner, I. Lutsar, E. Jacqz-Aigrain, P. Heath, E. Roilides, S. Walker, M. Sharland
Published in: 30th European Congress on Clinical Microbiology and Infectious Diseases (ECCMID), April 2020
2020
Authors: V. Matheeussen, K. Loens, K. Jacobs, P. Horby, H. Goossens, M. Kohns Vasconcelos, M. Sharland, M. De Jong, M. P. G. Koopmans, P. Fraaij, M. Ieven
Published in: 30th European Congress on Clinical Microbiology and Infectious Diseases (ECCMID), April 2020
Background: The management of infants admitted to hospital with sepsis-like syndrome (SLS) without apparent focus remains challenging.
2020
Authors: M. Kohns Vasconcelos; on behalf of the PED-MERMAIDS Study Group
Published in: 30th European Congress on Clinical Microbiology and Infectious Diseases (ECCMID), April 2020
Background: Recently, major aetiology and outcome studies on paediatric acute respiratory tract infections (ARI) have been reported from LMICs. In contrast, studies using standardised protocols across Europe are lacking.
2020
Authors: E. Barbieri, D. Bottigliengo, P. Costenaro, A. Marzollo, M. Petris, M. Pierobon, G. Biddeci, C. Giaquinto, A. Biffi, D. Donà
Published in: 30th European Congress on Clinical Microbiology and Infectious Diseases (ECCMID), April 2020
Background: Febrile neutropenia (FN) is an acute potentially life-threatening oncological complication which should be treated promptly with antibiotics. With the spread of antibiotic resistance,
2020
Authors: P. Costenaro, A. Cantarutti, E. Barbieri, A. Scamarcia, A. Oletto, P. Sacerdoti, R. Lundin, L. Cantarutti, C. Giaquinto, D. Dona’
Published in: 30th European Congress on Clinical Microbiology and Infectious Diseases (ECCMID), April 2020
Background: Despite national and international efforts to promote appropriate antibiotic prescribing, Italian paediatric antimicrobial prescription rates are among the highest in Europe,
2020
Authors: Hill LF, Turner MA, Lutsar I, et al; NeoVanc Consortium.
Published in: Trials. 2020;21(1):329
2020
Authors: Giovanetti M, Faria NR, Lourenco J, et al.
Published in: Cell Rep. 2020;30(7):2275-2283
Abstract Zika virus (ZIKV) has caused an explosive epidemic linked to severe clinical outcomes in the Americas. As of June 2018, 4,929 ZIKV suspected infections and 46 congenital syndrome cases had been reported in Manaus,
2020
Authors: Dhummakupt A, Reubens JH, Anderson T, et al.
Published: Poster presented at 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.
Abstract The HIV latent reservoir in resting memory CD4+ T cells prevents cure. Novel therapies to reactivate and eliminate the reservoir are in clinical trials in adults, but not yet in pediatric populations.
2020
Authors: Schröter J, Anelone A, Yates A, de Boer RJ; on behalf of the EPIICAL Consortium
Published in: J Acquir Immune Defic Syndr. 2020;83(5):522-529
Background Interventions aiming for an HIV cure would benefit from rapid elimination of virus after the onset of antiretroviral therapy (ART), by keeping the latent HIV reservoir small.
2020
Authors: Dominguez-Rodriguez S, Rojo P, Lain MG, Barnabas S, Lopez-Varela E, Otwombe K, Danaviah S, Nastouli E, Serna-Pasqual M, Gianuzzi V, Giaquointo C, Kuhn L, Tagarro A on behalf of the EPIICAL Consortium
Published in: 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.
2020
Authors: Sconza R, Plotnikova Y, Plynsky A, Rozenberg V, Thorne C
Published in: 10th International Workshop on HIV & Women, 6th – 7 th March 2020, Boston, MA
2020
Authors: Crichton S, Jesson J, Aké-Assi MH, Belfrage E, Davies MA, Pinto J, Teasdale C, Van Lam N, Vreeman R, Wanless S, Williams P, Yotebieng M, Leroy V, Goodall R on behalf of the CIPHER Global Cohort Collaboration
Published in: 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.
2020
Authors: Zicari S, Doria M, Domínguez-Rodríguez S, Cotugno N, Tagarro A, Rojo P, Nastouli E, Gartner K, Klein N, Foster C, Pahwa S, De Rossi A, Giaquinto C, Rossi P, Palma P, for the EPIICAL consortium
Published in: 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.
2020
Authors: Tagarro A, Domínguez-Rodríguez S, Violari A, Cotton M, Mhampossa T, Klein N, Ramsagar N, Van Rensburg AJ, Behuhuma O, Vaz P, Oletto A, Palma P, Rossi P, Rojo P, on behalf of the EPIICAL Consortium
Published in: 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.
2020
Authors: Gärtner K, Gkouleli T, Byott M, Heaney J, Spyer MJ, DeRossi A, Persaud D, Palma P, Giaquinto C, Rojo P, Foster C, Marcelin AG, Rossi P, Nastouli E, for the EPIICAL consortium
Published in: 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.
2020
Authors: Gärtner K, Gkouleli T, Heaney J, Grant P, Dominguez-Rodriguez S, Busby E, O’Sullivan D, Spyer MJ, Foster C, Rojo P, Persaud D, DeRossi A, Huggett J, Nastouli E, for the EPIICAL consortium
Published in: 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.
2020
Authors: Waalewijn H, Mujuru HA, Amuge P, Cotton M, Bollen P, Chan M, Ali S, Variavan E, Makumbi S, Colbers A, Gibb D, Ford D, Burger D, Turkova A, and the ODYSSEY-trial team
Published in: 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.
2020
Authors: Waalewijn H, Mujuru HA, Amuge P, Cotton M, Bollen P, Chan M, Ali S, Variavan E,Makumbi S, Colbers A, Gibb D, Ford D, Burger D, Turkova A, and the ODYSSEY-trial team
Published in: Oral presentation at 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.
2020
Authors: Crichton S , Collins IJ, Turkova A, Ene L, Galli L, Marczynska M, Navarro M, Naver L, Noguera-Julian A, Plotnikova Y, Scherpbier H, Volokha A, Voronin E, Judd A; on behalf of the European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC)
Published in: 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.
Abstract
Background: The World Health Organization (WHO) recommends abacavir as the preferred/alternative backbone for 1st line regimens in children with HIV from age 28 days.
2020
Authors: Thorne C, Rasi V, Aebi-Popp K, Ene L, Floridia M, Mendoza-Palomar N, Prieto L, Ragone L, Sconza R, CGiaquinto C, Vannappagari V; for the Dolomite-EPPICC study group
Published in: Oral presentation at 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.
Abstract
BACKGROUND • In 2018,
2020
Authors: Jackson C, Bamford A, Crichton S, Goodall R,Goulder P, Klein N, Marques L, Paioni P, Riordan A, Spoulou V, Vieira VA, Collins IJ. On behalf of The European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC) study group
Published in: 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.
2020
Authors: Rinaldi S, Pallikkuth S, de Armas L, Pahwa R, Dominguez S, Cotugno N, Rojo Conejo P, Nastouli E, Gartner K, Klein N, Foster C, De Rossi A, Carlo Giaquinto C, Rossi P, Palma P, Pahwa S and EPIICAL Consortium
Published in: 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.
2020
Authors: Lain MG, Vaz P, Ismael N, Cantarutti A, Porcu G, Palma P, Cotugno N, Bila D, Rinaldi S, Pallikkuth S, Pahwa R, Taibo E, Esmeralda Karajeanes E, Giaquinto C, Pahwa S.
Published in: 27th Conference on Retroviruses and Opportunistic Infections, March 8th –11th, 2020 – Boston.
2020
Authors: Morris SE, Dziobek-Garrett L, Yates AJ and the EPIICAL consortium
Published in: BMC Bioinformatics 2020;21(1):52
Background HIV/AIDS is responsible for the deaths of one million people every year. Although mathematical modeling has provided many insights into the dynamics of HIV infection, there is still a lack of accessible tools for researchers unfamiliar with modeling techniques to apply them to their own clinical data.
2020
Authors: Ades AE, Thorne C, Soriano-Arandes A, et al.
Published in: Lancet Infect Dis. 2020 Feb 18
Abstract: Our understanding of congenital infections is based on prospective studies of women infected during pregnancy. The EU has funded three consortia to study Zika virus, each including a prospective study of pregnant women.
2020
Authors: Celia C.
Published in: Oral presentation at 3rd international Conference on Zika Virus and aedes related infections, February 13th – 16th, 2020– Washington DC, USA.
2020
Authors: Webster-Kerr K.
Published in: Oral presentation at 3rd international Conference on Zika Virus and aedes related infections, February 13th – 16th, 2020– Washington DC, USA.
2020
Authors: Lue A.
Published in: Oral presentation at 3rd international Conference on Zika Virus and aedes related infections, February 13th – 16th, 2020– Washington DC, USA.
2020
Authors: Cotugno N, Morrocchi E, Rinaldi S, et al; EPIICAL Consortium.
Published in: AIDS. 2020 Feb 3.
Objective To investigate long-term persistence of HIV-specific lymphocyte immunity in perinatally HIV-infected children treated within the first year of life.
Design Twenty perinatally HIV-infected children who received ART therapy within the first year of life (early treated) and with stable viral control (>5 years) were grouped according to their serological response to HIV.
2020
Authors: Rinaldi S, Pallikkuth S, Cameron M, et al.
Published in: J Immunol. 2020 Feb 1;204:540-549
Abstract Early initiation of antiretroviral therapy (ART) in vertically HIV-infected children limits the size of the virus reservoir, but whether the time of treatment initiation (TI) can durably impact host immune responses associated with HIV infection is still unknown.
2020
Authors: Warris A, Pana ZD, Oletto A, et al. EUROCANDY study group.
Published in: Pediatr Infect Dis J. 2020;39(2):114-120
Background Data on Candida bloodstream infections in pediatric patients in Europe are limited. We performed a retrospective multicenter European study of the epidemiology and outcome of neonatal and pediatric candidemia.
Materials and methods All first positive blood cultures from patients ≤ 18 years of age with candidemia were registered.
2020
Authors: Pereira Gusmão Maia Z, Mota Pereira F, do Carmo Said RF, et al.
Published in: Emerg Microbes Infect. 2020;9(1):53-57
Abstract Between June 2017 and August 2018, several municipalities located in Bahia state (Brazil) reported a large increase in the number of patients presenting with febrile illness similar to that of arboviral infections.
2020
Authors: Donà D, Barbieri E, Daverio M, Lundin R, Giaquinto C, Zaoutis T, Sharland M
Published in: Antimicrob Resist Infect Control.2020;9:3
Background Antibiotics are the most common medicines prescribed to children in hospitals and the community, with a high proportion of potentially inappropriate use. Antibiotic misuse increases the risk of toxicity, raises healthcare costs, and selection of resistance.
2019
Authors: S. Rinaldi, V. Dinh, S. Pallikkuth, L. De Armas, R. Pahwa, N. Cotugno, E. Nastouli, C. Foster, P. Palma, S. Pahwa
Published in: Poster presented at 9th International Workshop on HIV Persistence during Therapy; December, 2019; Miami, FL
Background: Curative strategies for HIV will need to eliminate the replication competent latent reservoir.
2019
Authors: Folgori L, Lutsar I, Standing JF, et al.
Published in: BMJ Open. 2019; 9:e032592
2019
Authors: Blazquez-Gamero D, Soriano-Ramos M, Martinez de Aragon A, et al.
Published in: Pediatr Infect Dis J. 2019;38(11):1131-1137
2019
Authors: Tedder RS, Dicks S, Ijaz S, et al.
Published in: PLoS One. 2019;14(8):e0215708
Abstract: The accurate diagnosis and seroprevalence investigations of Zika virus (ZKV) infections remain complex due to cross reactivity with other flaviviruses. Two assay formats, both using labelled Zika virus NS1 antigen as a revealing agent (a double antigen binding assay,
2019
Authors: Turner B, Ford D, Moore C, Gibb D, Turkova A, White I, and ODYSSEY trial team
Published in: Oral Presentation atInternational Society for Clinical Biostatics; July 16th 2019
2019
Authors: Giovannetti M, de Mendonca MCL, Fonseca V, et al.
Published in: J Virol. 2019;94(1). pii: e01623-19
Abstract The recent reemergence of yellow fever virus (YFV) in Brazil has raised serious concerns due to the rapid dissemination of the virus in the southeastern region. To better understand YFV genetic diversity and dynamics during the recent outbreak in southeastern Brazil,
2019
Authors: Goncalves BS, Nogueira RMR, Bispo de Filippis AM, Horta MAP
Published in: Trans R Soc Trop Med Hyg. 2019;113(11):670-677
2019
Authors: Domínguez-Rodríguez S, Tagarro A. Palma P, et al.
Published in: JAIDS 2019;82(5):483-490
2019
Authors: Schröter J.
Published in: Poster presented at 4th Workshop on Virus Dynamics, October 21st-23rd, 2019 -Paris, FR
2019
Authors: Li G, Bielicki JA, Ahmed ASMNU, et al.
Published in: Arch Dis Child.2091;0:1-6
2019
Authors:Simitsopoulou M, Kadiltzoglou P, Kyrpitzi D, Roilides E.
Published in: Int J Biol Med Res.2019;10(1):6591-6596
Abstract This study aimed to compare the effects of vancomycin, linezolid and daptomycin against planktonic cells and biofilms of 32 bloodstream isolates derived from neonates and adults of three hospitals. Staphylococcus epidermidis biofilm formation was spectrophotometrically assessed following safranin staining.